SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 8 GLU A 146
LEU A 125
ALA A 331
THR A 328
 None
 0.87A 1ie4B-1e3jA:
0.0
1ie4D-1e3jA:
undetectable		 1ie4B-1e3jA:
17.33
1ie4D-1e3jA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 5 LEU A 173
GLY A 257
ILE A 230
ILE A 233
 None
 0.83A 2q9rA-1e3jA:
undetectable		 2q9rA-1e3jA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		3 / 3 LEU A 325
LEU A   6
ARG A  21
 None
 0.69A 3hcnB-1e3jA:
undetectable		 3hcnB-1e3jA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 12 ALA A 149
SER A  69
ASN A   5
LEU A 125
GLY A  65
 None
 1.21A 3nrrB-1e3jA:
2.5		 3nrrB-1e3jA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 10 GLY A 192
ALA A 193
VAL A 243
VAL A 174
VAL A 172
 None
 1.13A 3nu9B-1e3jA:
undetectable		 3nu9B-1e3jA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 12 VAL A 207
LEU A 318
VAL A 174
GLY A 176
ALA A 177
 None
None
None
PO4  A 903 ( 3.9A)
PO4  A 903 (-3.9A)
 1.04A 3rr3B-1e3jA:
0.0		 3rr3B-1e3jA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 11 THR A 118
PRO A 120
THR A 114
GLY A  93
PRO A  92
 None
 1.47A 3t8nD-1e3jA:
0.0
3t8nF-1e3jA:
0.0		 3t8nD-1e3jA:
17.61
3t8nF-1e3jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 12 LEU A 325
GLY A  65
ILE A 347
ASP A 122
LEU A  16
 None
 0.99A 3uj6A-1e3jA:
5.9		 3uj6A-1e3jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 6 CYH A  41
GLY A  42
ASP A  44
ILE A  64
 ZN  A 902 (-2.4A)
None
None
None
 1.00A 3w9tF-1e3jA:
0.0		 3w9tF-1e3jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		3 / 3 GLU A 146
TYR A  37
SER A 348
 None
 0.72A 4at0A-1e3jA:
2.7		 4at0A-1e3jA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 8 GLY A  51
ILE A  57
VAL A  58
PRO A 119
 None
 0.87A 4e1vG-1e3jA:
undetectable		 4e1vG-1e3jA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 10 GLY A 265
ASN A 242
ALA A 193
VAL A 243
MET A 268
 None
 1.28A 4j4vA-1e3jA:
0.0
4j4vE-1e3jA:
0.0		 4j4vA-1e3jA:
21.39
4j4vE-1e3jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 9 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
 None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
 1.14A 4mmbA-1e3jA:
0.0		 4mmbA-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 9 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
 None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
 1.19A 4mmeA-1e3jA:
0.0		 4mmeA-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 9 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
 None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
 1.20A 4mmeB-1e3jA:
0.0		 4mmeB-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 9 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
 None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
 1.18A 4mmfA-1e3jA:
undetectable		 4mmfA-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		5 / 9 VAL A 219
ALA A 199
GLY A 257
SER A 248
GLY A 176
 None
PO4  A 903 (-3.4A)
None
None
PO4  A 903 ( 3.9A)
 1.20A 4mmfB-1e3jA:
0.0		 4mmfB-1e3jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 8 LEU A 151
VAL A 183
LEU A 186
GLY A 311
 None
 0.81A 4r3aA-1e3jA:
undetectable		 4r3aA-1e3jA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 5 TYR A 301
TYR A 107
GLU A 152
ASP A  44
 None
None
ZN  A 902 ( 3.9A)
None
 1.37A 4x61A-1e3jA:
4.6		 4x61A-1e3jA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 6 TYR A  47
PHE A  56
THR A 118
GLY A  51
 None
 1.21A 5mraA-1e3jA:
0.0
5mraB-1e3jA:
undetectable		 5mraA-1e3jA:
19.10
5mraB-1e3jA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE
(Bemisia
argentifolii) 		4 / 9 HIS A 321
LEU A 154
VAL A 185
SER A 184
 None
 0.97A 6c2mD-1e3jA:
0.0		 6c2mD-1e3jA:
14.29