SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1e5w MOESIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 0.98A 1fduA-1e5wA:
undetectable		 1fduA-1e5wA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1e5w MOESIN
(Homo
sapiens) 		5 / 12 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 0.95A 1fduC-1e5wA:
undetectable		 1fduC-1e5wA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1e5w MOESIN
(Homo
sapiens) 		5 / 11 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.10A 1iolA-1e5wA:
undetectable		 1iolA-1e5wA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1e5w MOESIN
(Homo
sapiens) 		5 / 12 ILE A 245
ILE A 257
ASP A 221
VAL A 220
LEU A 218
 None
 1.01A 1qhyA-1e5wA:
undetectable		 1qhyA-1e5wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1e5w MOESIN
(Homo
sapiens) 		4 / 8 PHE A  44
GLY A  46
THR A  11
PHE A  80
 None
 1.08A 1ykiC-1e5wA:
0.0
1ykiD-1e5wA:
0.0		 1ykiC-1e5wA:
22.86
1ykiD-1e5wA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1e5w MOESIN
(Homo
sapiens) 		3 / 3 GLN A 131
HIS A 176
ARG A 180
 None
 0.98A 1zlqA-1e5wA:
0.0		 1zlqA-1e5wA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1e5w MOESIN
(Homo
sapiens) 		5 / 9 THR A 121
ALA A 122
LEU A 124
ALA A 126
SER A 127
 None
 1.41A 3kp6B-1e5wA:
0.0		 3kp6B-1e5wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1e5w MOESIN
(Homo
sapiens) 		3 / 3 ASP A 266
ARG A 246
LYS A 258
 None
 1.27A 3wipG-1e5wA:
undetectable		 3wipG-1e5wA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 1e5w MOESIN
(Homo
sapiens) 		4 / 5 GLU A  92
SER A  90
ARG A 294
PRO A  86
 None
 1.14A 4k17B-1e5wA:
9.5		 4k17B-1e5wA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1e5w MOESIN
(Homo
sapiens) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.24A 5dzkb-1e5wA:
undetectable
5dzkp-1e5wA:
undetectable		 5dzkb-1e5wA:
21.01
5dzkp-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1e5w MOESIN
(Homo
sapiens) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.26A 5dzkc-1e5wA:
undetectable
5dzkq-1e5wA:
undetectable		 5dzkc-1e5wA:
21.01
5dzkq-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1e5w MOESIN
(Homo
sapiens) 		4 / 7 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.14A 5dzkD-1e5wA:
undetectable
5dzkR-1e5wA:
undetectable		 5dzkD-1e5wA:
21.01
5dzkR-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1e5w MOESIN
(Homo
sapiens) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.11A 5dzkf-1e5wA:
undetectable
5dzkt-1e5wA:
undetectable		 5dzkf-1e5wA:
21.01
5dzkt-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1e5w MOESIN
(Homo
sapiens) 		4 / 6 SER A 127
ALA A 126
HIS A 179
LEU A 124
 None
 1.25A 5dzkg-1e5wA:
undetectable
5dzku-1e5wA:
undetectable		 5dzkg-1e5wA:
21.01
5dzku-1e5wA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1e5w MOESIN
(Homo
sapiens) 		3 / 3 LYS A 254
LEU A 218
ILE A 248
 None
 0.78A 5kc0A-1e5wA:
0.3		 5kc0A-1e5wA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1e5w MOESIN
(Homo
sapiens) 		4 / 7 ARG A  81
PHE A  78
LEU A  29
SER A   6
 None
 1.15A 5uxcA-1e5wA:
0.0		 5uxcA-1e5wA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1e5w MOESIN
(Homo
sapiens) 		3 / 3 TYR A 201
ASP A 197
GLN A 196
 None
 0.80A 6g1pA-1e5wA:
0.0		 6g1pA-1e5wA:
22.22