SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.73A 1c8lA-1e4oA:
51.0		 1c8lA-1e4oA:
42.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.77A 1gfzA-1e4oA:
50.6		 1gfzA-1e4oA:
42.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 LEU A  42
LEU A  79
GLY A  75
LEU A  98
 None
 0.85A 1gtiA-1e4oA:
0.2		 1gtiA-1e4oA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 4 LEU A 255
PRO A 257
LEU A 144
ARG A 534
 None
None
None
GLC  A 996 (-4.1A)
 1.39A 1hrkB-1e4oA:
0.5		 1hrkB-1e4oA:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.83A 1l5qA-1e4oA:
49.9		 1l5qA-1e4oA:
42.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.82A 1l5qB-1e4oA:
48.4		 1l5qB-1e4oA:
42.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.86A 1l7xA-1e4oA:
48.6		 1l7xA-1e4oA:
42.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.87A 1l7xB-1e4oA:
48.4		 1l7xB-1e4oA:
42.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 GLU A 242
GLU A 249
HIS A 224
HIS A 226
PHE A 228
 None
 1.47A 1mjlA-1e4oA:
undetectable
1mjlB-1e4oA:
undetectable		 1mjlA-1e4oA:
11.11
1mjlB-1e4oA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 4 GLY A 731
SER A 729
VAL A 740
LEU A 707
 None
 1.28A 1yajB-1e4oA:
1.8		 1yajB-1e4oA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLY A 734
LEU A 707
MET A 741
HIS A 542
LEU A 580
 None
 1.17A 1zgyA-1e4oA:
0.0		 1zgyA-1e4oA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 4 ILE A  70
ASP A 159
LEU A 255
ARG A 455
 None
 1.33A 2a7qA-1e4oA:
2.5		 2a7qA-1e4oA:
15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 ASN A 112
LEU A 115
TYR A 256
ASP A 259
ARG A 268
ARG A 534
HIS A 536
ALA A 575
 GLC  A 996 (-3.5A)
GLC  A 997 (-3.8A)
GLC  A 996 (-3.8A)
GLC  A 995 ( 4.4A)
GLC  A 995 (-3.3A)
GLC  A 996 (-4.1A)
GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
 0.88A 2ecpA-1e4oA:
59.5		 2ecpA-1e4oA:
98.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		9 / 10 ASN A 112
LEU A 115
TYR A 256
ASP A 259
ARG A 268
ASP A 307
HIS A 309
ARG A 534
ALA A 575
 GLC  A 996 (-3.5A)
GLC  A 997 (-3.8A)
GLC  A 996 (-3.8A)
GLC  A 995 ( 4.4A)
GLC  A 995 (-3.3A)
GLC  A 997 (-3.6A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
GLC  A 995 (-3.5A)
 0.84A 2ecpA-1e4oA:
59.5		 2ecpA-1e4oA:
98.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 ASN A 112
LEU A 115
TYR A 256
ASP A 259
ARG A 268
ARG A 534
HIS A 536
ALA A 575
 GLC  A 996 (-3.5A)
GLC  A 997 (-3.8A)
GLC  A 996 (-3.8A)
GLC  A 995 ( 4.4A)
GLC  A 995 (-3.3A)
GLC  A 996 (-4.1A)
GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
 0.90A 2ecpB-1e4oA:
60.2		 2ecpB-1e4oA:
98.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		9 / 10 ASN A 112
LEU A 115
TYR A 256
ASP A 259
ARG A 268
ASP A 307
HIS A 309
ARG A 534
ALA A 575
 GLC  A 996 (-3.5A)
GLC  A 997 (-3.8A)
GLC  A 996 (-3.8A)
GLC  A 995 ( 4.4A)
GLC  A 995 (-3.3A)
GLC  A 997 (-3.6A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
GLC  A 995 (-3.5A)
 0.87A 2ecpB-1e4oA:
60.2		 2ecpB-1e4oA:
98.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 GLY A 114
ASP A 658
THR A 641
GLY A 642
GLN A 630
 PLP  A 999 ( 3.6A)
None
GLC  A 998 ( 4.0A)
PLP  A 999 (-3.4A)
None
 1.42A 2hmaA-1e4oA:
1.3		 2hmaA-1e4oA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 4 LEU A 255
PRO A 257
LEU A 144
ARG A 534
 None
None
None
GLC  A 996 (-4.1A)
 1.39A 2hrcA-1e4oA:
2.0		 2hrcA-1e4oA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 4 LEU A 255
PRO A 257
LEU A 144
ARG A 534
 None
None
None
GLC  A 996 (-4.1A)
