SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 6 LEU B 111
ILE B 117
ASP B  72
PRO B  71
 None
 1.06A 1ditH-1e4eB:
0.0
1ditP-1e4eB:
undetectable		 1ditH-1e4eB:
20.34
1ditP-1e4eB:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 10 GLY B 121
SER B 126
GLY B 103
ALA B 128
THR B 308
 None
 1.16A 1gtfJ-1e4eB:
undetectable
1gtfK-1e4eB:
undetectable		 1gtfJ-1e4eB:
12.83
1gtfK-1e4eB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 10 SER B  20
GLY B 311
GLU B  15
GLY B 100
GLU B 104
 None
PHY  B 355 (-3.3A)
None
None
PHY  B 355 ( 4.6A)
 0.85A 1mehA-1e4eB:
undetectable		 1mehA-1e4eB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		3 / 3 GLY B 216
ASP B 232
ASN B 304
 None
None
ADP  B 350 (-3.3A)
 0.61A 1vq1A-1e4eB:
undetectable		 1vq1A-1e4eB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 11 GLY B  12
SER B 102
GLY B 100
HIS B  99
PHE B 312
 None
None
None
PHY  B 355 ( 3.8A)
None
 1.25A 2hmaA-1e4eB:
undetectable		 2hmaA-1e4eB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		3 / 3 TYR B 280
TYR B 318
GLY B 221
 None
 0.75A 3eteB-1e4eB:
2.6
3eteD-1e4eB:
3.4
3eteF-1e4eB:
3.4		 3eteB-1e4eB:
21.71
3eteD-1e4eB:
21.71
3eteF-1e4eB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		3 / 3 SER B  20
GLY B  11
SER B  96
 None
 0.61A 3loqA-1e4eB:
1.6		 3loqA-1e4eB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 5 ASP B  18
GLU B  60
THR B  44
SER B 177
 None
None
None
PHY  B 355 ( 3.6A)
 1.45A 3p2kC-1e4eB:
undetectable		 3p2kC-1e4eB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 11 GLY B  12
SER B 102
GLY B 311
ASN B 307
MET B 131
 None
None
PHY  B 355 (-3.3A)
MG  B 360 ( 2.4A)
None
 1.35A 3v3nD-1e4eB:
3.1		 3v3nD-1e4eB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 10 PHE B 112
SER B 115
GLY B 110
ALA B 218
MET B 322
 None
 1.45A 4fe1A-1e4eB:
0.0
4fe1J-1e4eB:
0.0		 4fe1A-1e4eB:
18.89
4fe1J-1e4eB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		3 / 3 CYH B 130
ASN B 307
LYS B 133
 None
MG  B 360 ( 2.4A)
ADP  B 350 (-2.9A)
 1.39A 4k50A-1e4eB:
0.0		 4k50A-1e4eB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 6 ARG B 290
ASP B 292
LEU B 309
SER B  23
 PHY  B 355 (-3.2A)
PHY  B 355 ( 4.7A)
None
None
 1.03A 4ot2A-1e4eB:
1.0		 4ot2A-1e4eB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		5 / 12 VAL B 260
PRO B 261
ALA B 262
ILE B 272
GLN B 273
 None
 1.00A 5hgcA-1e4eB:
0.0		 5hgcA-1e4eB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 5 ILE B  41
PHE B 112
SER B  96
ALA B   7
 None
 0.98A 5msdA-1e4eB:
undetectable		 5msdA-1e4eB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		3 / 3 LYS B 203
LYS B 133
SER B 134
 SO4  B1342 (-3.0A)
ADP  B 350 (-2.9A)
None
 1.27A 5odiA-1e4eB:
3.9		 5odiA-1e4eB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 7 SER B 115
ALA B  94
ILE B   4
LEU B 341
 None
 0.83A 5te8A-1e4eB:
0.0		 5te8A-1e4eB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA
(Enterococcus
faecium) 		4 / 8 SER B 115
ALA B  94
ILE B   4
LEU B 341
 None
 0.80A 5te8B-1e4eB:
undetectable		 5te8B-1e4eB:
20.33