SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_A_CCSA417_0 (ESTROGEN RECEPTOR)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	3 / 3	GLU A 269 LYS A 263 VAL A 265	None	0.93A	1l2iA-1e5rA: 0.0	1l2iA-1e5rA: 24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_A_AG2A7005_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	4 / 6	LEU A 23 ASP A 19 LEU A 16 ILE A 81	None	1.07A	1mt1A-1e5rA: 0.0 1mt1F-1e5rA: 0.0	1mt1A-1e5rA: 13.67 1mt1F-1e5rA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_B_AG2B7001_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	4 / 6	ILE A 81 LEU A 23 ASP A 19 LEU A 16	None	1.04A	1mt1B-1e5rA: 0.0 1mt1C-1e5rA: 0.0	1mt1B-1e5rA: 17.89 1mt1C-1e5rA: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2V_A_BZ1A302_2 (CARBONIC ANHYDRASE 2)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	3 / 3	HIS A 43 VAL A 82 LEU A 171	None	0.65A	4m2vA-1e5rA: 0.0	4m2vA-1e5rA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWR_A_ZMRA513_2 (NEURAMINIDASE)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	4 / 5	LEU A 281 ASP A 273 ARG A 272 ILE A 253	None	1.36A	4mwrA-1e5rA: undetectable	4mwrA-1e5rA: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MM4_B_TA1B501_1 (TUBULIN BETA CHAIN)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	5 / 10	VAL A 126 GLU A 128 HIS A 135 ALA A 133 SER A 130	None	1.07A	5mm4B-1e5rA: undetectable	5mm4B-1e5rA: 13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TRQ_B_ACTB307_0 (WELO5)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	3 / 3	GLU A 247 HIS A 238 VAL A 243	None	0.86A	5trqB-1e5rA: 9.3	5trqB-1e5rA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YVN_A_ACTA305_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	1e5r	PROLINE OXIDASE (Streptomyces sp. TH1)	4 / 6	LEU A 20 GLN A 169 LEU A 171 LEU A 78	None	1.17A	5yvnA-1e5rA: undetectable	5yvnA-1e5rA: 22.78

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L2I_A_CCSA417_0","ESTROGEN RECEPTOR","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",3,"GLU A 269;LYS A 263;VAL A 265","None","0.93A","1l2iA-1e5rA:0.0","1l2iA-1e5rA:24.21"],["1MT1_A_AG2A7005_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",4,"LEU A  23;ASP A  19;LEU A  16;ILE A  81","None","1.07A","1mt1A-1e5rA:0.0;1mt1F-1e5rA:0.0","1mt1A-1e5rA:13.67;1mt1F-1e5rA:17.89"],["1MT1_B_AG2B7001_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",4,"ILE A  81;LEU A  23;ASP A  19;LEU A  16","None","1.04A","1mt1B-1e5rA:0.0;1mt1C-1e5rA:0.0","1mt1B-1e5rA:17.89;1mt1C-1e5rA:13.67"],["4M2V_A_BZ1A302_2","CARBONIC ANHYDRASE 2","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",3,"HIS A  43;VAL A  82;LEU A 171","None","0.65A","4m2vA-1e5rA:0.0","4m2vA-1e5rA:20.51"],["4MWR_A_ZMRA513_2","NEURAMINIDASE","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",4,"LEU A 281;ASP A 273;ARG A 272;ILE A 253","None","1.36A","4mwrA-1e5rA:undetectable","4mwrA-1e5rA:20.10"],["5MM4_B_TA1B501_1","TUBULIN BETA CHAIN","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",5,"VAL A 126;GLU A 128;HIS A 135;ALA A 133;SER A 130","None","1.07A","5mm4B-1e5rA:undetectable","5mm4B-1e5rA:13.54"],["5TRQ_B_ACTB307_0","WELO5","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",3,"GLU A 247;HIS A 238;VAL A 243","None","0.86A","5trqB-1e5rA:9.3","5trqB-1e5rA:19.00"],["5YVN_A_ACTA305_0","GLUTATHIONE S-TRANSFERASE OMEGA-1","1e5r","PROLINE OXIDASE","Streptomyces sp. TH1",4,"LEU A  20;GLN A 169;LEU A 171;LEU A  78","None","1.17A","5yvnA-1e5rA:undetectable","5yvnA-1e5rA:22.78"]]