 1.40A 2hrcB-1e4oA:
3.4		 2hrcB-1e4oA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 7 PHE A  10
LEU A  91
LEU A  98
PRO A 167
ARG A  72
 None
 1.41A 2jn3A-1e4oA:
undetectable		 2jn3A-1e4oA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 TRP A 168
SER A  90
ALA A  41
LEU A  42
 None
 1.05A 2o01A-1e4oA:
0.0		 2o01A-1e4oA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 4 LEU A 255
PRO A 257
LEU A 144
ARG A 534
 None
None
None
GLC  A 996 (-4.1A)
 1.39A 2pnjB-1e4oA:
3.6		 2pnjB-1e4oA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 LEU A  36
ASN A 165
ARG A  32
 None
 0.85A 2qhfA-1e4oA:
0.0		 2qhfA-1e4oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ILE A 314
THR A 311
LEU A 409
HIS A 367
LEU A 364
 None
 1.03A 2qo5A-1e4oA:
0.0		 2qo5A-1e4oA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 101
LEU A 102
GLN A 459
ARG A 455
LEU A  42
 None
 1.35A 2w8yB-1e4oA:
undetectable		 2w8yB-1e4oA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 8 LEU A 144
GLY A 113
LEU A  69
GLY A  71
ASP A 107
 None
GLC  A 997 (-3.3A)
None
None
None
 1.27A 2yfxA-1e4oA:
undetectable		 2yfxA-1e4oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 VAL A 420
ASP A 307
TYR A  63
ASN A 449
 None
GLC  A 997 (-3.6A)
None
GLC  A 998 (-3.3A)
 1.46A 2zs9A-1e4oA:
0.2		 2zs9A-1e4oA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 MET A 726
ILE A 730
LEU A 727
LEU A 549
LEU A 703
 None
 1.02A 3a50D-1e4oA:
0.0		 3a50D-1e4oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 ASP A 479
TRP A 476
ARG A 454
SER A 125
 None
 1.47A 3ckzA-1e4oA:
undetectable		 3ckzA-1e4oA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 101
LEU A 102
GLN A 459
ARG A 455
LEU A  42
 None
 1.33A 3d90A-1e4oA:
undetectable		 3d90A-1e4oA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.76A 3dd1A-1e4oA:
49.7		 3dd1A-1e4oA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.79A 3dd1B-1e4oA:
48.0		 3dd1B-1e4oA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.79A 3ddsA-1e4oA:
50.0		 3ddsA-1e4oA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.77A 3ddsB-1e4oA:
47.9		 3ddsB-1e4oA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.80A 3ddwA-1e4oA:
50.1		 3ddwA-1e4oA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 HIS A 536
ALA A 575
GLY A 577
TYR A 578
 GLC  A 995 (-4.4A)
GLC  A 995 (-3.5A)
None
GLC  A 995 (-3.8A)
 0.80A 3ddwB-1e4oA:
48.3		 3ddwB-1e4oA:
42.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 TYR A 538
THR A 633
ILE A 631
THR A 448
GLU A 663
 None
 1.22A 3qelA-1e4oA:
3.3
3qelB-1e4oA:
2.0		 3qelA-1e4oA:
17.52
3qelB-1e4oA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 GLU A 663
VAL A 662
LEU A 657
LEU A 427
 None
 0.92A 3qeoB-1e4oA:
2.0		 3qeoB-1e4oA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 8 ILE A 548
ILE A 588
PHE A 570
LEU A 710
VAL A 706
 None
 1.13A 3ua5A-1e4oA:
1.4		 3ua5A-1e4oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 SER A 425
ASP A 786
ASP A 781
ILE A 784
 None
 1.28A 3uj7B-1e4oA:
1.6		 3uj7B-1e4oA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 THR A 452
PHE A 778
GLY A 776
GLY A 642
ASN A 661
 None
None
None
PLP  A 999 (-3.4A)
None
 1.22A 3v3oA-1e4oA:
undetectable		 3v3oA-1e4oA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 ILE A 627
GLU A 629
TYR A 747
VAL A 706
 None
 1.10A 4a97D-1e4oA:
2.7		 4a97D-1e4oA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ILE A 791
GLN A 304
ILE A 303
GLU A 301
 None
 1.08A 4a99D-1e4oA:
