SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
None
None
GOL  A 609 ( 3.9A)
 0.70A 1d4sB-1e1tA:
0.0		 1d4sB-1e1tA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 LEU A 326
ALA A 379
ASP A 376
GLY A 419
ILE A 384
 None
None
None
None
GOL  A 609 ( 3.9A)
 1.12A 1d4yA-1e1tA:
undetectable		 1d4yA-1e1tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
None
None
GOL  A 609 ( 3.9A)
 0.65A 1d4yB-1e1tA:
0.0		 1d4yB-1e1tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 8 LEU A 353
ILE A 374
GLU A 377
VAL A 378
ILE A 332
 None
 1.17A 1linA-1e1tA:
undetectable		 1linA-1e1tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		3 / 3 ASP A 431
GLU A 441
TYR A 456
 None
 0.70A 1wsvA-1e1tA:
0.0		 1wsvA-1e1tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 11 HIS A 489
ASN A 487
ILE A 422
LEU A 305
ILE A 189
 GOL  A 605 (-4.0A)
None
None
None
None
 1.23A 2h42A-1e1tA:
0.0		 2h42A-1e1tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
None
None
GOL  A 609 ( 3.9A)
 0.76A 2o4nB-1e1tA:
undetectable		 2o4nB-1e1tA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 7 GLY A 418
GLY A 477
PHE A 297
PHE A 319
 GOL  A 605 (-4.0A)
LAD  A 601 (-3.4A)
None
None
 0.88A 2qwxA-1e1tA:
undetectable
2qwxB-1e1tA:
undetectable		 2qwxA-1e1tA:
18.50
2qwxB-1e1tA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 12 ILE A 193
LEU A 296
ILE A 257
PHE A 415
PRO A 239
 None
None
GOL  A 606 (-4.7A)
None
None
 1.15A 2ygpA-1e1tA:
0.0		 2ygpA-1e1tA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 LEU A 292
SER A 295
PHE A 196
ALA A 199
 None
 1.00A 3ax9A-1e1tA:
0.0		 3ax9A-1e1tA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 LEU A 292
SER A 295
PHE A 196
ALA A 199
 None
 0.94A 3ax9B-1e1tA:
0.0		 3ax9B-1e1tA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 6 ASP A 493
ARG A 165
ILE A 495
ARG A 186
 None
 1.50A 3ckzA-1e1tA:
undetectable		 3ckzA-1e1tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 SER A 488
THR A 486
ASN A 487
TYR A 312
 None
None
None
GOL  A 605 (-4.4A)
 0.87A 3dmtC-1e1tA:
undetectable		 3dmtC-1e1tA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 CYH A 139
ILE A 137
VAL A  69
GLY A 122
LEU A 103
 None
 1.26A 3em0A-1e1tA:
0.0		 3em0A-1e1tA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		6 / 12 LEU A 326
ALA A 379
ASP A 376
GLY A 419
ILE A 384
ILE A 389
 None
None
None
None
GOL  A 609 ( 3.9A)
None
 1.39A 3jw2B-1e1tA:
0.0		 3jw2B-1e1tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 LEU A 326
ALA A 379
ASP A 376
GLY A 419
ILE A 384
 None
None
None
None
GOL  A 609 ( 3.9A)
 1.13A 3nu9B-1e1tA:
undetectable		 3nu9B-1e1tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 7 ARG A  76
SER A  83
VAL A  85
VAL A  98
 None
 0.86A 3o14A-1e1tA:
0.0		 3o14A-1e1tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 7 ARG A 186
GLY A 423
ILE A 422
THR A 275
 None
LAD  A 601 ( 3.7A)
None
GOL  A 606 ( 4.4A)
 0.82A 3spkB-1e1tA:
0.0		 3spkB-1e1tA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 7 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
None
None
GOL  A 609 ( 3.9A)
 0.74A 3spkB-1e1tA:
0.0		 3spkB-1e1tA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 11 PHE A 297
PHE A 415
ILE A 476
GLY A 477
LEU A 484
 None
None
None
LAD  A 601 (-3.4A)
None
 1.15A 3t3rA-1e1tA:
0.0		 3t3rA-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 11 PHE A 297
PHE A 485
PHE A 415
ILE A 476
GLY A 477
 None
None
None
None
LAD  A 601 (-3.4A)
 1.11A 3t3rA-1e1tA:
0.0		 3t3rA-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 PHE A 297
PHE A 485
PHE A 415
ILE A 476
GLY A 477
 None
None
None
None
LAD  A 601 (-3.4A)
 1.17A 3t3rD-1e1tA:
0.0		 3t3rD-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 6 THR A  86
ARG A  41
ILE A 121
LEU A 117
 None
 1.13A 4ac9C-1e1tA:
undetectable		 4ac9C-1e1tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 6 THR A  86
ARG A  41
ILE A 121
LEU A 117
 None
 1.14A 4acaC-1e1tA:
undetectable		 4acaC-1e1tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 ARG A 262
PHE A 274
GLY A 423
ARG A 480
 LAD  A 601 ( 2.6A)
LAD  A 601 (-3.4A)
LAD  A 601 ( 3.7A)
POP  A 602 ( 2.4A)
 0.43A 4k87A-1e1tA:
10.8		 4k87A-1e1tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		3 / 3 LYS A 309
ASN A 487
ASP A 318
 None
 0.75A 4o1eA-1e1tA:
undetectable		 4o1eA-1e1tA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 LEU A 152
LEU A 117
LEU A 142
LEU A  96
VAL A  98
 None
 1.16A 4po0A-1e1tA:
undetectable		 4po0A-1e1tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		3 / 3 LEU A 429
LEU A 464
ARG A 236
 None
 0.58A 5hnzB-1e1tA:
undetectable		 5hnzB-1e1tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 12 PHE A 323
LEU A 474
ILE A 422
PHE A 297
LEU A 296
 None
 1.23A 5uanB-1e1tA:
undetectable		 5uanB-1e1tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 12 PHE A 323
LEU A 474
ILE A 476
ILE A 422
LEU A 296
 None
 1.27A 5uanB-1e1tA:
undetectable		 5uanB-1e1tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
MG  A 603 (-2.7A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.40A 6bniA-1e1tA:
46.9		 6bniA-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.42A 6bniA-1e1tA:
46.9		 6bniA-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
MG  A 603 (-2.7A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.37A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-4.0A)
POP  A 602 (-4.0A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
POP  A 602 ( 2.4A)
None
 0.41A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 10 ASN A 260
ARG A 262
PHE A 274
GLY A 477
ILE A 495
 None
LAD  A 601 ( 2.6A)
LAD  A 601 (-3.4A)
LAD  A 601 (-3.4A)
None
 1.23A 6bniB-1e1tA:
46.6		 6bniB-1e1tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		4 / 8 ILE A 491
THR A 490
THR A 486
SER A 179
 None
 1.10A 6c06C-1e1tA:
0.0		 6c06C-1e1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		5 / 12 LEU A 326
ALA A 379
ASP A 376
GLY A 419
ILE A 384
 None
None
None
None
GOL  A 609 ( 3.9A)
 1.10A 6difA-1e1tA:
undetectable		 6difA-1e1tA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE
(Escherichia
coli) 		3 / 3 VAL A 361
GLU A 362
ILE A 370
 None
 0.52A 6f7lB-1e1tA:
undetectable		 6f7lB-1e1tA:
22.33