SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 7 LEU A 324
ALA A 148
VAL A 192
TYR A 130
 None
 0.58A 1epbA-1e1kA:
undetectable		 1epbA-1e1kA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 8 LEU A 324
ALA A 148
VAL A 192
TYR A 130
 None
 0.62A 1epbB-1e1kA:
0.0		 1epbB-1e1kA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 6 LEU A 164
LEU A 216
HIS A  55
LEU A 139
 None
None
FAD  A 801 ( 4.9A)
None
 0.67A 1errA-1e1kA:
undetectable		 1errA-1e1kA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 LEU A 143
ALA A 179
ALA A 183
VAL A 189
TYR A 130
 None
 1.16A 1kt4A-1e1kA:
0.0		 1kt4A-1e1kA:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1869_0
(FPRA)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 4 ASP A  54
HIS A  55
ARG A 162
GLU A 212
 None
FAD  A 801 ( 4.9A)
None
None
 0.39A 1lqtA-1e1kA:
50.3		 1lqtA-1e1kA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1871_0
(FPRA)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 7 PHE A  19
PRO A  43
ALA A  69
PHE A  76
TRP A 427
 None
 0.46A 1lqtA-1e1kA:
50.3		 1lqtA-1e1kA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_A_ACTA1426_0
(FPRA)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 4 ASP A  54
HIS A  55
ARG A 162
GLU A 212
 None
FAD  A 801 ( 4.9A)
None
None
 0.47A 1lquA-1e1kA:
50.1		 1lquA-1e1kA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_A_ACTA1428_0
(FPRA)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 7 PHE A  19
PRO A  43
ALA A  69
PHE A  76
TRP A 427
 None
 0.48A 1lquA-1e1kA:
50.1		 1lquA-1e1kA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 9 GLU A 433
ARG A 437
LEU A 448
GLU A 453
HIS A 460
 None
 1.46A 1mjlA-1e1kA:
undetectable
1mjlB-1e1kA:
undetectable		 1mjlA-1e1kA:
11.83
1mjlB-1e1kA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 11 HIS A 460
GLU A 433
ARG A 437
LEU A 448
GLU A 453
 None
 1.45A 1mjqA-1e1kA:
undetectable
1mjqB-1e1kA:
undetectable		 1mjqA-1e1kA:
11.83
1mjqB-1e1kA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 10 HIS A 460
GLU A 433
ARG A 437
LEU A 448
GLU A 453
 None
 1.44A 1mjqG-1e1kA:
undetectable
1mjqH-1e1kA:
undetectable		 1mjqG-1e1kA:
11.83
1mjqH-1e1kA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 8 VAL A 127
TYR A 130
ASP A  54
LEU A  46
 FAD  A 801 ( 4.9A)
None
None
FAD  A 801 (-3.5A)
 1.18A 1pk2A-1e1kA:
undetectable		 1pk2A-1e1kA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 LEU A 210
ILE A 194
SER A 328
LEU A 223
LEU A 245
 None
None
NAP  A 802 (-4.1A)
None
None
 0.97A 1xdkB-1e1kA:
undetectable		 1xdkB-1e1kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 LEU A 210
ILE A 194
SER A 328
LEU A 223
LEU A 245
 None
None
NAP  A 802 (-4.1A)
None
None
 0.97A 1xdkF-1e1kA:
undetectable		 1xdkF-1e1kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 9 THR A  21
GLY A  18
TYR A  37
LEU A  91
LEU A 390
 None
 1.24A 2npnA-1e1kA:
undetectable		 2npnA-1e1kA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		3 / 3 VAL A 120
GLU A 116
GLU A 115
 None
 0.80A 2nv4A-1e1kA:
0.0		 2nv4A-1e1kA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 7 GLY A 330
ASP A 106
TYR A 331
ARG A 334
 NAP  A 802 ( 3.8A)
None
NAP  A 802 (-4.8A)
None
 1.04A 3aruA-1e1kA:
undetectable		 3aruA-1e1kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		3 / 3 TYR A 130
ASP A 175
HIS A  55
 None
None
FAD  A 801 ( 4.9A)
 0.88A 3e23A-1e1kA:
undetectable		 3e23A-1e1kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 LEU A  46
GLY A 128
LEU A 449
PRO A 134
ASP A 175
 FAD  A 801 (-3.5A)
None
None
None
None
 1.13A 3i5uA-1e1kA:
3.8		 3i5uA-1e1kA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 LEU A  46
GLY A 128
LEU A 449
PRO A 134
ASP A 175
 FAD  A 801 (-3.5A)
None
None
None
None
 1.12A 3i5uB-1e1kA:
2.1		 3i5uB-1e1kA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.09A 4jkuB-1e1kA:
4.6		 4jkuB-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.09A 4k8tB-1e1kA:
4.5		 4k8tB-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.09A 4k93B-1e1kA:
4.6		 4k93B-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.09A 4k9cB-1e1kA:
4.6		 4k9cB-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.10A 4k9iA-1e1kA:
4.2		 4k9iA-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.10A 4kadB-1e1kA:
5.0		 4kadB-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.10A 4lbxA-1e1kA:
4.6		 4lbxA-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.10A 4lbxB-1e1kA:
4.6		 4lbxB-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 ASP A 382
ASN A 351
SER A 383
THR A  21
LEU A  25
 None
 1.10A 4lc4B-1e1kA:
4.6		 4lc4B-1e1kA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 GLY A  45
GLY A  15
PHE A  44
PHE A  65
GLN A  23
 FAD  A 801 (-3.1A)
FAD  A 801 (-3.5A)
None
None
None
 1.22A 4ubeA-1e1kA:
5.3		 4ubeA-1e1kA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 6 ASP A 319
THR A 314
PRO A 313
THR A 300
 None
 1.14A 4yoaA-1e1kA:
0.0		 4yoaA-1e1kA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 7 ASN A 351
LYS A 369
TYR A 102
PHE A  19
 None
 1.25A 4yv5A-1e1kA:
1.6		 4yv5A-1e1kA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 7 THR A 379
TYR A  20
PRO A  16
SER A 383
 FAD  A 801 (-3.7A)
None
FAD  A 801 (-3.9A)
None
 1.37A 5b6iA-1e1kA:
2.3		 5b6iA-1e1kA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 7 ILE A 336
LEU A 133
PHE A  49
ASP A 106
 FAD  A 801 ( 4.9A)
None
None
None
 0.77A 5hieB-1e1kA:
undetectable		 5hieB-1e1kA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		5 / 12 VAL A 156
ASP A 159
SER A 328
GLN A  40
GLY A 128
 NAP  A 802 (-3.7A)
NAP  A 802 ( 4.3A)
NAP  A 802 (-4.1A)
None
None
 1.18A 5syeB-1e1kA:
2.7		 5syeB-1e1kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		6 / 11 LEU A 394
ASP A 393
ILE A 389
GLY A 361
LEU A 391
THR A 386
 None
 1.23A 5twjD-1e1kA:
undetectable		 5twjD-1e1kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 1e1k ADRENODOXIN
REDUCTASE
(Bos
taurus) 		4 / 8 HIS A 107
GLY A 330
LEU A 151
GLY A 152
 None
NAP  A 802 ( 3.8A)
None
NAP  A 802 (-3.6A)
 0.81A 6mdqA-1e1kA:
undetectable		 6mdqA-1e1kA:
10.12