SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 HIS A 259
LEU A  60
ALA A  63
GLU A  39
ASP A  42
 None
 1.47A 1a4lB-1e2tA:
undetectable		 1a4lB-1e2tA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 7 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.02A 2eimP-1e2tA:
undetectable
2eimW-1e2tA:
0.0		 2eimP-1e2tA:
23.15
2eimW-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 ILE A  36
GLU A  39
HIS A 259
GLY A  66
GLU A  71
 None
 1.42A 2fn1A-1e2tA:
undetectable		 2fn1A-1e2tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 11 ILE A  36
GLU A  39
HIS A 259
GLY A  66
GLU A  71
 None
 1.43A 2fn1B-1e2tA:
undetectable		 2fn1B-1e2tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 LEU A  44
MET A 270
LEU A 266
GLU A  39
 None
 1.26A 2kuhA-1e2tA:
0.0		 2kuhA-1e2tA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 ARG A  65
ASP A  42
ILE A  49
GLU A  39
 None
 1.36A 2xrzA-1e2tA:
undetectable
2xrzB-1e2tA:
undetectable		 2xrzA-1e2tA:
20.33
2xrzB-1e2tA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 LEU A 246
GLY A 251
LEU A 242
SER A 241
 None
 0.92A 3aiaA-1e2tA:
undetectable		 3aiaA-1e2tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 7 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.04A 3asnP-1e2tA:
undetectable
3asnW-1e2tA:
0.0		 3asnP-1e2tA:
23.15
3asnW-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 7 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.05A 3asoP-1e2tA:
undetectable
3asoW-1e2tA:
undetectable		 3asoP-1e2tA:
23.15
3asoW-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 GLU A  48
GLU A  71
ASN A 188
 None
 0.81A 3lp9B-1e2tA:
2.0
3lp9D-1e2tA:
2.0		 3lp9B-1e2tA:
19.31
3lp9D-1e2tA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		6 / 6 PHE A  38
TYR A  68
CYH A  69
VAL A  94
THR A 106
PHE A 199
 None
 0.63A 3ltwA-1e2tA:
37.3		 3ltwA-1e2tA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 SER A 156
GLY A 155
GLN A 153
 None
 0.52A 3v4tH-1e2tA:
0.0		 3v4tH-1e2tA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.05A 3wg7P-1e2tA:
undetectable
3wg7W-1e2tA:
0.0		 3wg7P-1e2tA:
23.15
3wg7W-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 PHE A 174
TYR A 172
PHE A 125
LEU A  96
LEU A 151
 None
 1.17A 4j03A-1e2tA:
undetectable		 4j03A-1e2tA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 ASP A 122
LEU A 110
ARG A  81
THR A 129
 None
 1.42A 4p3qA-1e2tA:
undetectable		 4p3qA-1e2tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 7 ASP A 122
THR A 129
VAL A  94
TYR A 172
 None
 1.02A 5ov9A-1e2tA:
undetectable		 5ov9A-1e2tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.00A 5x19C-1e2tA:
undetectable
5x19J-1e2tA:
0.0		 5x19C-1e2tA:
23.15
5x19J-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 6 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.02A 5x19P-1e2tA:
undetectable		 5x19P-1e2tA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 5 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.03A 5x1bP-1e2tA:
undetectable		 5x1bP-1e2tA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		4 / 7 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.01A 5x1fP-1e2tA:
undetectable
5x1fW-1e2tA:
0.0		 5x1fP-1e2tA:
23.15
5x1fW-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 PHE A  38
ILE A  49
VAL A  43
PHE A 199
HIS A 107
 None
 1.16A 6ap6A-1e2tA:
undetectable		 6ap6A-1e2tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 PHE A  38
VAL A 123
ILE A  49
VAL A  43
HIS A 107
 None
 1.30A 6ap6A-1e2tA:
undetectable		 6ap6A-1e2tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 PHE A  38
ILE A  49
VAL A  43
PHE A 199
HIS A 107
 None
 1.17A 6ap6B-1e2tA:
undetectable		 6ap6B-1e2tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		5 / 12 PHE A  38
VAL A 123
ILE A  49
VAL A  43
HIS A 107
 None
 1.30A 6ap6B-1e2tA:
undetectable		 6ap6B-1e2tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE
(Salmonella
enterica) 		3 / 3 HIS A 208
ASN A  33
LEU A  30
 None
 0.89A 6f7lB-1e2tA:
undetectable		 6f7lB-1e2tA:
20.93