SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		4 / 7 PHE A 162
ALA A 217
LEU A 220
VAL A  90
 None
 0.94A 1hk2A-1e1hA:
0.0		 1hk2A-1e1hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 THR A 219
HIS A 222
GLU A 223
HIS A 226
GLU B 261
 None
ZN  A 501 ( 3.3A)
None
ZN  A 501 ( 3.4A)
ZN  A 501 ( 2.2A)
 0.52A 1j36A-1e1hA:
2.4		 1j36A-1e1hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 THR A 219
HIS A 222
GLU A 223
HIS A 226
GLU B 261
 None
ZN  A 501 ( 3.3A)
None
ZN  A 501 ( 3.4A)
ZN  A 501 ( 2.2A)
 0.52A 1j36B-1e1hA:
2.3		 1j36B-1e1hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		4 / 6 TYR A  76
VAL B 378
ILE B 377
LEU B 415
 None
 1.02A 1j96A-1e1hA:
undetectable		 1j96A-1e1hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 GLY A  56
ASP A  57
ASN A  52
 None
 0.60A 1vq1A-1e1hA:
undetectable		 1vq1A-1e1hA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 LEU B 344
TYR A 232
GLY A 180
 None
 0.46A 2ocuA-1e1hB:
undetectable		 2ocuA-1e1hB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum;
Clostridium
botulinum) 		3 / 3 SER B 294
ASP B 291
ASP A 123
 None
 0.82A 3iv6A-1e1hB:
undetectable		 3iv6A-1e1hB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum;
Clostridium
botulinum) 		3 / 3 SER B 294
ASP B 291
ASP A 123
 None
 0.82A 3iv6C-1e1hB:
undetectable		 3iv6C-1e1hB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_1
(CATECHOL
O-METHYLTRANSFERASE)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum;
Clostridium
botulinum) 		5 / 12 VAL A 218
TYR B 348
ALA A 235
HIS A 226
ARG A 230
 None
None
None
ZN  A 501 ( 3.4A)
None
 1.35A 3s68A-1e1hA:
0.0		 3s68A-1e1hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 HIS A 226
HIS A 229
ILE A 225
 ZN  A 501 ( 3.4A)
None
None
 0.83A 3u52A-1e1hA:
0.0
3u52C-1e1hA:
0.0		 3u52A-1e1hA:
19.46
3u52C-1e1hA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		4 / 6 ASP B 269
GLY B 267
ASP B 351
THR B 349
 None
 1.25A 3vqrA-1e1hB:
undetectable		 3vqrA-1e1hB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		5 / 11 LEU A 102
LEU A 107
LEU A 224
ILE A 225
PHE B 353
 None
 1.07A 4odrA-1e1hA:
undetectable
4odrB-1e1hA:
undetectable		 4odrA-1e1hA:
16.55
4odrB-1e1hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 THR A 100
ASN B 390
PHE B 389
 None
 0.50A 4pd9A-1e1hA:
0.0		 4pd9A-1e1hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 ALA A  34
TRP A  42
VAL A  43
 None
 0.20A 4w9nC-1e1hA:
0.0		 4w9nC-1e1hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum;
Clostridium
botulinum) 		4 / 4 SER A 181
SER A 166
GLU B 260
ASP A 170
 None
 1.17A 4ymgA-1e1hA:
0.0		 4ymgA-1e1hA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum;
Clostridium
botulinum) 		5 / 12 VAL A 218
TYR B 348
ALA A 235
HIS A 226
ARG A 230
 None
None
None
ZN  A 501 ( 3.4A)
None
 1.32A 5fhqA-1e1hA:
0.0		 5fhqA-1e1hA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 TYR A  98
ARG A 104
THR A 108
 None
 1.02A 5z84J-1e1hA:
0.0		 5z84J-1e1hA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		4 / 4 LEU A  93
ASP A 215
PRO A 216
ARG A  96
 None
 1.43A 6fgdA-1e1hA:
undetectable		 6fgdA-1e1hA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		4 / 7 ARG B 263
TYR B 285
LEU B 283
TYR B 341
 None
 1.24A 6g2pA-1e1hB:
undetectable		 6g2pA-1e1hB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN
(Clostridium
botulinum) 		4 / 5 GLY A 180
LEU A 174
SER A 166
GLN A 183
 None
 0.98A 6ji6A-1e1hA:
0.0		 6ji6A-1e1hA:
21.14