SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 ILE A 198
GLY A 158
VAL A 186
ALA A 141
SER A 142
 None
 1.33A 1nbhA-1e3hA:
undetectable		 1nbhA-1e3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 ILE A 198
GLY A 158
VAL A 186
ALA A 141
SER A 142
 None
 1.32A 1nbhC-1e3hA:
0.2		 1nbhC-1e3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 ILE A 198
GLY A 158
VAL A 186
ALA A 141
SER A 142
 None
 1.32A 1nbhD-1e3hA:
undetectable		 1nbhD-1e3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 GLY A 158
GLY A 157
LEU A 101
PRO A 105
ASP A 134
 None
None
None
None
SO4  A 903 (-3.8A)
 0.99A 1qzzA-1e3hA:
undetectable		 1qzzA-1e3hA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 268
LEU A 271
ALA A 274
VAL A 298
LEU A 328
 None
 1.05A 1s9pA-1e3hA:
undetectable		 1s9pA-1e3hA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 268
LEU A 271
ALA A 274
VAL A 298
LEU A 328
 None
 1.07A 1s9pD-1e3hA:
undetectable		 1s9pD-1e3hA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 GLY A 158
GLY A 157
LEU A 101
PRO A 105
ASP A 134
 None
None
None
None
SO4  A 903 (-3.8A)
 1.00A 1xdsB-1e3hA:
undetectable		 1xdsB-1e3hA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 229
LEU A 535
PHE A 521
ILE A 542
LEU A 492
 None
 1.07A 2oipA-1e3hA:
undetectable		 2oipA-1e3hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 229
LEU A 535
PHE A 521
ILE A 542
LEU A 492
 None
 1.09A 2oipD-1e3hA:
undetectable		 2oipD-1e3hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 7 ILE A 334
ARG A 330
ASP A 518
LEU A 492
 None
 1.03A 2qqcB-1e3hA:
0.0
2qqcC-1e3hA:
undetectable		 2qqcB-1e3hA:
12.55
2qqcC-1e3hA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 7 ASP A 518
LEU A 492
ILE A 334
ARG A 330
 None
 1.07A 2qqcA-1e3hA:
undetectable
2qqcF-1e3hA:
0.0		 2qqcA-1e3hA:
6.35
2qqcF-1e3hA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 7 ASP A 518
LEU A 492
ILE A 334
ARG A 330
 None
 1.05A 2qqcI-1e3hA:
undetectable
2qqcL-1e3hA:
0.0		 2qqcI-1e3hA:
6.35
2qqcL-1e3hA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 384
ARG A 397
GLN A 388
ARG A 442
 None
SO4  A 902 (-3.7A)
None
SO4  A 902 (-3.9A)
 1.27A 2vxaA-1e3hA:
0.0
2vxaC-1e3hA:
0.0
2vxaE-1e3hA:
0.0		 2vxaA-1e3hA:
6.76
2vxaC-1e3hA:
6.76
2vxaE-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 397
GLN A 388
ARG A 384
ARG A 442
 SO4  A 902 (-3.7A)
None
None
SO4  A 902 (-3.9A)
 1.28A 2vxaA-1e3hA:
0.0
2vxaB-1e3hA:
0.0
2vxaK-1e3hA:
0.0		 2vxaA-1e3hA:
6.76
2vxaB-1e3hA:
6.76
2vxaK-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 397
GLN A 388
ARG A 384
ARG A 442
 SO4  A 902 (-3.7A)
None
None
SO4  A 902 (-3.9A)
 1.28A 2vxaB-1e3hA:
0.0
2vxaC-1e3hA:
0.0
2vxaG-1e3hA:
0.0		 2vxaB-1e3hA:
6.76
2vxaC-1e3hA:
6.76
2vxaG-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 384
ARG A 397
GLN A 388
ARG A 442
 None
SO4  A 902 (-3.7A)
None
SO4  A 902 (-3.9A)
 1.26A 2vxaD-1e3hA:
0.0
2vxaF-1e3hA:
0.0
2vxaI-1e3hA:
0.0		 2vxaD-1e3hA:
6.76
2vxaF-1e3hA:
