SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 7 ARG A 222
LEU A 204
GLY A 203
PHE A 202
 None
None
NAI  A 377 (-3.4A)
None
 0.89A 1rtsB-1e3eA:
undetectable		 1rtsB-1e3eA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 7 VAL A 201
CYH A  46
CYH A 215
CYH A 206
 None
ZN  A 378 (-2.5A)
None
None
 1.16A 1t46A-1e3eA:
undetectable		 1t46A-1e3eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		3 / 3 LYS A  98
ASP A 336
ASP A 328
 None
 0.94A 2br4D-1e3eA:
5.3		 2br4D-1e3eA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		5 / 12 PHE A  93
ALA A 273
ALA A 298
GLY A 208
GLY A 203
 None
NAI  A 377 ( 3.9A)
None
None
NAI  A 377 (-3.4A)
 1.15A 2igtA-1e3eA:
5.4		 2igtA-1e3eA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		5 / 12 PHE A  93
ALA A 273
ALA A 298
GLY A 208
GLY A 203
 None
NAI  A 377 ( 3.9A)
None
None
NAI  A 377 (-3.4A)
 1.15A 2igtB-1e3eA:
7.3		 2igtB-1e3eA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 5 ASN A 317
ALA A 282
GLY A 291
THR A 194
 None
 0.80A 3dl9A-1e3eA:
0.0		 3dl9A-1e3eA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		5 / 9 VAL A 201
ILE A 212
GLY A 214
ILE A 188
THR A 294
 None
 1.23A 3el4B-1e3eA:
undetectable		 3el4B-1e3eA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		5 / 12 GLY A 177
VAL A 156
GLY A  71
THR A 154
VAL A 147
 None
 0.91A 3el5B-1e3eA:
undetectable		 3el5B-1e3eA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 6 ILE A  90
PRO A  91
PHE A  92
PHE A 321
 None
 0.94A 4fgkA-1e3eA:
4.0		 4fgkA-1e3eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 8 GLY A   4
GLY A   1
GLU A  74
VAL A  28
 None
 0.92A 4fgzA-1e3eA:
5.5		 4fgzA-1e3eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 7 ASN A 332
PRO A 331
TRP A 324
PHE A 180
 None
 1.46A 4v32C-1e3eA:
0.0		 4v32C-1e3eA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 5 ALA A 241
ALA A 225
ILE A 212
LEU A 209
 None
 0.60A 5jncD-1e3eA:
0.0		 5jncD-1e3eA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 6 GLY A 177
GLU A  68
PHE A  92
ILE A  38
 None
 0.92A 5kmfA-1e3eA:
undetectable
5kmfC-1e3eA:
0.0		 5kmfA-1e3eA:
20.83
5kmfC-1e3eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		5 / 9 LEU A  21
ALA A  12
PHE A 150
VAL A  45
ILE A 361
 None
 1.21A 5om2A-1e3eA:
0.0
5om2B-1e3eA:
undetectable		 5om2A-1e3eA:
12.63
5om2B-1e3eA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 8 ARG A 314
VAL A 283
GLY A 289
LEU A 288
 None
 0.79A 5sxqA-1e3eA:
0.0		 5sxqA-1e3eA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 8 ARG A 314
VAL A 283
GLY A 289
LEU A 288
 None
 0.74A 5sxtA-1e3eA:
0.0		 5sxtA-1e3eA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 8 ARG A 314
VAL A 283
GLY A 289
LEU A 288
 None
 0.73A 5sxtB-1e3eA:
0.0		 5sxtB-1e3eA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		4 / 8 ARG A 314
VAL A 283
GLY A 289
LEU A 288
 None
 0.78A 5syjB-1e3eA:
0.0		 5syjB-1e3eA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		5 / 12 GLY A 203
ASP A 227
ILE A 228
ASN A 229
LYS A 232
 NAI  A 377 (-3.4A)
NAI  A 377 (-3.0A)
NAI  A 377 ( 4.2A)
None
NAI  A 377 ( 4.5A)
 0.67A 5wy0A-1e3eA:
undetectable		 5wy0A-1e3eA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e3e ALCOHOL
DEHYDROGENASE, CLASS
II
(Mus
musculus) 		5 / 12 GLY A 265
GLY A 318
THR A 190
LEU A 270
PHE A 202
 None
 1.23A 6e8qA-1e3eA:
undetectable		 6e8qA-1e3eA:
11.17