SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 11 HIS A 382
ASP A 451
GLY A 454
TYR A 480
VAL A 477
 None
 1.33A 1axwB-1e43A:
0.0		 1axwB-1e43A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		6 / 12 TYR A  54
LEU A 196
ASP A 231
ALA A 232
HIS A 327
ASP A 328
 None
 0.77A 1dedA-1e43A:
26.2		 1dedA-1e43A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 TYR A  54
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.70A 1dedB-1e43A:
24.2		 1dedB-1e43A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 6 ALA A 295
TRP A 411
ARG A 354
LEU A 292
 None
 1.07A 1gahA-1e43A:
undetectable		 1gahA-1e43A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ALA A 121
VAL A 118
TRP A 182
 None
 0.91A 1gmkC-1e43A:
undetectable
1gmkD-1e43A:
undetectable		 1gmkC-1e43A:
4.90
1gmkD-1e43A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ALA A 294
VAL A 339
TRP A 342
 None
 0.90A 1grmA-1e43A:
undetectable		 1grmA-1e43A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ALA A 294
VAL A 339
TRP A 342
 None
 0.90A 1grmB-1e43A:
undetectable		 1grmB-1e43A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 12 TRP A  11
ALA A 105
ALA A 232
GLU A 261
ASP A 328
 None
 0.84A 1kxhA-1e43A:
28.5		 1kxhA-1e43A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 12 TRP A  11
HIS A 103
ALA A 232
GLU A 261
ASP A 328
 None
 0.61A 1kxhA-1e43A:
28.5		 1kxhA-1e43A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ALA A 210
VAL A 208
TRP A 153
 None
 0.79A 1micA-1e43A:
undetectable
1micB-1e43A:
undetectable		 1micA-1e43A:
4.90
1micB-1e43A:
4.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		9 / 12 TRP A  11
TYR A  54
ARG A 229
ASP A 231
LYS A 234
GLU A 261
TRP A 263
HIS A 327
ASP A 328
 None
 0.93A 1mxdA-1e43A:
40.0		 1mxdA-1e43A:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		9 / 12 TRP A  11
TYR A  54
HIS A 103
ARG A 229
ASP A 231
LYS A 234
GLU A 261
HIS A 327
ASP A 328
 None
 0.53A 1mxdA-1e43A:
40.0		 1mxdA-1e43A:
31.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 12 SER A 296
GLN A 293
GLY A 299
GLY A 301
GLY A 300
 None
None
None
CA  A 504 ( 4.3A)
CA  A 504 (-4.1A)
 0.91A 1uakA-1e43A:
undetectable		 1uakA-1e43A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 12 THR A 429
LEU A 346
ILE A 428
MET A 304
TRP A 342
 None
 1.35A 1wsvB-1e43A:
0.0		 1wsvB-1e43A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 11 TYR A  54
ASP A 231
HIS A 327
ASP A 328
TRP A  11
 None
 1.03A 2owcA-1e43A:
13.6		 2owcA-1e43A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 11 TYR A  54
ASP A 231
HIS A 327
ASP A 328
TRP A  11
 None
 1.05A 2owwA-1e43A:
13.5		 2owwA-1e43A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 LEU A 196
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.59A 3aicA-1e43A:
14.0		 3aicA-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 LEU A 196
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.57A 3aicB-1e43A:
13.9		 3aicB-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
TYR A  54
 None
 0.57A 3aicC-1e43A:
14.2		 3aicC-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 LEU A 196
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.64A 3aicD-1e43A:
14.1		 3aicD-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 LEU A 196
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.62A 3aicE-1e43A:
14.3		 3aicE-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 LEU A 196
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.60A 3aicF-1e43A:
14.0		 3aicF-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 LEU A 196
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.57A 3aicG-1e43A:
14.1		 3aicG-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 12 LEU A 196
ARG A 229
ASP A 231
ALA A 232
GLU A 261
HIS A 327
ASP A 328
 None
 0.65A 3aicH-1e43A:
14.2		 3aicH-1e43A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 GLY A 423
GLY A 397
GLY A 415
 None
 0.40A 3bogD-1e43A:
0.0		 3bogD-1e43A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.50A 3el0A-1e43A:
undetectable		 3el0A-1e43A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 10 LEU A 288
ALA A 347
ILE A 384
PRO A 359
THR A 322
 None
 0.99A 3el5A-1e43A:
undetectable		 3el5A-1e43A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.54A 3em6A-1e43A:
0.0		 3em6A-1e43A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 12 VAL A 477
ILE A 452
ILE A  33
HIS A  29
TYR A 367
 None
 1.24A 3g8iA-1e43A:
0.0		 3g8iA-1e43A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 7 HIS A  19
LEU A   5
GLN A 360
PHE A 362
 None
 0.95A 3jwqC-1e43A:
undetectable		 3jwqC-1e43A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 10 ILE A 428
ALA A 347
LEU A 307
LEU A 292
VAL A 339
 None
 1.22A 3o02A-1e43A:
0.0
3o02B-1e43A:
0.0		 3o02A-1e43A:
20.16
3o02B-1e43A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.49A 3so9A-1e43A:
undetectable		 3so9A-1e43A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 7 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.46A 3t3cA-1e43A:
undetectable		 3t3cA-1e43A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 5 GLU A 271
GLY A 268
TYR A 262
GLN A 264
 None
 1.46A 3w9tD-1e43A:
