SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 ALA A 146
LEU A 192
ALA A 167
PHE A 144
ILE A 106
 None
 1.27A 1g5yB-1e6bA:
undetectable		 1g5yB-1e6bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 147
ALA A 159
LEU A 150
THR A 160
 None
None
None
BME  A 389 ( 4.9A)
 1.04A 1ictB-1e6bA:
undetectable		 1ictB-1e6bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 GLY A 177
GLN A 174
PHE A 144
ILE A 111
 None
 1.01A 2qmzA-1e6bA:
undetectable
2qmzB-1e6bA:
undetectable		 2qmzA-1e6bA:
22.05
2qmzB-1e6bA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 147
ALA A 159
LEU A 150
THR A 160
 None
None
None
BME  A 389 ( 4.9A)
 0.95A 3cfqA-1e6bA:
undetectable		 3cfqA-1e6bA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 147
ALA A 159
LEU A 150
THR A 160
 None
None
None
BME  A 389 ( 4.9A)
 0.99A 3cfqA-1e6bA:
undetectable
3cfqB-1e6bA:
undetectable		 3cfqA-1e6bA:
19.07
3cfqB-1e6bA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 147
ALA A 159
LEU A 150
THR A 160
 None
None
None
BME  A 389 ( 4.9A)
 1.00A 3d2tA-1e6bA:
undetectable		 3d2tA-1e6bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 ARG A  24
SER A  73
LEU A 209
PRO A 210
 None
 1.08A 3jq7B-1e6bA:
undetectable		 3jq7B-1e6bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 4 ALA A 172
HIS A  21
HIS A 176
PRO A 173
 None
 1.48A 3mbgA-1e6bA:
0.0		 3mbgA-1e6bA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 4 ALA A 172
HIS A  21
HIS A 176
PRO A 173
 None
 1.47A 3mbgC-1e6bA:
0.0		 3mbgC-1e6bA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		5 / 10 SER A  17
LEU A  41
PHE A  51
VAL A  39
ASN A  55
 None
 1.48A 3nuvB-1e6bA:
0.0		 3nuvB-1e6bA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		5 / 10 SER A  17
PHE A  51
VAL A  39
ASN A  55
ALA A  62
 None
 1.28A 3nuvB-1e6bA:
0.0		 3nuvB-1e6bA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 ASP A  45
GLY A  44
TYR A  14
PRO A  38
 None
 1.01A 3s3mA-1e6bA:
undetectable		 3s3mA-1e6bA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 ASP A  45
GLY A  44
TYR A  14
PRO A  38
 None
 1.00A 3s3nA-1e6bA:
undetectable		 3s3nA-1e6bA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 147
ALA A 159
LEU A 150
THR A 160
 None
None
None
BME  A 389 ( 4.9A)
 1.02A 4i89A-1e6bA:
undetectable		 4i89A-1e6bA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 147
ALA A 159
LEU A 150
THR A 160
 None
None
None
BME  A 389 ( 4.9A)
 1.03A 5bojA-1e6bA:
undetectable		 5bojA-1e6bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 4 CYH A 195
LEU A 151
LEU A 171
ALA A 103
 None
 1.07A 5hpuA-1e6bA:
undetectable
5hpuB-1e6bA:
undetectable		 5hpuA-1e6bA:
10.20
5hpuB-1e6bA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 1e6b GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 7 LEU A  80
TYR A  79
ASP A  67
LEU A  32
 None
 1.01A 5jq7B-1e6bA:
undetectable		 5jq7B-1e6bA:
19.11