6.76
2vxaI-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 397
GLN A 388
ARG A 384
ARG A 442
 SO4  A 902 (-3.7A)
None
None
SO4  A 902 (-3.9A)
 1.28A 2vxaD-1e3hA:
0.0
2vxaE-1e3hA:
0.0
2vxaL-1e3hA:
0.0		 2vxaD-1e3hA:
6.76
2vxaE-1e3hA:
6.76
2vxaL-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 442
ARG A 397
GLN A 388
ARG A 384
 SO4  A 902 (-3.9A)
SO4  A 902 (-3.7A)
None
None
 1.27A 2vxaB-1e3hA:
0.0
2vxaG-1e3hA:
0.0
2vxaH-1e3hA:
0.0		 2vxaB-1e3hA:
6.76
2vxaG-1e3hA:
6.76
2vxaH-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 397
GLN A 388
ARG A 384
ARG A 442
 SO4  A 902 (-3.7A)
None
None
SO4  A 902 (-3.9A)
 1.31A 2vxaH-1e3hA:
0.0
2vxaI-1e3hA:
0.0
2vxaJ-1e3hA:
0.0		 2vxaH-1e3hA:
6.76
2vxaI-1e3hA:
6.76
2vxaJ-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 442
ARG A 384
ARG A 397
GLN A 388
 SO4  A 902 (-3.9A)
None
SO4  A 902 (-3.7A)
None
 1.27A 2vxaD-1e3hA:
0.0
2vxaJ-1e3hA:
0.0
2vxaL-1e3hA:
0.0		 2vxaD-1e3hA:
6.76
2vxaJ-1e3hA:
6.76
2vxaL-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 442
ARG A 397
GLN A 388
ARG A 384
 SO4  A 902 (-3.9A)
SO4  A 902 (-3.7A)
None
None
 1.30A 2vxaH-1e3hA:
0.0
2vxaJ-1e3hA:
0.0
2vxaK-1e3hA:
0.0		 2vxaH-1e3hA:
6.76
2vxaJ-1e3hA:
6.76
2vxaK-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 8 ARG A 442
ARG A 397
GLN A 388
ARG A 384
 SO4  A 902 (-3.9A)
SO4  A 902 (-3.7A)
None
None
 1.29A 2vxaA-1e3hA:
0.0
2vxaK-1e3hA:
0.0
2vxaL-1e3hA:
0.0		 2vxaA-1e3hA:
6.76
2vxaK-1e3hA:
6.76
2vxaL-1e3hA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 ILE A 569
GLY A 363
SER A 364
LEU A 475
ASP A 573
 None
 0.93A 2yvlC-1e3hA:
undetectable		 2yvlC-1e3hA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 229
LEU A 535
PHE A 521
ILE A 542
LEU A 492
 None
 1.13A 3hj3A-1e3hA:
undetectable		 3hj3A-1e3hA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 229
LEU A 535
PHE A 521
ILE A 542
LEU A 492
 None
 1.08A 3hj3B-1e3hA:
undetectable		 3hj3B-1e3hA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 7 SER A 364
VAL A 361
VAL A 377
LEU A 375
 None
 0.82A 3o14A-1e3hA:
0.1		 3o14A-1e3hA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		3 / 3 LEU A 474
ARG A 433
ASN A 403
 None
 0.62A 3qxvD-1e3hA:
undetectable		 3qxvD-1e3hA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 GLY A 376
ARG A 433
GLY A 465
SER A 466
ALA A 434
 None
 1.17A 3sueB-1e3hA:
undetectable		 3sueB-1e3hA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 7 ALA A 489
ILE A 488
ARG A 349
GLY A 465
 None
 0.86A 3v4tH-1e3hA:
undetectable		 3v4tH-1e3hA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 106
SER A 153
ILE A 102
ALA A 122
LEU A 246
 None
 1.43A 3vw1B-1e3hA:
0.0		 3vw1B-1e3hA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 PHE A 110
PRO A 151
PRO A 258
ALA A  53
SER A  54
 None
None
None
None
SO4  A 901 (-4.1A)
 1.38A 4a84A-1e3hA:
1.2		 4a84A-1e3hA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		3 / 3 ARG A 349
ASP A 520
GLN A 534
 None