0.0		 3w9tD-1e43A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 5 GLU A 271
GLY A 268
TYR A 262
GLN A 264
 None
 1.45A 3w9tE-1e43A:
0.0		 3w9tE-1e43A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 5 GLU A 271
GLY A 268
TYR A 262
GLN A 264
 None
 1.50A 3w9tG-1e43A:
0.0		 3w9tG-1e43A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A 354
ARG A 413
TRP A 411
 None
 1.08A 4b7nA-1e43A:
undetectable		 4b7nA-1e43A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A 354
ARG A 413
TRP A 411
 None
 1.17A 4cpzC-1e43A:
undetectable		 4cpzC-1e43A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A 354
ARG A 413
TRP A 411
 None
 1.14A 4cpzE-1e43A:
undetectable		 4cpzE-1e43A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A 354
ARG A 413
TRP A 411
 None
 1.07A 4cpzF-1e43A:
undetectable		 4cpzF-1e43A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A 354
ARG A 413
TRP A 411
 None
 1.12A 4cpzG-1e43A:
undetectable		 4cpzG-1e43A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A 354
ARG A 413
TRP A 411
 None
 1.10A 4cpzH-1e43A:
undetectable		 4cpzH-1e43A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.54A 4eyrB-1e43A:
undetectable		 4eyrB-1e43A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 TYR A 480
ARG A 456
SER A 478
 None
 1.10A 4khpI-1e43A:
0.0
4khpJ-1e43A:
0.0		 4khpI-1e43A:
15.53
4khpJ-1e43A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 6 ASP A 183
ASP A 159
ALA A 161
ASP A 194
 NA  A 505 ( 3.0A)
CA  A 502 ( 2.2A)
None
NA  A 505 ( 2.3A)
 1.20A 4mdbA-1e43A:
0.9		 4mdbA-1e43A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 5 ILE A 387
LEU A 352
ASP A 365
GLU A 385
 None
 1.07A 4nkxB-1e43A:
undetectable		 4nkxB-1e43A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 GLU A 336
TYR A  12
GLU A 376
 None
 0.79A 4ryaA-1e43A:
0.0		 4ryaA-1e43A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 LYS A  21
ARG A  22
HIS A  19
 None
 1.23A 4zbrA-1e43A:
0.0		 4zbrA-1e43A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 12 ARG A 229
ASP A 231
GLU A 261
HIS A 327
ASP A 328
 None
 0.48A 5csyB-1e43A:
6.0		 5csyB-1e43A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 8 ILE A 377
GLN A 293
SER A 337
GLU A 336
 None
 1.09A 5dqyA-1e43A:
0.0		 5dqyA-1e43A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 6 PHE A 290
SER A 296
ALA A 294
LEU A 292
 None
 1.28A 5dzkB-1e43A:
2.6
5dzkP-1e43A:
undetectable		 5dzkB-1e43A:
19.33
5dzkP-1e43A:
0.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 7 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.48A 5kqyB-1e43A:
undetectable		 5kqyB-1e43A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 8 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.46A 5kr1B-1e43A:
undetectable		 5kr1B-1e43A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		3 / 3 HIS A 235
SER A 187
ARG A 123
 None
 0.98A 5u63A-1e43A:
undetectable		 5u63A-1e43A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		4 / 5 ASN A 291
VAL A 283
LEU A 274
SER A 314
 None
 1.22A 6a7pA-1e43A:
undetectable		 6a7pA-1e43A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 8 TYR A 156
GLY A 177
LYS A 180
ASP A 202
ASP A 204
HIS A 205
PRO A 206
 None
None
None
CA  A 502 (-2.9A)
CA  A 502 (-3.2A)
None
None
 0.71A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 7 GLY A 299
GLY A 300
TRP A 342
GLY A 431
PRO A 432
GLY A 474
GLY A 475
 None
CA  A 504 (-4.1A)
None
None
None
None
None
 0.31A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		6 / 7 GLY A 301
GLY A 300
GLY A 431
PRO A 432
GLY A 474
GLY A 475
 CA  A 504 ( 4.3A)
CA  A 504 (-4.1A)
None
None
None
None
 1.42A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 6 GLY A   3
THR A  36
GLN A  94
TYR A  96
TYR A 358
 None
 0.35A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 7 LYS A  68
GLY A 106
TRP A 136
ASP A 162
TRP A 163
MET A 197
TYR A 198
 None
 0.45A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		11 / 12 TRP A  11
TYR A  54
HIS A 103
GLU A 189
TYR A 193
LEU A 196
MET A 197
ASP A 231
HIS A 235
HIS A 327
ASP A 328
 None
 0.65A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		11 / 12 TRP A  11
TYR A  54
HIS A 103
TYR A 193
LEU A 196
MET A 197
ASP A 231
LYS A 234
HIS A 235
HIS A 327
ASP A 328
 None
 0.26A 6ag0A-1e43A:
59.0		 6ag0A-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 8 TYR A 156
GLY A 177
LYS A 180
ASP A 202
ASP A 204
HIS A 205
PRO A 206
 None
None
None
CA  A 502 (-2.9A)
CA  A 502 (-3.2A)
None
None
 0.74A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 6 GLY A   3
THR A  36
GLN A  94
TYR A  96
TYR A 358
 None
 0.35A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		5 / 6 GLY A 299
TRP A 342
GLY A 431
PRO A 432
GLY A 475
 None
 0.27A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		11 / 12 TRP A  11
GLU A 189
TYR A 193
LEU A 196
MET A 197
ASP A 231
LYS A 234
HIS A 235
HIS A 327
ASP A 328
GLN A 333
 None
 0.79A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 1e43 ALPHA-AMYLASE
(Bacillus
amyloliquefacien
s) 		7 / 7 LYS A  68
GLY A 106
TRP A 136
ASP A 162
TRP A 163
MET A 197
TYR A 198
 None
 0.49A 6ag0C-1e43A:
59.0		 6ag0C-1e43A:
11.73