SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 GLY A  49
ASN A  45
GLY A  44
PHE A  47
MET A 234
 None
 1.29A 1ffyA-1e5fA:
undetectable		 1ffyA-1e5fA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 11 ASN A 158
ARG A 373
GLY A 112
THR A 114
GLY A  86
 SO4  A 407 ( 3.5A)
SO4  A 407 (-2.9A)
None
None
PLP  A 405 (-3.1A)
 1.26A 1jr1A-1e5fA:
undetectable		 1jr1A-1e5fA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 8 TYR A 210
GLY A 377
GLY A 341
GLY A 340
SER A 310
 None
 1.31A 1qzzA-1e5fA:
undetectable		 1qzzA-1e5fA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 10 ILE A 232
ARG A 233
LEU A 229
TYR A 152
THR A 186
 None
GOL  A 412 (-4.0A)
None
None
PLP  A 405 (-3.8A)
 1.40A 1tdrB-1e5fA:
undetectable		 1tdrB-1e5fA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 9 LEU A 229
ILE A 240
ILE A  90
VAL A  81
ILE A 232
 None
 1.12A 2avoA-1e5fA:
undetectable		 2avoA-1e5fA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		3 / 3 GLN A 176
LYS A 149
VAL A 151
 None
 0.76A 2jfaB-1e5fA:
0.0		 2jfaB-1e5fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ILE A 132
GLU A 108
HIS A 115
ALA A  91
LEU A  98
 None
 1.34A 2xkwB-1e5fA:
0.0		 2xkwB-1e5fA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 ALA A 275
ALA A 157
PRO A 156
THR A 160
LEU A 374
 None
 1.00A 2zifB-1e5fA:
undetectable		 2zifB-1e5fA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 8 THR A 186
GLY A  86
ALA A  89
THR A  93
ILE A 182
 PLP  A 405 (-3.8A)
PLP  A 405 (-3.1A)
None
None
None
 1.43A 3jusB-1e5fA:
undetectable		 3jusB-1e5fA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 9 THR A 186
GLY A  86
ALA A  89
THR A  93
ILE A 182
 PLP  A 405 (-3.8A)
PLP  A 405 (-3.1A)
None
None
None
 1.43A 3jusB-1e5fA:
0.0		 3jusB-1e5fA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 VAL A 202
VAL A  81
LEU A 229
GLY A  88
ALA A  89
 None
 1.30A 3pghA-1e5fA:
0.0		 3pghA-1e5fA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 6 GLY A  86
VAL A 218
SER A  85
THR A 208
 PLP  A 405 (-3.1A)
PLP  A 405 ( 4.6A)
PLP  A 405 (-3.7A)
PLP  A 405 (-3.5A)
 1.09A 3tj7A-1e5fA:
0.0
3tj7B-1e5fA:
0.0		 3tj7A-1e5fA:
18.09
3tj7B-1e5fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 6 GLY A  86
VAL A 218
SER A  85
THR A 208
 PLP  A 405 (-3.1A)
PLP  A 405 ( 4.6A)
PLP  A 405 (-3.7A)
PLP  A 405 (-3.5A)
 1.07A 3tj7C-1e5fA:
0.0
3tj7D-1e5fA:
0.0		 3tj7C-1e5fA:
18.09
3tj7D-1e5fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 6 VAL A 218
SER A  85
THR A 208
GLY A  86
 PLP  A 405 ( 4.6A)
PLP  A 405 (-3.7A)
PLP  A 405 (-3.5A)
PLP  A 405 (-3.1A)
 1.07A 3tj7C-1e5fA:
0.0
3tj7D-1e5fA:
0.0		 3tj7C-1e5fA:
18.09
3tj7D-1e5fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 11 LEU A 278
LEU A 392
ILE A 372
LEU A 327
ILE A 333
 None
 1.11A 3tqbA-1e5fA:
undetectable		 3tqbA-1e5fA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 9 ALA A 350
PRO A 349
ILE A 367
GLY A 112
VAL A 357
 None
 1.46A 4a3uA-1e5fA:
undetectable		 4a3uA-1e5fA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 PHE A 292
PRO A 156
ILE A 192
SER A 268
MET A 272
 None
 1.17A 4a83A-1e5fA:
1.0		 4a83A-1e5fA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 7 PHE A 131
VAL A 129
ILE A 127
GLU A 361
 None
 1.09A 4a97H-1e5fA:
0.0		 4a97H-1e5fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		3 / 3 GLU A 267
GLY A 341
SER A 310
 None
 0.63A 4b53B-1e5fA:
undetectable		 4b53B-1e5fA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 10 ALA A 121
LEU A 117
PHE A 118
ALA A  89
THR A  93
 None
 1.06A 4j14A-1e5fA:
0.0		 4j14A-1e5fA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 7 LEU A 345
VAL A 337
GLU A 343
TYR A 210
 None
SO4  A 407 (-4.1A)
None
None
 0.99A 4lb2A-1e5fA:
0.0		 4lb2A-1e5fA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 11 ILE A 232
ARG A 233
LEU A 229
TYR A 152
THR A 186
 None
GOL  A 412 (-4.0A)
None
None
PLP  A 405 (-3.8A)
 1.25A 4qi9C-1e5fA:
undetectable		 4qi9C-1e5fA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 4 ASN A 185
VAL A 200
THR A 155
ILE A 164
 None
 1.50A 4retA-1e5fA:
0.0		 4retA-1e5fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 4 ASN A 185
VAL A 200
THR A 155
ILE A 164
 None
 1.50A 4retC-1e5fA:
2.1		 4retC-1e5fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 SER A 268
LEU A 161
THR A 313
ALA A 275
TYR A 210
 None
 1.50A 5dsgB-1e5fA:
0.0		 5dsgB-1e5fA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 11 LEU A 229
ILE A 240
ILE A  90
VAL A  81
ILE A 232
 None
 1.24A 5kr2B-1e5fA:
undetectable		 5kr2B-1e5fA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 11 LEU A 257
GLY A 256
GLY A 213
LEU A  74
THR A 259
 None
 1.02A 5o96G-1e5fA:
undetectable		 5o96G-1e5fA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 PHE A 131
PHE A 118
THR A 123
ALA A 183
THR A 155
 None
 1.29A 5vcgA-1e5fA:
undetectable		 5vcgA-1e5fA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 8 ALA A 157
THR A 160
THR A 313
ALA A 350
 None
 0.98A 5x2tI-1e5fA:
undetectable
5x2tJ-1e5fA:
undetectable
5x2tK-1e5fA:
undetectable
5x2tL-1e5fA:
undetectable		 5x2tI-1e5fA:
17.13
5x2tJ-1e5fA:
13.76
5x2tK-1e5fA:
17.13
5x2tL-1e5fA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		4 / 5 HIS A 354
GLU A 361
LEU A 122
VAL A 129
 None
 1.21A 6bc9A-1e5fA:
undetectable		 6bc9A-1e5fA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		5 / 12 LEU A 229
ILE A 240
ILE A  90
VAL A  81
ILE A 232
 None
 1.18A 6difA-1e5fA:
undetectable		 6difA-1e5fA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1e5f METHIONINE
GAMMA-LYASE
(Trichomonas
vaginalis) 		3 / 3 ARG A  46
PHE A  47
GLY A  43
 None
 0.71A 6fgdA-1e5fA:
0.0		 6fgdA-1e5fA:
23.50