 0.80A 4azsA-1e3hA:
undetectable		 4azsA-1e3hA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		3 / 3 ASP A  42
ARG A  20
ASP A 130
 None
 0.74A 4fp9D-1e3hA:
undetectable		 4fp9D-1e3hA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		3 / 3 ASP A  42
ARG A  20
ASP A 130
 None
 0.88A 4fzvA-1e3hA:
undetectable		 4fzvA-1e3hA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 6 LEU A 392
LEU A 132
THR A  98
VAL A  70
 None
SO4  A 903 (-4.2A)
None
None
 1.08A 4udaA-1e3hA:
0.0		 4udaA-1e3hA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 4 ASN A 476
SER A 576
ALA A 477
VAL A 479
 None
 1.17A 4x1kC-1e3hA:
undetectable		 4x1kC-1e3hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 5 ALA A 486
THR A 471
VAL A 438
ILE A 435
 None
 0.95A 4xe3A-1e3hA:
0.0		 4xe3A-1e3hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 5 ALA A 219
THR A 209
VAL A 438
ILE A 210
 None
 0.94A 4xe3B-1e3hA:
0.0		 4xe3B-1e3hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 5 ALA A 486
THR A 471
VAL A 438
ILE A 435
 None
 0.94A 4xe3B-1e3hA:
0.0		 4xe3B-1e3hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 THR A 123
LEU A  48
GLY A  35
SER A 144
ALA A  37
 None
 1.13A 4ypmA-1e3hA:
3.8		 4ypmA-1e3hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 6 PHE A 529
LYS A 527
GLY A 525
ALA A 532
 None
 1.02A 4yshB-1e3hA:
0.0		 4yshB-1e3hA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 510
GLU A 513
ARG A 339
ILE A 561
GLY A 487
 None
 1.12A 5gtrA-1e3hA:
undetectable		 5gtrA-1e3hA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 6 PHE A 406
ASN A 405
ARG A 423
GLY A 426
 None
 0.90A 5o4yA-1e3hA:
undetectable		 5o4yA-1e3hA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 7 TYR A 133
VAL A  47
VAL A  70
ALA A 122
 SO4  A 903 (-3.8A)
None
None
None
 0.76A 5ospA-1e3hA:
0.0		 5ospA-1e3hA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		4 / 7 TYR A 133
VAL A  47
VAL A  70
ALA A 122
 SO4  A 903 (-3.8A)
None
None
None
 0.75A 5osrA-1e3hA:
undetectable		 5osrA-1e3hA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 9 GLY A 511
ALA A 512
GLY A 460
GLU A 371
SER A 458
 None
None
SO4  A 904 ( 4.3A)
None
SO4  A 904 ( 4.1A)
 1.23A 5vw4A-1e3hA:
undetectable		 5vw4A-1e3hA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		5 / 8 GLY A 511
ALA A 512
GLY A 460
GLU A 371
SER A 458
 None
None
SO4  A 904 ( 4.3A)
None
SO4  A 904 ( 4.1A)
 1.20A 5vw9A-1e3hA:
undetectable		 5vw9A-1e3hA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		3 / 3 VAL A 436
TYR A 400
GLU A 204
 None
None
SO4  A 906 (-3.4A)
 0.92A 5zmqD-1e3hA:
0.0
5zmqE-1e3hA:
undetectable		 5zmqD-1e3hA:
14.34
5zmqE-1e3hA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		3 / 3 ASP A  42
ARG A  20
ASP A 130
 None
 0.89A 5zvgA-1e3hA:
undetectable		 5zvgA-1e3hA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE
(Streptomyces
antibioticus) 		3 / 3 ASP A  42
ARG A  20
ASP A 130
 None
 0.84A 5zvgB-1e3hA:
undetectable		 5zvgB-1e3hA:
20.56