SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 PHE A 399
THR A 397
ASP A 343
HIS A 398
 None
 0.98A 1ei6C-1e6vA:
undetectable		 1ei6C-1e6vA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 11 PRO C  25
ASN B 318
VAL C 116
TYR C 113
GLY C 115
 None
 1.30A 1fkpA-1e6vC:
0.8		 1fkpA-1e6vC:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 PRO A 342
ASN A  93
ASP A  87
TYR A  75
 None
 1.12A 1hpkA-1e6vA:
0.0		 1hpkA-1e6vA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ASP A 102
PHE A 523
MET A 316
LEU A 289
 None
 0.96A 1lhvA-1e6vA:
0.3		 1lhvA-1e6vA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 PHE C 147
TYR C 179
PRO C 149
 None
 1.14A 1mcnA-1e6vC:
undetectable
1mcnB-1e6vC:
0.0
1mcnP-1e6vC:
undetectable		 1mcnA-1e6vC:
18.75
1mcnB-1e6vC:
18.75
1mcnP-1e6vC:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.90A 1mt1G-1e6vA:
undetectable
1mt1J-1e6vA:
0.7		 1mt1G-1e6vA:
6.70
1mt1J-1e6vA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.91A 1mt1H-1e6vA:
0.4
1mt1K-1e6vA:
undetectable		 1mt1H-1e6vA:
11.53
1mt1K-1e6vA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.88A 1n13D-1e6vA:
0.3
1n13E-1e6vA:
undetectable		 1n13D-1e6vA:
11.53
1n13E-1e6vA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.87A 1n13A-1e6vA:
undetectable
1n13F-1e6vA:
0.4		 1n13A-1e6vA:
6.70
1n13F-1e6vA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.88A 1n13H-1e6vA:
0.4
1n13K-1e6vA:
undetectable		 1n13H-1e6vA:
11.53
1n13K-1e6vA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.88A 1n13G-1e6vA:
undetectable
1n13J-1e6vA:
0.5		 1n13G-1e6vA:
6.70
1n13J-1e6vA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.76A 1p7lD-1e6vB:
undetectable		 1p7lD-1e6vB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.74A 1p7lC-1e6vB:
undetectable		 1p7lC-1e6vB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 4 ALA B 314
VAL B 312
ALA B 313
HIS B 260
 None
 1.12A 1q23A-1e6vB:
1.0		 1q23A-1e6vB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 4 ALA B 314
VAL B 312
ALA B 313
HIS B 260
 None
 1.16A 1q23K-1e6vB:
0.9		 1q23K-1e6vB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.77A 1rg9B-1e6vB:
undetectable		 1rg9B-1e6vB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.74A 1rg9A-1e6vB:
undetectable		 1rg9A-1e6vB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.76A 1rg9D-1e6vB:
undetectable		 1rg9D-1e6vB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.76A 1rg9C-1e6vB:
undetectable		 1rg9C-1e6vB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 4 THR B 404
GLY C  79
ASP C 133
ALA B 321
 None
 1.11A 1sg9A-1e6vB:
undetectable		 1sg9A-1e6vB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 TYR C 190
SER C 152
VAL C 154
MET C  44
 None
 1.17A 1tv8A-1e6vC:
undetectable		 1tv8A-1e6vC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		3 / 3 TYR A 491
ARG C 245
GLN A 454
 None
 1.03A 1tw4A-1e6vA:
0.0		 1tw4A-1e6vA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 LEU B  58
ILE B 143
VAL B  80
LEU B  51
GLY B  53
 None
 0.92A 1uakA-1e6vB:
undetectable		 1uakA-1e6vB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 9 THR A 381
LEU A 385
GLY A 440
VAL C 238
ILE A 435
 None
 1.08A 2a1oB-1e6vA:
undetectable		 2a1oB-1e6vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 LEU B 113
LEU B  51
ILE B  54
ILE B 143
ALA B 142
 None
 0.99A 2bxqA-1e6vB:
1.0		 2bxqA-1e6vB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 TYR C 190
SER C 152
VAL C 154
MET C  44
 None
 1.12A 2fb2B-1e6vC:
undetectable		 2fb2B-1e6vC:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 TYR C 109
