SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 1e5u INTIMIN
(Escherichia
coli) 		5 / 9 LEU I  20
ASP I   5
GLY I  58
ILE I  11
ILE I   9
 None
 1.13A 3s56B-1e5uI:
undetectable		 3s56B-1e5uI:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1e5u INTIMIN
(Escherichia
coli) 		4 / 7 LEU I  62
ASP I  54
ILE I   4
THR I  68
 None
 0.93A 4eyrA-1e5uI:
0.0		 4eyrA-1e5uI:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1e5u INTIMIN
(Escherichia
coli) 		4 / 7 LYS I  63
SER I  45
VAL I  53
TRP I  43
 None
 1.38A 4l64A-1e5uI:
undetectable		 4l64A-1e5uI:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1e5u INTIMIN
(Escherichia
coli) 		4 / 8 TYR I 163
GLU I 123
THR I 184
ASN I 120
 None
 1.21A 6c71B-1e5uI:
undetectable		 6c71B-1e5uI:
19.46