SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 5 THR A  22
LEU A  94
GLY A  96
LYS A  99
 VO3  A1001 (-4.4A)
None
None
VO3  A1001 (-2.9A)
 1.33A 1gtiF-1e59A:
0.0		 1gtiF-1e59A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		5 / 12 ASP A 195
TYR A 193
LEU A   7
LEU A   5
MET A 172
 None
 1.48A 1p33C-1e59A:
undetectable		 1p33C-1e59A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		5 / 12 ALA A  62
GLY A  23
SER A  57
LEU A  86
SER A 186
 None
VO3  A1001 (-3.6A)
None
None
None
 1.00A 3gyqA-1e59A:
undetectable
3gyqB-1e59A:
undetectable		 3gyqA-1e59A:
21.99
3gyqB-1e59A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		3 / 3 SER A  30
SER A  13
HIS A  64
 None
VO3  A1001 ( 4.1A)
None
 0.76A 3mzeA-1e59A:
0.0		 3mzeA-1e59A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 4 ILE A 168
VAL A   6
VAL A 178
ARG A 171
 None
 1.10A 4m6tA-1e59A:
undetectable		 4m6tA-1e59A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 8 LEU A   7
VAL A  69
LEU A  66
ILE A 179
 None
 0.87A 4r38D-1e59A:
0.0		 4r38D-1e59A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 6 TYR A  49
GLU A 216
TYR A 227
LEU A 213
 None
 1.15A 4twdB-1e59A:
0.0
4twdC-1e59A:
0.0		 4twdB-1e59A:
22.46
4twdC-1e59A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 7 GLU A 216
TYR A 227
LEU A 213
TYR A  49
 None
 1.20A 4twdF-1e59A:
0.0
4twdJ-1e59A:
0.0		 4twdF-1e59A:
22.46
4twdJ-1e59A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		3 / 3 MET A 197
GLU A 201
LEU A 205
 None
 0.80A 4v2oB-1e59A:
0.0		 4v2oB-1e59A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 7 GLY A  92
GLN A  95
TYR A 132
HIS A  90
 None
 1.04A 4ws0A-1e59A:
undetectable		 4ws0A-1e59A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 5 LEU A 190
ALA A 182
VAL A 178
ILE A 179
 None
 0.89A 4xe3A-1e59A:
0.0		 4xe3A-1e59A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 5 LEU A 190
ALA A 182
VAL A 178
ILE A 179
 None
 0.80A 4xe3B-1e59A:
0.0		 4xe3B-1e59A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1e59 PHOSPHOGLYCERATE
MUTASE
(Escherichia
coli) 		4 / 8 ILE A 179
THR A   3
VAL A   2
GLU A 216
 None
 1.02A 6fbvC-1e59A:
undetectable		 6fbvC-1e59A:
12.13