ARG C 105
VAL C 116
TYR C 113
 None
 1.02A 2fl5E-1e6vC:
undetectable
2fl5F-1e6vC:
undetectable		 2fl5E-1e6vC:
21.80
2fl5F-1e6vC:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 12 GLN A 434
LEU C 235
ASP A 375
VAL A 376
ALA A 409
 None
 1.39A 2g70A-1e6vA:
undetectable		 2g70A-1e6vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 LEU C 121
TYR A 447
GLY B 359
 None
 0.63A 2ocuA-1e6vC:
undetectable		 2ocuA-1e6vC:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 ASP A 181
ASP A 180
ILE A 179
ILE A 187
VAL A 210
 None
 0.90A 2q5kB-1e6vA:
undetectable		 2q5kB-1e6vA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 VAL B  80
ASP B  81
GLU B  55
 None
 0.69A 2qeuA-1e6vB:
1.4		 2qeuA-1e6vB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 VAL B  80
ASP B  81
GLU B  55
 None
 0.69A 2qeuC-1e6vB:
1.3		 2qeuC-1e6vB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 ASP B 229
ASN B 304
ASP A 466
ALA B 390
HIS B 385
 None
 1.48A 2qmjA-1e6vB:
undetectable		 2qmjA-1e6vB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.89A 2qqcD-1e6vA:
0.4
2qqcE-1e6vA:
undetectable		 2qqcD-1e6vA:
11.21
2qqcE-1e6vA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.91A 2qqcH-1e6vA:
0.4
2qqcK-1e6vA:
undetectable		 2qqcH-1e6vA:
11.21
2qqcK-1e6vA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 LEU A 537
ASP A  88
LEU A  89
GLY A  86
 None
 0.92A 2qqdB-1e6vA:
0.2
2qqdC-1e6vA:
0.1		 2qqdB-1e6vA:
11.53
2qqdC-1e6vA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 GLY B 327
THR B 331
PHE B 360
PHE B 376
 None
 1.16A 2qx4A-1e6vB:
undetectable
2qx4B-1e6vB:
undetectable		 2qx4A-1e6vB:
20.40
2qx4B-1e6vB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA A 235
ALA A 231
GLY A 111
CYH A 211
 None
 0.84A 2vh3B-1e6vA:
0.0		 2vh3B-1e6vA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 7 SER C 122
HIS C 160
HIS C 162
ARG A 404
 None
 1.43A 2vmyA-1e6vC:
undetectable
2vmyB-1e6vC:
undetectable		 2vmyA-1e6vC:
21.36
2vmyB-1e6vC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 10 ILE A 239
TYR A 135
LEU A 119
VAL A 118
LEU A 123
 None
 1.18A 2w98A-1e6vA:
undetectable		 2w98A-1e6vA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 8 ILE A 239
TYR A 135
LEU A 119
VAL A 118
LEU A 123
 None
 1.15A 2w98B-1e6vA:
undetectable		 2w98B-1e6vA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 5 TYR C 179
ARG C 155
ASP C 148
ASP C 210
 None
 1.49A 2yqzA-1e6vC:
undetectable		 2yqzA-1e6vC:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 5 TYR C 179
ARG C 155
ASP C 148
ASP C 210
 None
 1.50A 2yqzB-1e6vC:
undetectable		 2yqzB-1e6vC:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 4 GLU A  42
ARG A  39
ASN A  93
ASP A  88
 None
 1.03A 2zq9A-1e6vA:
0.0		 2zq9A-1e6vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 ASN A 279
GLY A 283
GLY A 267
TYR A 326
MET A 327
 None
 1.21A 2zw9A-1e6vA:
undetectable		 2zw9A-1e6vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		3 / 3 MET C  63
GLU B 410
ASN B 199
 None
 1.04A 3a27A-1e6vC:
undetectable		 3a27A-1e6vC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 10 GLU A 309
ARG A 529
ILE A 311
GLY A 314
LEU A 471
 None
 1.25A 3adsA-1e6vA:
0.6		 3adsA-1e6vA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 TYR B 242
ALA B 243
LEU B 247
ALA B 437
 None
 0.64A 3b6hA-1e6vB:
undetectable		 3b6hA-1e6vB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 TYR B 242
ALA B 243
LEU B 247
ALA B 437
 None
 0.71A 3b6hB-1e6vB:
