SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A1147
ILE A1134
THR A1135
ILE A1132
VAL A1133
 None
 1.13A 1pkvA-1e69A:
0.0
1pkvB-1e69A:
undetectable		 1pkvA-1e69A:
15.77
1pkvB-1e69A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 11 ILE A1132
VAL A1133
LEU A1147
ILE A1134
THR A1135
 None
 1.13A 1pkvA-1e69A:
0.0
1pkvB-1e69A:
0.0		 1pkvA-1e69A:
15.77
1pkvB-1e69A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ASP A  42
GLY A  49
ASP A 129
THR A 124
 None
 1.04A 2aouA-1e69A:
undetectable		 2aouA-1e69A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A  41
LEU A   8
ILE A  20
LEU A   3
ILE A  44
 None
 0.97A 3cd2A-1e69A:
undetectable		 3cd2A-1e69A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 LEU A1089
LEU A1103
SER A1126
ASN A1125
 None
 1.05A 3lm8A-1e69A:
undetectable
3lm8C-1e69A:
undetectable		 3lm8A-1e69A:
23.53
3lm8C-1e69A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 LEU A1089
LEU A1103
SER A1126
ASN A1125
 None
 1.03A 3lm8B-1e69A:
undetectable
3lm8D-1e69A:
undetectable		 3lm8B-1e69A:
23.53
3lm8D-1e69A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A1089
LEU A1103
SER A1126
ASN A1125
 None
 1.02A 3lm8A-1e69A:
undetectable
3lm8C-1e69A:
undetectable		 3lm8A-1e69A:
23.53
3lm8C-1e69A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A1089
LEU A1103
SER A1126
ASN A1125
 None
 1.02A 3lm8B-1e69A:
undetectable
3lm8D-1e69A:
undetectable		 3lm8B-1e69A:
23.53
3lm8D-1e69A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.95A 3lzsA-1e69A:
undetectable		 3lzsA-1e69A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.95A 3lzsB-1e69A:
undetectable		 3lzsB-1e69A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 1.00A 3oxwA-1e69A:
undetectable		 3oxwA-1e69A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.98A 3oxwC-1e69A:
undetectable		 3oxwC-1e69A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 4 PRO A  17
LEU A  19
HIS A1148
LEU A1147
 None
 1.25A 3vw7A-1e69A:
0.0		 3vw7A-1e69A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A1092
ILE A1061
ALA A1087
PHE A1030
 None
 0.92A 4dc3B-1e69A:
undetectable		 4dc3B-1e69A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A   6
VAL A  93
ILE A 117
GLY A  49
VAL A  80
 None
 0.92A 4dqbA-1e69A:
undetectable		 4dqbA-1e69A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.95A 4dqbB-1e69A:
undetectable		 4dqbB-1e69A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.91A 4dqeB-1e69A:
undetectable		 4dqeB-1e69A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.94A 4dqhB-1e69A:
undetectable		 4dqhB-1e69A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 VAL A  93
LEU A 126
ASN A 103
VAL A 128
 None
 1.08A 4e1gB-1e69A:
0.2		 4e1gB-1e69A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A1100
ILE A1132
ASP A1145
PHE A  22
ALA A1143
 None
 1.20A 4eb4A-1e69A:
0.0		 4eb4A-1e69A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A1100
ILE A1132
ASP A1145
PHE A  22
ALA A1143
 None
 1.22A 4eb4B-1e69A:
0.0		 4eb4B-1e69A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A1110
TYR A1113
LEU A1083
GLU A1080
 None
 1.18A 4f3tA-1e69A:
undetectable		 4f3tA-1e69A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.96A 4hlaB-1e69A:
undetectable		 4hlaB-1e69A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A1036
ARG A1117
ALA A1143
GLU A1124
LEU A1083
 None
 1.39A 4la0A-1e69A:
undetectable		 4la0A-1e69A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 7 GLU A1105
ILE A  29
LEU A  82
ILE A  41
 None
 0.79A 4xumA-1e69A:
1.4		 4xumA-1e69A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 8 ILE A 139
LEU A1037
ILE A1034
LEU A1103
 None
 0.97A 5ieoA-1e69A:
0.2		 5ieoA-1e69A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A1110
TYR A1113
LEU A1083
GLU A1080
 None
 1.23A 5weaA-1e69A:
undetectable		 5weaA-1e69A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 10 PHE A1100
ILE A1132
ASP A1145
PHE A  22
ALA A1143
 None
 1.28A 5x66D-1e69A:
undetectable		 5x66D-1e69A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.93A 6dgxA-1e69A:
undetectable		 6dgxA-1e69A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A1092
GLY A1085
ALA A1087
GLY A1043
VAL A1026
 None
 0.98A 6dh0A-1e69A:
undetectable		 6dh0A-1e69A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A1096
SER A1098
SER A 132
 None
 1.06A 6gbfA-1e69A:
undetectable		 6gbfA-1e69A:
22.63