SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		4 / 7 LEU A  33
LEU A  81
SER A  82
THR A  85
 None
 1.00A 1dvxA-1e12A:
undetectable		 1dvxA-1e12A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		4 / 7 LEU A  33
LEU A  81
SER A  82
THR A  85
 None
 1.00A 1dvxB-1e12A:
undetectable		 1dvxB-1e12A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		3 / 3 THR A 198
LEU A 202
VAL A 205
 None
 0.58A 1mz9E-1e12A:
undetectable		 1mz9E-1e12A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		3 / 3 VAL A  86
VAL A 227
SER A 231
 None
 0.74A 3n8xB-1e12A:
0.0		 3n8xB-1e12A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		5 / 11 ILE A 119
ALA A  65
PHE A 245
ILE A 195
LEU A 123
 None
 1.14A 3qg2B-1e12A:
undetectable		 3qg2B-1e12A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		4 / 8 ALA A 190
GLY A 191
THR A 192
THR A 259
 None
 0.96A 3rglA-1e12A:
undetectable		 3rglA-1e12A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		5 / 12 GLY A 124
ALA A 127
PHE A 196
ALA A 184
SER A 177
 None
 1.05A 3sudA-1e12A:
undetectable		 3sudA-1e12A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		4 / 6 SER A 156
LEU A 158
HIS A  95
THR A 154
 None
 1.33A 3thrB-1e12A:
0.0		 3thrB-1e12A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		4 / 6 ALA A  40
ASN A  36
VAL A  35
ASP A 238
 None
None
None
RET  A 999 (-4.4A)
 1.02A 4g24A-1e12A:
0.8		 4g24A-1e12A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		5 / 12 ALA A  65
GLY A 124
LEU A 131
TRP A 183
ALA A 122
 None
 1.15A 4lg1C-1e12A:
undetectable		 4lg1C-1e12A:
21.62