SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 12 ILE A  26
ILE A   3
LEU A 107
ILE A 212
ILE A  20
 None
 0.88A 1oipA-1e4yA:
undetectable		 1oipA-1e4yA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 11 THR A 191
ALA A  93
ILE A  65
ALA A  99
ASP A  61
 None
 1.34A 2admB-1e4yA:
undetectable		 2admB-1e4yA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		4 / 8 ALA A  95
ALA A  99
ILE A  65
GLU A  62
 None
 0.85A 3dtuC-1e4yA:
0.0
3dtuD-1e4yA:
0.0		 3dtuC-1e4yA:
14.56
3dtuD-1e4yA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 10 GLY A  85
THR A  31
VAL A  64
ASP A  61
ILE A  65
 AP5  A 215 (-4.4A)
AP5  A 215 (-3.4A)
AP5  A 215 (-4.5A)
None
None
 1.04A 4jx1B-1e4yA:
undetectable		 4jx1B-1e4yA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		4 / 8 ARG A 156
ARG A 167
ASP A  84
ARG A  88
 AP5  A 215 (-2.8A)
AP5  A 215 (-2.8A)
AP5  A 215 ( 4.7A)
AP5  A 215 (-3.6A)
 1.41A 4kr4C-1e4yA:
0.0		 4kr4C-1e4yA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 10 ASP A  33
GLY A  14
SER A  30
GLY A  85
ASP A 159
 None
AP5  A 215 (-3.4A)
None
AP5  A 215 (-4.4A)
None
 1.20A 4mmcA-1e4yA:
undetectable		 4mmcA-1e4yA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 12 VAL A  64
SER A  30
GLY A  32
ASP A  84
LYS A  13
 AP5  A 215 (-4.5A)
None
AP5  A 215 (-3.1A)
AP5  A 215 ( 4.7A)
AP5  A 215 (-2.9A)
 1.42A 4pevC-1e4yA:
3.0		 4pevC-1e4yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 10 GLY A   7
ALA A  93
ILE A   4
LEU A   6
TYR A 182
 None
 1.16A 4xj7A-1e4yA:
2.9
4xj7B-1e4yA:
2.8		 4xj7A-1e4yA:
24.73
4xj7B-1e4yA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 12 VAL A  59
LEU A  58
ASP A 158
GLY A  56
LEU A   9
 AP5  A 215 (-3.7A)
AP5  A 215 (-4.1A)
None
AP5  A 215 ( 4.6A)
AP5  A 215 (-3.9A)
 1.08A 4y8wB-1e4yA:
0.0		 4y8wB-1e4yA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 7 GLY A  85
THR A  31
ASP A  61
ILE A  65
VAL A  64
 AP5  A 215 (-4.4A)
AP5  A 215 (-3.4A)
None
None
AP5  A 215 (-4.5A)
 1.37A 5ik1A-1e4yA:
0.0		 5ik1A-1e4yA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 7 GLY A  85
THR A  31
VAL A  64
ASP A  61
ILE A  65
 AP5  A 215 (-4.4A)
AP5  A 215 (-3.4A)
AP5  A 215 (-4.5A)
None
None
 1.09A 5ik1A-1e4yA:
0.0		 5ik1A-1e4yA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 7 GLY A  85
THR A  31
VAL A  64
ILE A  65
VAL A  68
 AP5  A 215 (-4.4A)
AP5  A 215 (-3.4A)
AP5  A 215 (-4.5A)
None
None
 1.36A 5ik1A-1e4yA:
0.0		 5ik1A-1e4yA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		4 / 7 ILE A 120
VAL A 121
ARG A 124
GLN A 160
 None
 1.31A 5kkzM-1e4yA:
0.0
5kkzO-1e4yA:
undetectable		 5kkzM-1e4yA:
21.98
5kkzO-1e4yA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 12 ASP A 159
THR A  60
ARG A 156
GLY A  32
LEU A  35
 None
None
AP5  A 215 (-2.8A)
AP5  A 215 (-3.1A)
None
 1.37A 5m50B-1e4yA:
2.1		 5m50B-1e4yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1e4y ADENYLATE KINASE
(Escherichia
coli) 		5 / 12 VAL A 196
PHE A 109
ALA A 194
LEU A 213
LEU A 209
 None
 1.01A 5x23A-1e4yA:
0.0		 5x23A-1e4yA:
17.80