undetectable		 3b6hB-1e6vB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 4 VAL C 116
ARG C 107
ILE C 146
THR B 265
 None
 1.24A 3cl9A-1e6vC:
undetectable		 3cl9A-1e6vC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 ALA C 106
GLN B 326
VAL C 116
ILE C  89
LEU C 134
 None
 0.97A 3datA-1e6vC:
undetectable		 3datA-1e6vC:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 ASN A 140
HIS A 141
VAL A 148
 None
None
F43  A1553 (-3.6A)
 0.85A 3elzB-1e6vA:
0.0		 3elzB-1e6vA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 5 ASN A 477
ARG B 384
ASN B 379
ALA A 272
 None
 1.27A 3frqA-1e6vA:
0.5		 3frqA-1e6vA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 7 ASN A 477
ARG B 384
ASN B 379
ALA A 272
 None
 1.28A 3frqB-1e6vA:
0.3		 3frqB-1e6vA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 ALA A 307
GLN A 496
ALA A 500
VAL A 380
LEU A 346
 None
 0.88A 3h0aA-1e6vA:
undetectable		 3h0aA-1e6vA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 PHE B 360
HIS B 377
THR B 383
VAL B 382
 None
 1.25A 3lb3A-1e6vB:
0.0		 3lb3A-1e6vB:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 PHE B 360
HIS B 377
THR B 383
VAL B 382
 None
 1.26A 3lb3B-1e6vB:
2.1		 3lb3B-1e6vB:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 11 THR A 420
ALA A 364
VAL A 357
ALA A 412
GLY A 413
 None
 0.91A 3mg0K-1e6vA:
0.0
3mg0L-1e6vA:
0.3		 3mg0K-1e6vA:
16.64
3mg0L-1e6vA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 ASP B 280
ILE B 256
VAL B 269
TYR B 335
 None
 1.05A 3p6hA-1e6vB:
undetectable		 3p6hA-1e6vB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 VAL C  74
LEU B 400
VAL B 253
GLY B 310
ALA B 313
 None
 1.11A 3pghA-1e6vC:
undetectable		 3pghA-1e6vC:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 THR A 295
ASP A 524
GLU A 519
 None
 0.78A 3qowA-1e6vA:
undetectable		 3qowA-1e6vA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 ILE B  79
LYS B 158
MET B 137
GLY B 136
 None
 1.21A 3sj0X-1e6vB:
undetectable		 3sj0X-1e6vB:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 GLN A 434
PHE A 446
GLY A 401
ALA A 405
GLY A 486
 None
TP7  A1554 (-4.2A)
None
None
None
 1.17A 3tegA-1e6vA:
4.1		 3tegA-1e6vA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 GLY A 429
GLY A 426
ILE A 494
ALA A 377
LEU A 436
 None
 1.13A 3uj7B-1e6vA:
undetectable		 3uj7B-1e6vA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 8 GLY B 163
GLY B 174
ILE B  54
LEU B  58
VAL B 140
 None
 1.40A 3v1nA-1e6vB:
undetectable		 3v1nA-1e6vB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 GLU C  75
LEU B 400
ARG C  71
ALA B 402
GLU C  65
 None
 1.44A 4cpzD-1e6vC:
undetectable		 4cpzD-1e6vC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 8 GLU A  19
GLU C 168
TYR A  25
ARG C 165
 None
 0.93A 4fgzA-1e6vA:
undetectable
4fgzB-1e6vA:
undetectable		 4fgzA-1e6vA:
16.36
4fgzB-1e6vA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 12 VAL C 238
ILE C 104
GLY A 440
GLY A 442
LEU C 235
 None
 1.05A 4iv0A-1e6vC:
undetectable		 4iv0A-1e6vC:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 10 THR A 381
LEU A 385
GLY A 440
VAL C 238
ILE A 435
 None
 0.91A 4jx1B-1e6vA:
undetectable		 4jx1B-1e6vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 GLU B 342
TRP C 111
LYS B 293
 None
 0.93A 4k7aA-1e6vB:
0.0		 4k7aA-1e6vB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.72A 4kttB-1e6vB:
0.0		 4kttB-1e6vB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.71A 4kttD-1e6vB:
0.0		 4kttD-1e6vB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 12 VAL C 238
ILE C 104
GLY A 440
GLY A 442
LEU C 235
 None
