SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 8 MET A 328
PRO A 290
GLU A 294
ARG A  32
 None
 1.20A 1dtlA-1e0tA:
undetectable		 1dtlA-1e0tA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 12 ILE A   6
CYH A   8
MET A  23
LEU A  50
LEU A  33
 None
 1.28A 1fm6X-1e0tA:
0.0		 1fm6X-1e0tA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 11 LEU A 207
LEU A 178
LEU A 170
SER A 192
ALA A 190
 None
 1.08A 1ha2A-1e0tA:
0.0		 1ha2A-1e0tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		3 / 3 ALA A 406
HIS A 407
VAL A 410
 None
 0.45A 1lqtB-1e0tA:
undetectable		 1lqtB-1e0tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		3 / 3 ALA A 406
HIS A 407
VAL A 410
 None
 0.43A 1lquB-1e0tA:
undetectable		 1lquB-1e0tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 12 VAL A 416
VAL A 449
LEU A 442
LEU A 373
LEU A 470
 None
 0.97A 1mx1E-1e0tA:
2.0		 1mx1E-1e0tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 6 ILE A 268
VAL A 189
ILE A 194
ILE A 203
ASP A 238
 None
 1.25A 1uwhB-1e0tA:
undetectable		 1uwhB-1e0tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		3 / 3 GLY A 153
ASP A  82
ASN A 155
 None
 0.64A 1vq1A-1e0tA:
4.0		 1vq1A-1e0tA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 LEU A 397
PHE A 429
VAL A 449
ALA A 437
 None
 0.90A 2cizA-1e0tA:
0.0		 2cizA-1e0tA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 6 SER A 412
VAL A 410
THR A 378
PRO A 417
 None
None
SO4  A 701 (-3.4A)
None
 1.20A 2hdnJ-1e0tA:
4.3
2hdnK-1e0tA:
0.0
2hdnL-1e0tA:
4.3		 2hdnJ-1e0tA:
22.04
2hdnK-1e0tA:
6.75
2hdnL-1e0tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 6 PHE A 188
GLY A 381
GLY A 380
ASN A 402
 None
SO4  A 701 (-3.7A)
SO4  A 701 (-3.2A)
None
 0.87A 2qr2A-1e0tA:
1.5
2qr2B-1e0tA:
1.3		 2qr2A-1e0tA:
19.70
2qr2B-1e0tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 VAL A   7
VAL A  30
THR A 306
THR A   9
 None
 1.26A 3bjwG-1e0tA:
0.0		 3bjwG-1e0tA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 VAL A   7
VAL A  30
THR A 306
THR A   9
 None
 1.23A 3bjwC-1e0tA:
0.0		 3bjwC-1e0tA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 VAL A   7
VAL A  30
THR A 306
THR A   9
 None
 1.22A 3bjwD-1e0tA:
0.0		 3bjwD-1e0tA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		3 / 3 ARG A 385
VAL A 452
THR A 462
 None
 0.77A 3cyxA-1e0tA:
0.0		 3cyxA-1e0tA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		3 / 3 ASN A 159
ASP A 127
ARG A  32
 None
 0.89A 3k13A-1e0tA:
7.6		 3k13A-1e0tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 7 PHE A  35
ASP A  39
ILE A  47
VAL A 186
 None
 1.07A 3p6hA-1e0tA:
undetectable		 3p6hA-1e0tA:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		7 / 10 THR A   9
PRO A  12
ARG A  32
ASN A  34
HIS A  37
GLY A  38
GLY A 313
 None
 0.61A 3pp7B-1e0tA:
49.8		 3pp7B-1e0tA:
42.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 7 VAL A 158
PHE A  93
MET A 132
LEU A 152
 None
 1.01A 3rfmA-1e0tA:
undetectable		 3rfmA-1e0tA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		3 / 3 ARG A 342
PHE A 391
PRO A 392
 None
 0.50A 3zoaB-1e0tA:
9.4		 3zoaB-1e0tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 ILE A 264
LYS A 261
GLU A 265
PHE A 391
 None
 1.36A 4ac9C-1e0tA:
4.0		 4ac9C-1e0tA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 ILE A 264
LYS A 261
GLU A 265
PHE A 391
 None
 1.35A 4acaC-1e0tA:
2.8		 4acaC-1e0tA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 ILE A 264
LYS A 261
GLU A 265
PHE A 391
 None
 1.40A 4acbC-1e0tA:
3.6		 4acbC-1e0tA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 12 GLU A 222
ILE A 203
LEU A 178
GLY A  69
ASN A 159
 None
 1.09A 4o1eA-1e0tA:
9.3		 4o1eA-1e0tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 12 GLU A 222
ILE A 203
LEU A 178
GLY A  69
ASN A 159
 None
 1.11A 4o1eB-1e0tA:
13.5		 4o1eB-1e0tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 9 THR A  95
VAL A 163
LEU A 160
ILE A 165
PHE A  93
 None
 1.17A 4r38C-1e0tA:
undetectable		 4r38C-1e0tA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 8 THR A  95
VAL A 163
LEU A 160
ILE A 165
PHE A  93
 None
 1.17A 4r38D-1e0tA:
0.0		 4r38D-1e0tA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 4 LEU A  24
MET A  54
VAL A  53
ASN A  52
 None
 1.42A 5b8iB-1e0tA:
undetectable		 5b8iB-1e0tA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 8 ILE A 268
VAL A 189
ILE A 194
ILE A 203
ASP A 238
 None
 1.37A 5hi2A-1e0tA:
undetectable		 5hi2A-1e0tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 SER A 326
VAL A 325
GLY A  27
ALA A  26
 None
 0.94A 5k50A-1e0tA:
0.6		 5k50A-1e0tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		3 / 3 GLY A 454
THR A 461
ASN A 463
 None
 0.68A 5odiG-1e0tA:
0.2		 5odiG-1e0tA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		5 / 12 LEU A 432
GLY A 433
SER A 383
VAL A 387
ILE A 374
 None
None
SO4  A 701 (-3.2A)
None
None
 1.24A 6bxnB-1e0tA:
undetectable		 6bxnB-1e0tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1e0t PYRUVATE KINASE
(Escherichia
coli) 		4 / 5 VAL A 415
LEU A 409
HIS A 216
THR A 378
 None
None
None
SO4  A 701 (-3.4A)
 1.03A 6dyoA-1e0tA:
0.0		 6dyoA-1e0tA:
12.08