SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 350
PRO A 351
VAL A 356
ASN A 407
 None
 0.56A 3u5kA-1e6iA:
16.0		 3u5kA-1e6iA:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 350
PRO A 351
VAL A 356
ASN A 407
 None
 0.52A 3u5kB-1e6iA:
16.1		 3u5kB-1e6iA:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 350
PRO A 351
VAL A 356
ASN A 407
 None
 0.57A 3u5kD-1e6iA:
16.2		 3u5kD-1e6iA:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 420
ALA A 396
PHE A 424
ASN A 401
 None
 1.47A 3uq6A-1e6iA:
undetectable		 3uq6A-1e6iA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 350
VAL A 356
TYR A 406
ASN A 407
 None
 0.64A 4lzrA-1e6iA:
15.9		 4lzrA-1e6iA:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		5 / 6 PRO A 351
VAL A 356
VAL A 361
TYR A 364
ASN A 407
 None
 0.47A 5pbeA-1e6iA:
17.6		 5pbeA-1e6iA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 343
LEU A 340
ILE A 339
ILE A 336
VAL A 399
 None
 0.73A 5uanB-1e6iA:
undetectable		 5uanB-1e6iA:
13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5
(Saccharomyces
cerevisiae) 		5 / 8 PRO A 351
VAL A 356
CYH A 403
TYR A 406
ASN A 407
 None
 0.65A 5y1yA-1e6iA:
16.0		 5y1yA-1e6iA:
34.40