 1.04A 4mwzB-1e6vC:
undetectable		 4mwzB-1e6vC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.75A 4ndnB-1e6vB:
0.0		 4ndnB-1e6vB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.78A 4ndnD-1e6vB:
undetectable		 4ndnD-1e6vB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 VAL B  47
ALA B 177
PHE B 420
 None
 0.92A 4olbA-1e6vB:
0.0		 4olbA-1e6vB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 ILE A 169
GLY A 111
VAL A 263
HIS A 509
 None
 1.07A 4oltB-1e6vA:
0.0		 4oltB-1e6vA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 SER A 462
ASN A 459
LEU B 237
PHE B 350
GLY C 249
 None
 1.33A 4pevC-1e6vA:
0.1		 4pevC-1e6vA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 GLU C 230
TYR C 228
GLU A 386
GLU A 389
 None
 1.42A 4r87J-1e6vC:
0.0
4r87L-1e6vC:
0.0		 4r87J-1e6vC:
22.73
4r87L-1e6vC:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 VAL B 274
LEU B 237
LEU B 302
ALA B 305
THR B 343
 None
 1.07A 4x1kA-1e6vB:
undetectable
4x1kB-1e6vB:
undetectable		 4x1kA-1e6vB:
22.69
4x1kB-1e6vB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 12 GLY B 355
TYR A 449
SER B 329
ALA B 390
ASN B 336
 None
 1.37A 4ymgA-1e6vB:
0.0		 4ymgA-1e6vB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 12 GLY B 355
TYR A 449
SER B 329
ALA B 390
ASN B 336
 None
 1.35A 4ymgB-1e6vB:
undetectable		 4ymgB-1e6vB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 VAL B  47
ALA B 177
PHE B 420
 None
 0.91A 4z4iA-1e6vB:
undetectable		 4z4iA-1e6vB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 GLY A 475
PHE B 376
ILE B 375
GLY B 369
MET A 483
 None
None
None
TP7  A1554 ( 3.9A)
None
 1.20A 4zdyA-1e6vA:
0.0		 4zdyA-1e6vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 7 ARG B 384
ARG A 464
ASP B 229
TYR B 191
 None
 1.28A 5a06A-1e6vB:
undetectable		 5a06A-1e6vB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 7 ARG B 384
ARG A 464
ASP B 229
TYR B 191
 None
 1.27A 5a06D-1e6vB:
undetectable		 5a06D-1e6vB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 7 ARG B 384
ARG A 464
ASP B 229
TYR B 191
 None
 1.30A 5a06E-1e6vB:
undetectable		 5a06E-1e6vB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 5 PHE A 532
ASP A 524
PHE A 525
PHE A 523
 None
 1.13A 5a1rA-1e6vA:
0.0		 5a1rA-1e6vA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 5 TYR B 368
GLY A 332
TYR A 336
GLY A 486
 TP7  A1554 (-4.1A)
None
None
None
 1.05A 5ayfA-1e6vB:
undetectable		 5ayfA-1e6vB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 VAL B 257
LEU B 400
VAL B 213
THR B 209
 None
 1.03A 5e4dA-1e6vB:
2.2
5e4dB-1e6vB:
undetectable		 5e4dA-1e6vB:
19.25
5e4dB-1e6vB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 ALA B 396
THR B 209
VAL B 213
VAL B 257
 None
 1.01A 5eclA-1e6vB:
0.0		 5eclA-1e6vB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 GLY A 475
ILE B 375
GLY B 371
GLY B 369
MET A 483
 None
None
None
TP7  A1554 ( 3.9A)
None
 1.03A 5eqbA-1e6vA:
0.0		 5eqbA-1e6vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 VAL B 176
GLY B 163
PHE B 162
VAL B 149
CYH B 147
 None
 1.20A 5ergB-1e6vB:
undetectable		 5ergB-1e6vB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 GLY A 475
PHE B 376
ILE B 375
GLY B 369
MET A 483
 None
None
None
TP7  A1554 ( 3.9A)
None
 1.20A 5eslA-1e6vA:
0.0		 5eslA-1e6vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 THR A 295
ASP A 524
GLU A 519
 None
 0.74A 5fa8A-1e6vA:
0.0		 5fa8A-1e6vA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 5 GLY B 344
THR B 343
GLY A 384
LEU C 235
 None
 0.81A 5jlcA-1e6vB:
