SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 177
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.22A 1d1gA-1e5mA:
undetectable		 1d1gA-1e5mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.18A 1dhiA-1e5mA:
undetectable		 1dhiA-1e5mA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.18A 1dhjA-1e5mA:
undetectable		 1dhjA-1e5mA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.17A 1draA-1e5mA:
undetectable		 1draA-1e5mA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.19A 1drbA-1e5mA:
undetectable		 1drbA-1e5mA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE A 287
GLY A 280
ASN A 314
GLY A 282
PHE A 401
 None
 1.38A 1ho5A-1e5mA:
undetectable		 1ho5A-1e5mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 9 GLY A 238
GLY A 109
ILE A 108
VAL A 355
ILE A 352
 None
 1.07A 1hxwA-1e5mA:
undetectable		 1hxwA-1e5mA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 170
THR A 165
SER A 239
ALA A 354
ILE A 174
 None
 1.00A 1nt2A-1e5mA:
0.3		 1nt2A-1e5mA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLU A 299
ALA A 325
LYS A 292
ALA A 290
 None
 1.11A 1sn0B-1e5mA:
0.0
1sn0D-1e5mA:
0.0		 1sn0B-1e5mA:
18.10
1sn0D-1e5mA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A 165
GLY A 347
GLY A 348
GLY A 193
HIS A 307
 None
 1.22A 1wg8A-1e5mA:
undetectable		 1wg8A-1e5mA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A  84
ILE A  17
ILE A 241
VAL A 355
LEU A  31
 None
 1.13A 1xozA-1e5mA:
undetectable		 1xozA-1e5mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 7 THR A 199
PRO A 200
GLY A 114
ASP A  75
 None
 0.82A 2ddwB-1e5mA:
undetectable		 2ddwB-1e5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.19A 2drcA-1e5mA:
undetectable		 2drcA-1e5mA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 11 THR A 267
THR A 409
ALA A 265
ARG A 281
GLY A 280
 None
 1.24A 2f162-1e5mA:
undetectable		 2f162-1e5mA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL A 316
ASN A 314
ALA A 283
GLN A 324
 None
 1.11A 2ij7C-1e5mA:
undetectable		 2ij7C-1e5mA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A 231
ARG A 230
ARG A 224
 None
 0.96A 2j9dA-1e5mA:
0.0
2j9dC-1e5mA:
0.0		 2j9dA-1e5mA:
13.79
2j9dC-1e5mA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A 242
ALA A 173
ILE A 108
GLY A 347
 None
 0.78A 2o4nB-1e5mA:
undetectable		 2o4nB-1e5mA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 4 SER A 337
GLY A 308
HIS A 221
ASP A 217
 None
 1.29A 2oxtC-1e5mA:
undetectable		 2oxtC-1e5mA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 10 LEU A 107
GLY A 105
GLY A 192
LEU A 244
ALA A 177
 None
 0.97A 2v3kA-1e5mA:
undetectable		 2v3kA-1e5mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  15
SER A  85
ALA A  84
SER A 349
GLY A 347
 None
 0.89A 2vmyA-1e5mA:
undetectable		 2vmyA-1e5mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 4 GLY A 192
GLY A 351
GLY A 348
GLY A 240
 None
 0.60A 3bogD-1e5mA:
0.0		 3bogD-1e5mA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLN A  87
ILE A  20
GLY A  21
GLY A  30
THR A  18
 None
 1.04A 3bwcA-1e5mA:
undetectable		 3bwcA-1e5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  20
GLY A  21
ASP A  59
GLY A  37
GLN A  29
 None
 0.87A 3bwcA-1e5mA:
undetectable		 3bwcA-1e5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  20
GLY A  21
ASP A  59
GLY A  37
GLN A  29
 None
 0.93A 3bwcB-1e5mA:
undetectable		 3bwcB-1e5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		3 / 3 CYH A  83
HIS A  79
PHE A  80
 None
 1.18A 3cr4X-1e5mA:
0.0		 3cr4X-1e5mA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 408
SER A 400
ASN A 399
ILE A 304
THR A 338
 None
 1.21A 3ddyA-1e5mA:
undetectable		 3ddyA-1e5mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.19A 3drcA-1e5mA:
undetectable		 3drcA-1e5mA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 9 LEU A  94
VAL A  11
GLY A 192
ILE A 108
ALA A 188
ILE A 243
 None
 1.25A 3el0B-1e5mA:
undetectable		 3el0B-1e5mA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 238
ALA A 196
THR A 110
GLU A 237
ILE A  17
 None
 1.18A 3id6C-1e5mA:
0.3		 3id6C-1e5mA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		3 / 3 SER A 337
GLY A 308
SER A 223
 None
 0.59A 3loqA-1e5mA:
undetectable		 3loqA-1e5mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 8 ILE A 352
SER A 171
GLY A 351
SER A 400
ASN A 305
 None
 1.32A 3lslA-1e5mA:
0.8
3lslD-1e5mA:
0.0		 3lslA-1e5mA:
20.96
3lslD-1e5mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 8 SER A 400
ASN A 305
ILE A 352
SER A 171
GLY A 351
 None
 1.34A 3lslA-1e5mA:
0.8
3lslD-1e5mA:
0.0		 3lslA-1e5mA:
20.96
3lslD-1e5mA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 211
PHE A 233
ILE A 112
LEU A 346
GLY A 205
 None
 1.07A 3rukB-1e5mA:
undetectable		 3rukB-1e5mA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
ILE A 104
 None
 1.35A 3tq9A-1e5mA:
undetectable		 3tq9A-1e5mA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 5 ARG A 389
LEU A 391
VAL A 366
ASP A 382
 None
 1.13A 3ufnA-1e5mA:
0.0
3ufnB-1e5mA:
0.0		 3ufnA-1e5mA:
12.14
3ufnB-1e5mA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 391
PRO A 367
VAL A 366
ASP A 382
 None
 1.06A 3ufnA-1e5mA:
0.0
3ufnB-1e5mA:
0.0		 3ufnA-1e5mA:
12.14
3ufnB-1e5mA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 244
ALA A 188
ALA A 255
ALA A  92
ILE A 257
 None
 1.20A 3ut5D-1e5mA:
undetectable		 3ut5D-1e5mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 147
VAL A 164
ILE A 243
ILE A 241
PHE A  77
 None
 0.96A 3w67B-1e5mA:
undetectable		 3w67B-1e5mA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 5 THR A 199
ILE A 198
GLU A  56
PHE A  80
 None
 1.41A 4acbC-1e5mA:
undetectable		 4acbC-1e5mA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  55
GLU A  56
GLY A  21
ASN A  22
GLU A 353
 None
 1.17A 4jlgA-1e5mA:
undetectable		 4jlgA-1e5mA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A  94
VAL A  95
LYS A 187
GLU A 245
 None
 0.97A 4lb2A-1e5mA:
undetectable		 4lb2A-1e5mA:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		10 / 12 GLY A 111
ALA A 166
CYH A 167
GLU A 195
PHE A 206
HIS A 307
THR A 309
HIS A 344
LEU A 346
GLY A 402
 None
 0.62A 4ls7A-1e5mA:
72.8		 4ls7A-1e5mA:
57.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		7 / 12 GLY A 111
ALA A 166
GLU A 195
PHE A 206
LEU A 346
GLY A 402
PHE A 403
 None
 0.87A 4ls7A-1e5mA:
72.8		 4ls7A-1e5mA:
57.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		8 / 12 GLY A 111
ALA A 166
GLU A 195
SER A 202
PHE A 206
THR A 309
HIS A 344
LEU A 346
 None
 0.67A 4ls7A-1e5mA:
72.8		 4ls7A-1e5mA:
57.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		8 / 12 ALA A 166
CYH A 167
PHE A 206
HIS A 307
THR A 309
HIS A 344
LEU A 346
GLY A 402
 None
 0.64A 4ls7A-1e5mA:
72.8
4ls7B-1e5mA:
72.3		 4ls7A-1e5mA:
57.75
4ls7B-1e5mA:
57.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 166
PHE A 206
LEU A 346
GLY A 402
PHE A 403
 None
 0.94A 4ls7A-1e5mA:
72.8
4ls7B-1e5mA:
72.3		 4ls7A-1e5mA:
57.75
4ls7B-1e5mA:
57.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 166
SER A 202
PHE A 206
THR A 309
HIS A 344
LEU A 346
 None
 0.68A 4ls7A-1e5mA:
72.8
4ls7B-1e5mA:
72.3		 4ls7A-1e5mA:
57.75
4ls7B-1e5mA:
57.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		7 / 12 ILE A 112
ALA A 166
CYH A 167
HIS A 307
THR A 309
HIS A 344
GLY A 402
 None
 0.82A 4ls7A-1e5mA:
72.8
4ls7B-1e5mA:
72.3		 4ls7A-1e5mA:
57.75
4ls7B-1e5mA:
57.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 112
ALA A 166
SER A 202
THR A 309
HIS A 344
 None
 0.99A 4ls7A-1e5mA:
72.8
4ls7B-1e5mA:
72.3		 4ls7A-1e5mA:
57.75
4ls7B-1e5mA:
57.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 348
GLY A 170
GLY A 350
LEU A 242
GLY A 192
 None
 0.83A 4o33A-1e5mA:
undetectable		 4o33A-1e5mA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 177
SER A  85
ILE A  89
LEU A  94
ARG A 253
 None
 1.30A 4qi9C-1e5mA:
undetectable		 4qi9C-1e5mA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 8 SER A 400
ALA A 354
SER A 398
ALA A 173
 None
 0.79A 4twdF-1e5mA:
0.0
4twdG-1e5mA:
0.0
4twdH-1e5mA:
0.0
4twdI-1e5mA:
0.0
4twdJ-1e5mA:
0.0		 4twdF-1e5mA:
20.41
4twdG-1e5mA:
20.41
4twdH-1e5mA:
20.41
4twdI-1e5mA:
20.41
4twdJ-1e5mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  89
SER A  85
THR A 163
ALA A 146
ASN A 160
 None
 1.08A 4u14A-1e5mA:
undetectable		 4u14A-1e5mA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A 111
THR A 110
GLY A 114
GLU A 195
 None
 1.16A 4v20A-1e5mA:
0.0		 4v20A-1e5mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 7 ILE A 108
CYH A 162
GLU A 195
GLY A 348
GLY A 193
 None
 1.49A 5a06A-1e5mA:
undetectable		 5a06A-1e5mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 7 ILE A 108
CYH A 162
GLU A 195
GLY A 348
GLY A 193
 None
 1.46A 5a06C-1e5mA:
undetectable		 5a06C-1e5mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 7 ILE A 108
CYH A 162
GLU A 195
GLY A 348
GLY A 193
 None
 1.50A 5a06E-1e5mA:
undetectable		 5a06E-1e5mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 7 ILE A 108
CYH A 162
GLU A 195
GLY A 348
GLY A 193
 None
 1.49A 5a06F-1e5mA:
undetectable		 5a06F-1e5mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 5 THR A 267
GLY A 282
GLU A 318
HIS A 307
 None
 1.22A 5c0oH-1e5mA:
undetectable		 5c0oH-1e5mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 345
THR A  18
ARG A  35
GLY A  37
ILE A  38
 None
 1.13A 5ifuA-1e5mA:
undetectable		 5ifuA-1e5mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 361
GLY A 259
GLU A 353
SER A 171
ILE A 174
 None
 1.21A 5igvA-1e5mA:
undetectable		 5igvA-1e5mA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 361
GLY A 259
GLU A 353
SER A 171
ILE A 174
 None
 1.20A 5igwA-1e5mA:
0.0		 5igwA-1e5mA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 8 THR A 342
SER A 337
SER A 336
ALA A 356
 None
 0.96A 5l5fY-1e5mA:
0.0
5l5fZ-1e5mA:
0.0		 5l5fY-1e5mA:
19.31
5l5fZ-1e5mA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  15
ILE A 241
TYR A 258
VAL A 358
LEU A 154
 None
 1.21A 5nz0A-1e5mA:
0.0		 5nz0A-1e5mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 8 GLY A 155
LEU A 154
VAL A  82
ILE A 190
GLY A 105
 None
 1.11A 5vkqB-1e5mA:
0.0
5vkqC-1e5mA:
0.0		 5vkqB-1e5mA:
12.72
5vkqC-1e5mA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 MET A 266
ALA A 168
GLY A 170
SER A 171
LEU A 410
 None
 1.40A 5vlmF-1e5mA:
0.0		 5vlmF-1e5mA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLN A  87
GLY A 351
ILE A 190
GLY A 193
GLY A 192
 None
 1.10A 5wyqA-1e5mA:
undetectable		 5wyqA-1e5mA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		4 / 7 LEU A 410
ALA A 168
THR A 165
THR A 163
 None
 0.78A 6a7jA-1e5mA:
undetectable		 6a7jA-1e5mA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		5 / 10 GLY A 347
GLY A 111
ALA A 169
HIS A 406
GLY A 402
 None
 1.01A 6e5zA-1e5mA:
undetectable		 6e5zA-1e5mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II
(Synechocystis
sp.
PCC
6803) 		3 / 3 LEU A  14
ASN A 305
LEU A  31
 None
 0.75A 6exiD-1e5mA:
undetectable		 6exiD-1e5mA:
14.78