SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A  83
VAL A  89
ALA A  84
LEU A  75
TYR A 102
 None
 1.03A 2japA-1e2zA:
undetectable		 2japA-1e2zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A  83
VAL A  89
ALA A  84
LEU A  75
TYR A 102
 None
 1.00A 2japB-1e2zA:
undetectable		 2japB-1e2zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A  83
VAL A  89
ALA A  84
LEU A  75
TYR A 102
 None
 1.03A 2japC-1e2zA:
undetectable		 2japC-1e2zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A  83
VAL A  89
ALA A  84
LEU A  75
TYR A 102
 None
 1.01A 2japD-1e2zA:
undetectable		 2japD-1e2zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 9 LEU A  83
ILE A 244
ILE A  76
VAL A 128
ILE A 130
 None
 1.10A 2r5qA-1e2zA:
undetectable		 2r5qA-1e2zA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 9 LEU A  83
ILE A 244
ILE A  76
VAL A 128
ILE A 130
 None
 1.10A 2r5qC-1e2zA:
undetectable		 2r5qC-1e2zA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		6 / 12 LEU A 214
LEU A 185
GLU A 193
ALA A 181
ALA A 184
THR A 183
 None
 1.40A 3mdvB-1e2zA:
undetectable		 3mdvB-1e2zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 236
GLY A 155
ASN A 168
VAL A  71
ALA A  30
 None
HEC  A 900 (-3.5A)
None
HEC  A 900 (-4.7A)
None
 1.12A 3p2kB-1e2zA:
undetectable		 3p2kB-1e2zA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A  19
CYH A  21
GLY A 238
ILE A  33
ALA A 240
 None
HEC  A 900 (-1.8A)
None
None
None
 1.11A 4kicB-1e2zA:
undetectable		 4kicB-1e2zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 100
TYR A 102
ILE A  49
GLY A  72
 None
None
None
HEC  A 900 (-3.9A)
 1.02A 4l39A-1e2zA:
undetectable		 4l39A-1e2zA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A 113
ALA A  47
VAL A  89
ILE A  93
 None
 0.90A 4xe3A-1e2zA:
0.0		 4xe3A-1e2zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A 113
ALA A  47
VAL A  89
ILE A  93
 None
 0.94A 4xe3B-1e2zA:
0.0		 4xe3B-1e2zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		4 / 5 PRO A 129
VAL A  97
GLY A 152
VAL A 115
 None
 1.07A 6ak3B-1e2zA:
0.0		 6ak3B-1e2zA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		3 / 3 TYR A 149
PRO A  78
LEU A  77
 None
 0.88A 6beoA-1e2zA:
undetectable		 6beoA-1e2zA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1e2z CYTOCHROME F
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A 246
TYR A 146
ILE A  49
GLY A  80
 None
 1.07A 6hd6A-1e2zA:
undetectable		 6hd6A-1e2zA:
15.85