undetectable		 4a99D-1e4oA:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 TRP A 329
ARG A 366
GLU A 373
ARG A 377
 None
 0.75A 4bqfB-1e4oA:
47.6		 4bqfB-1e4oA:
42.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 ILE A 664
ALA A 660
GLY A 640
GLY A 635
ASN A 661
 None
None
PLP  A 999 ( 3.2A)
None
None
 1.29A 4e47C-1e4oA:
undetectable		 4e47C-1e4oA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 ARG A 117
ILE A 451
ASP A 481
LEU A 480
GLY A 776
 None
 1.50A 4eb4C-1e4oA:
0.0		 4eb4C-1e4oA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLY A 734
LEU A 707
MET A 741
HIS A 542
LEU A 580
 None
 1.12A 4emaA-1e4oA:
0.0		 4emaA-1e4oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 ILE A 314
THR A 311
LEU A 409
VAL A 398
VAL A 360
 None
 1.13A 4g1bC-1e4oA:
4.7		 4g1bC-1e4oA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 ASN A 408
ALA A 407
VAL A 417
TYR A 342
 None
 1.00A 4ijiH-1e4oA:
0.0		 4ijiH-1e4oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 ILE A 664
ALA A 660
GLY A 640
GLY A 635
ASN A 661
 None
None
PLP  A 999 ( 3.2A)
None
None
 1.30A 4jdsC-1e4oA:
undetectable		 4jdsC-1e4oA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLY A 111
GLY A 116
ILE A  70
ALA A 120
ASP A 107
 None
GLC  A 997 (-4.8A)
None
None
None
 1.20A 4kicA-1e4oA:
undetectable		 4kicA-1e4oA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 LEU A 123
PHE A 122
HIS A 345
TYR A 787
 None
None
GLC  A 998 (-4.3A)
None
 1.10A 4pahA-1e4oA:
undetectable		 4pahA-1e4oA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 THR A 308
ASN A 375
PHE A 378
 None
 0.78A 4pd9A-1e4oA:
0.8		 4pd9A-1e4oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 PHE A  10
ILE A  96
TYR A  84
LEU A  98
LEU A  42
 None
 1.38A 4qztC-1e4oA:
0.0		 4qztC-1e4oA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ASP A 307
LEU A 138
PHE A  68
GLY A 116
GLU A 637
 GLC  A 997 (-3.6A)
None
None
GLC  A 997 (-4.8A)
GLC  A 998 (-3.6A)
 1.29A 4retA-1e4oA:
2.1		 4retA-1e4oA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLY A 208
TYR A 209
SER A   1
ASP A 124
ASN A  77
 None
 1.32A 4ymgB-1e4oA:
2.6		 4ymgB-1e4oA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 5 GLY A 114
GLY A 640
GLU A 637
 PLP  A 999 ( 3.6A)
PLP  A 999 ( 3.2A)
GLC  A 998 (-3.6A)
 0.52A 4z2eA-1e4oA:
undetectable
4z2eD-1e4oA:
2.3		 4z2eA-1e4oA:
21.84
4z2eD-1e4oA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 VAL A 411
TYR A 273
ILE A 197
PRO A 310
 None
 1.16A 4ze1A-1e4oA:
0.0		 4ze1A-1e4oA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ALA A 550
ARG A 556
ALA A 705
GLU A 557
 None
 1.42A 5a06C-1e4oA:
3.1
5a06D-1e4oA:
3.0		 5a06C-1e4oA:
20.80
5a06D-1e4oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 10 ALA A 313
ILE A 312
CYH A 410
GLY A 413
LEU A 409
 None
 1.44A 5ajqB-1e4oA:
undetectable		 5ajqB-1e4oA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ALA A 119
GLY A 111
GLY A 116
GLY A 114
LEU A 110
 None
None
GLC  A 997 (-4.8A)
PLP  A 999 ( 3.6A)
None
 0.93A 5c0oH-1e4oA:
2.5		 5c0oH-1e4oA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 TYR A 538
THR A 633
ILE A 631
THR A 448
GLU A 663
 None
 1.22A 5ewjC-1e4oA:
3.7
5ewjD-1e4oA:
2.6		 5ewjC-1e4oA:
17.38
5ewjD-1e4oA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 TYR A  63
PHE A 122
ILE A 791
TRP A 792
 None
 0.95A 5hw8H-1e4oA:
undetectable		 5hw8H-1e4oA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 VAL A 179
GLN A 275
CYH A 278
 None
 0.74A 5icxA-1e4oA:
0.0
5icxE-1e4oA:
undetectable		 5icxA-1e4oA:
14.66
5icxE-1e4oA:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 SER A 783
TYR A  63
SER A 639
ASN A 449
 None
None
GLC  A 998 (-4.9A)
GLC  A 998 (-3.3A)
 1.23A 5l1fC-1e4oA:
4.1		 5l1fC-1e4oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 LYS A 253
GLN A 244
ASN A 247
 None
 0.88A 5l2tA-1e4oA:
0.0		 5l2tA-1e4oA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 THR A 134
PRO A 216
ASP A 203
 None
 0.83A 5l8dB-1e4oA:
1.0		 5l8dB-1e4oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 LEU A 110
ARG A 163
PHE A 169
TRP A 161
 None
 1.28A 5m10A-1e4oA:
0.3		 5m10A-1e4oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 LEU A 110
PHE A 169
LEU A 217
TRP A 161
 None
 1.23A 5m10A-1e4oA:
0.3		 5m10A-1e4oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 THR A 134
PRO A 216
ASP A 203
 None
 0.83A 5mwuB-1e4oA:
1.0		 5mwuB-1e4oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		7 / 10 GLY A 114
HIS A 345
VAL A 420
ASN A 449
LYS A 539
GLU A 637
GLY A 640
 PLP  A 999 ( 3.6A)
GLC  A 998 (-4.3A)
None
GLC  A 998 (-3.3A)
GLC  A 998 (-4.0A)
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.73A 5vncC-1e4oA:
16.8		 5vncC-1e4oA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ASP A 356
ARG A 354
GLN A 272
MET A  66
 None
 1.35A 5zrfB-1e4oA:
1.6		 5zrfB-1e4oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 ILE A  70
VAL A 206
ALA A 127
THR A 128
 None
 0.92A 6cduC-1e4oA:
undetectable
6cduD-1e4oA:
undetectable		 6cduC-1e4oA:
18.06
6cduD-1e4oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 ILE A  70
VAL A 206
ALA A 127
THR A 128
 None
 0.88A 6cduD-1e4oA:
1.8
6cduE-1e4oA:
1.8		 6cduD-1e4oA:
18.06
6cduE-1e4oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 ALA A 127
THR A 128
ILE A  70
VAL A 206
 None
 0.96A 6cduF-1e4oA:
0.0
6cduJ-1e4oA:
0.0		 6cduF-1e4oA:
18.06
6cduJ-1e4oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 707
LEU A 703
ALA A 587
LEU A 727
LEU A 580
 None
 1.12A 6ew0B-1e4oA:
4.9		 6ew0B-1e4oA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 707
LEU A 703
ALA A 587
LEU A 727
LEU A 580
 None
 1.12A 6ew0D-1e4oA:
5.0		 6ew0D-1e4oA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 707
LEU A 703
ALA A 587
LEU A 727
LEU A 580
 None
 1.12A 6ew0H-1e4oA:
4.0		 6ew0H-1e4oA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A 707
LEU A 703
ALA A 587
LEU A 727
LEU A 580
 None
 1.11A 6ew0I-1e4oA:
5.0		 6ew0I-1e4oA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ALA A 572
TYR A 613
GLN A 531
ILE A 530
 None
PLP  A 999 ( 4.7A)
None
None
 1.21A 6f6sA-1e4oA:
0.0
6f6sB-1e4oA:
0.0		 6f6sA-1e4oA:
8.74
6f6sB-1e4oA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 ALA A 332
SER A 337
GLY A 413
ILE A 371
 None
 0.76A 6f8cA-1e4oA:
0.0		 6f8cA-1e4oA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		7 / 12 GLY A 113
GLY A 114
ASP A 307
VAL A 420
ASN A 449
ARG A 534
GLY A 640
 GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.6A)
None
GLC  A 998 (-3.3A)
GLC  A 996 (-4.1A)
PLP  A 999 ( 3.2A)
 0.70A 6gneA-1e4oA:
24.0		 6gneA-1e4oA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLU A  67
GLY A 113
GLY A 114
ARG A 534
GLY A 642
 GLC  A 997 (-3.3A)
GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 996 (-4.1A)
PLP  A 999 (-3.4A)
 1.13A 6gneB-1e4oA:
23.8		 6gneB-1e4oA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		8 / 12 GLU A  67
GLY A 113
GLY A 114
ASP A 307
VAL A 420
ASN A 449
ARG A 534
GLY A 640
 GLC  A 997 (-3.3A)
GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.6A)
None
GLC  A 998 (-3.3A)
GLC  A 996 (-4.1A)
PLP  A 999 ( 3.2A)
 0.73A 6gneB-1e4oA:
23.8		 6gneB-1e4oA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		7 / 12 ASP A 259
ASP A 307
HIS A 309
ASN A 449
ARG A 534
GLU A 637
GLY A 640
 GLC  A 995 ( 4.4A)
GLC  A 997 (-3.6A)
GLC  A 996 (-4.0A)
GLC  A 998 (-3.3A)
GLC  A 996 (-4.1A)
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.80A 6gnfA-1e4oA:
24.1		 6gnfA-1e4oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 GLY A 113
GLY A 114
TYR A 256
HIS A 345
VAL A 420
 GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 996 (-3.8A)
GLC  A 998 (-4.3A)
None
 0.72A 6gnfA-1e4oA:
24.0		 6gnfA-1e4oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 10 GLY A 114
LEU A 115
TYR A 256
HIS A 345
VAL A 420
 PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-3.8A)
GLC  A 998 (-4.3A)
None
 0.66A 6gnfC-1e4oA:
23.9		 6gnfC-1e4oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		7 / 12 ASP A 259
ASP A 307
HIS A 309
ASN A 449
ARG A 534
GLU A 637
GLY A 640
 GLC  A 995 ( 4.4A)
GLC  A 997 (-3.6A)
GLC  A 996 (-4.0A)
GLC  A 998 (-3.3A)
GLC  A 996 (-4.1A)
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.83A 6gnfC-1e4oA:
23.9		 6gnfC-1e4oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLY A 113
LEU A 115
ASP A 307
HIS A 309
ASN A 449
 GLC  A 997 (-3.3A)
GLC  A 997 (-3.8A)
GLC  A 997 (-3.6A)
GLC  A 996 (-4.0A)
GLC  A 998 (-3.3A)
 0.59A 6gngA-1e4oA:
23.1		 6gngA-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		7 / 12 GLU A  67
GLY A 114
HIS A 345
VAL A 420
ARG A 534
GLU A 637
GLY A 640
 GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 998 (-4.3A)
None
GLC  A 996 (-4.1A)
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.74A 6gngA-1e4oA:
23.1		 6gngA-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		7 / 12 GLU A  67
GLY A 114
TYR A 256
HIS A 345
VAL A 420
GLU A 637
GLY A 640
 GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 996 (-3.8A)
GLC  A 998 (-4.3A)
None
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.78A 6gngA-1e4oA:
23.1		 6gngA-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 THR A 262
HIS A 367
PRO A 257
GLU A 194
GLY A 183
 None
 1.44A 6gngB-1e4oA:
23.3		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 TYR A 256
HIS A 345
VAL A 420
GLU A 637
GLY A 640
 GLC  A 996 (-3.8A)
GLC  A 998 (-4.3A)
None
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.77A 6gngB-1e4oA:
23.3		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		6 / 12 GLU A  67
GLY A 113
GLY A 114
LEU A 115
HIS A 309
ARG A 534
 GLC  A 997 (-3.3A)
GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
 0.65A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLU A  67
GLY A 114
LEU A 115
HIS A 309
ARG A 534
 GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
 1.07A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 ASP A 259
ASP A 307
ASN A 449
 GLC  A 995 ( 4.4A)
GLC  A 997 (-3.6A)
GLC  A 998 (-3.3A)
 0.64A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 SER A 729
ARG A 540
THR A 633
ALA A 742
 None
 1.08A 6ma6A-1e4oA:
0.0		 6ma6A-1e4oA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 ARG A 366
ALA A 332
THR A 336
ILE A 314
 None
 0.86A 6ma7A-1e4oA:
0.0		 6ma7A-1e4oA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1e4o MALTODEXTRIN
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 HIS A  60
ARG A 285
HIS A 288
ASP A 282
 None
 1.24A 6mn4C-1e4oA:
undetectable		 6mn4C-1e4oA:
17.87