0.8		 5jlcA-1e6vB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 ALA A 246
VAL A 148
GLY A 146
ALA A 142
LEU A 143
 F43  A1553 (-3.6A)
F43  A1553 (-3.6A)
None
None
None
 1.06A 5jw1A-1e6vA:
0.0		 5jw1A-1e6vA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 ALA A 246
VAL A 148
GLY A 146
ALA A 142
LEU A 143
 F43  A1553 (-3.6A)
F43  A1553 (-3.6A)
None
None
None
 1.03A 5jw1B-1e6vA:
0.0		 5jw1B-1e6vA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		3 / 3 ARG B  15
PRO C  69
ASN B 208
 None
 0.83A 5jwaA-1e6vB:
0.0
5jwaH-1e6vB:
0.0		 5jwaA-1e6vB:
19.96
5jwaH-1e6vB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 PHE A 516
ILE A 512
ASN A 279
VAL A 108
ILE A 264
 None
 1.04A 5mlmA-1e6vA:
undetectable		 5mlmA-1e6vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 10 TYR B 334
TYR C 103
TYR C 109
THR C 118
ILE C 127
 None
 1.45A 5mvnD-1e6vB:
0.5		 5mvnD-1e6vB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 10 TYR C  22
ILE C 100
ILE C 104
THR C 218
ILE C 220
 None
 1.43A 5mzrA-1e6vC:
0.0		 5mzrA-1e6vC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 10 TYR C  22
ILE C 100
ILE C 104
THR C 218
ILE C 220
 None
 1.44A 5mzrC-1e6vC:
0.0		 5mzrC-1e6vC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 9 TYR C  22
ILE C 100
ILE C 104
THR C 218
ILE C 220
 None
 1.44A 5mzrD-1e6vC:
0.0		 5mzrD-1e6vC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 8 LEU B 333
TYR B 334
THR C 118
TYR A 447
 None
 1.22A 5ov9B-1e6vB:
undetectable		 5ov9B-1e6vB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 6 ARG C 155
HIS C 174
LEU C 171
SER C 152
 None
 1.49A 5syjB-1e6vC:
undetectable		 5syjB-1e6vC:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.75A 5t8sA-1e6vB:
undetectable		 5t8sA-1e6vB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 11 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
 None
 1.22A 5x6yA-1e6vB:
undetectable		 5x6yA-1e6vB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 11 VAL B 348
GLY B 347
GLU B 340
ALA B 353
LEU B 311
 None
 1.25A 5x6yC-1e6vB:
undetectable		 5x6yC-1e6vB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		4 / 6 LEU A 469
TYR B 191
ASP B 229
GLN B 221
 None
 1.32A 6djzC-1e6vA:
undetectable		 6djzC-1e6vA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		5 / 12 GLY A 475
PHE B 376
ILE B 375
GLY B 369
MET A 483
 None
None
None
TP7  A1554 ( 3.9A)
None
 1.21A 6e8qA-1e6vA:
undetectable		 6e8qA-1e6vA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		3 / 3 ALA B 305
PHE B 389
GLN B 221
 None
 0.76A 6eceA-1e6vB:
undetectable		 6eceA-1e6vB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 8 GLY B 131
GLN B 134
SER B 178
TYR B 165
 None
 1.14A 6eqpA-1e6vB:
undetectable		 6eqpA-1e6vB:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 ALA B 160
ASP B  78
ILE B  79
ILE B  86
 None
 0.82A 6fbnA-1e6vB:
0.0		 6fbnA-1e6vB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT
(Methanopyrus
kandleri) 		4 / 7 ARG C 107
LEU C 235
TYR C   9
VAL C 238
 None
 1.32A 6g2pA-1e6vC:
undetectable		 6g2pA-1e6vC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 PHE A 516
ILE A 512
ASN A 279
VAL A 108
ILE A 109
 None
 1.39A 6gsdA-1e6vA:
undetectable		 6gsdA-1e6vA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 PHE A 516
ILE A 512
ASN A 279
VAL A 108
ILE A 264
 None
 1.07A 6gsdA-1e6vA:
undetectable		 6gsdA-1e6vA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
(Methanopyrus
kandleri) 		5 / 12 VAL A 288
ILE A 512
ASN A 279
VAL A 108
ILE A 264
 None
 0.94A 6gsdA-1e6vA:
undetectable		 6gsdA-1e6vA:
10.85