SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 1e2y TRYPAREDOXIN
PEROXIDASE
(Crithidia
fasciculata) 		5 / 11 TYR A  34
GLY A 137
LEU A  41
TYR A 116
GLU A  14
 None
 1.37A 1jkhA-1e2yA:
undetectable
1jkhB-1e2yA:
0.0		 1jkhA-1e2yA:
15.81
1jkhB-1e2yA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1e2y TRYPAREDOXIN
PEROXIDASE
(Crithidia
fasciculata) 		5 / 9 VAL A  40
VAL A 153
ASP A  62
ILE A 157
VAL A 156
 None
 1.32A 2l8mA-1e2yA:
0.0		 2l8mA-1e2yA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1e2y TRYPAREDOXIN
PEROXIDASE
(Crithidia
fasciculata) 		4 / 6 ALA A  12
ILE A 133
LEU A  31
ALA A 115
 None
 0.83A 3r9sC-1e2yA:
undetectable		 3r9sC-1e2yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1e2y TRYPAREDOXIN
PEROXIDASE
(Crithidia
fasciculata) 		4 / 6 PHE A 131
GLY A 117
TYR A 116
ALA A 115
 None
 1.30A 4yshB-1e2yA:
0.6		 4yshB-1e2yA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e2y TRYPAREDOXIN
PEROXIDASE
(Crithidia
fasciculata) 		4 / 8 LEU A  41
ILE A 142
PHE A  43
GLY A 117
 None
 0.83A 5eseA-1e2yA:
undetectable		 5eseA-1e2yA:
15.58