SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		4 / 5 TYR P 113
GLU P 173
PHE P 206
ALA P 117
 None
 1.50A 1oniE-1e4aP:
0.0
1oniF-1e4aP:
0.1		 1oniE-1e4aP:
20.74
1oniF-1e4aP:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		5 / 9 ASN P 146
ILE P 123
GLY P 120
ALA P 118
THR P 150
 None
 1.14A 2dtjA-1e4aP:
0.0
2dtjB-1e4aP:
0.0		 2dtjA-1e4aP:
21.52
2dtjB-1e4aP:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		5 / 12 LEU P 157
GLY P 156
LEU P 151
ALA P 126
LEU P 144
 None
 0.98A 3gwvA-1e4aP:
0.0		 3gwvA-1e4aP:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		4 / 4 HIS P  94
GLU P 175
HIS P  97
LEU P 104
 ZN  P 304 (-3.3A)
None
None
None
 1.44A 4m2rA-1e4aP:
undetectable		 4m2rA-1e4aP:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		5 / 12 ASN P  29
VAL P  30
MET P  17
ASN P  23
GLY P 156
 SO4  P 301 (-3.8A)
BME  P 303 ( 4.8A)
None
BME  P 303 ( 4.4A)
None
 1.04A 4qckA-1e4aP:
0.0		 4qckA-1e4aP:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		4 / 7 ALA P 100
LEU P 182
LEU P 185
ILE P 103
 None
 0.72A 4ubsA-1e4aP:
undetectable		 4ubsA-1e4aP:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		4 / 5 GLY P  28
THR P  26
HIS P  92
GLY P 156
 None
None
ZN  P 304 (-3.3A)
None
 1.11A 4v20A-1e4aP:
0.0		 4v20A-1e4aP:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		5 / 12 CYH P  14
LEU P  15
LEU P  50
VAL P  30
ILE P  55
 BME  P 303 (-2.0A)
None
None
BME  P 303 ( 4.8A)
None
 0.99A 4x20B-1e4aP:
undetectable		 4x20B-1e4aP:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		4 / 5 HIS P  92
HIS P  94
HIS P 155
PHE P  76
 ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
None
 1.17A 5zrdB-1e4aP:
undetectable		 5zrdB-1e4aP:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		4 / 5 HIS P  92
HIS P  94
HIS P 155
PHE P  76
 ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
None
 1.23A 5zrdC-1e4aP:
undetectable		 5zrdC-1e4aP:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE
(Escherichia
coli) 		4 / 5 HIS P  92
HIS P  94
HIS P 155
PHE P  76
 ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
None
 1.18A 5zrdD-1e4aP:
undetectable		 5zrdD-1e4aP:
16.30