SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		4 / 6 LEU A 155
LEU A 182
PRO A 167
VAL A 193
 None
 1.20A 2dqyC-1e51A:
0.9		 2dqyC-1e51A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		4 / 8 LEU A 249
ARG A 243
PRO A 167
MET A 170
 None
 1.20A 2qd2A-1e51A:
0.8		 2qd2A-1e51A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		5 / 9 PHE A 200
ALA A 198
ALA A 230
GLY A 229
GLY A 232
 None
 1.28A 2v7bB-1e51A:
undetectable		 2v7bB-1e51A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		5 / 10 VAL A  37
PHE A  36
ILE A  32
LEU A 108
LEU A  61
 None
 1.05A 3gwxA-1e51A:
0.0		 3gwxA-1e51A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		5 / 11 VAL A  58
LEU A  61
ILE A  78
GLY A  80
ALA A 101
 None
 1.15A 3n8yA-1e51A:
undetectable		 3n8yA-1e51A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		5 / 12 LEU A  61
PHE A  79
ILE A 314
LEU A  73
TYR A 196
 None
 1.15A 3sp9A-1e51A:
0.0		 3sp9A-1e51A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		5 / 12 LEU A  61
PHE A  79
ILE A 314
LEU A  73
TYR A 196
 None
 1.15A 3sp9B-1e51A:
0.0		 3sp9B-1e51A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		4 / 8 PRO A  51
VAL A  53
PRO A  34
GLN A 322
 None
 0.97A 4iilA-1e51A:
2.4		 4iilA-1e51A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		4 / 7 GLN A 322
THR A 320
LEU A  31
THR A  24
 None
 1.14A 4mbsA-1e51A:
undetectable		 4mbsA-1e51A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		3 / 3 PRO A  67
LEU A  68
GLN A 325
 None
 0.60A 4pevB-1e51A:
undetectable		 4pevB-1e51A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		3 / 3 ARG A 174
ASP A 169
TYR A 196
 None
 0.89A 4yo9B-1e51A:
0.0		 4yo9B-1e51A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		3 / 3 ILE A 178
MET A 250
ASP A 169
 None
 0.75A 5h2uA-1e51A:
undetectable		 5h2uA-1e51A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens) 		5 / 12 ILE A  32
VAL A  53
LEU A  65
GLY A  52
PRO A  51
 None
 1.17A 5ienA-1e51A:
undetectable		 5ienA-1e51A:
16.01