SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e6w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 ARG A 252
ALA A 197
ALA A 157
GLU A 160
 None
 0.94A 1e7bA-1e6wA:
0.4		 1e7bA-1e6wA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 8 LEU A  39
LEU A  24
ALA A  27
LYS A  28
 None
 0.70A 1e7cA-1e6wA:
0.0		 1e7cA-1e6wA:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		7 / 11 GLY A  17
ALA A  19
SER A  20
ASP A  41
VAL A  65
ALA A  92
VAL A 120
 NAD  A 301 (-3.5A)
NAD  A 301 ( 4.0A)
NAD  A 301 (-2.7A)
NAD  A 301 (-2.7A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.6A)
NAD  A 301 (-4.2A)
 0.42A 1uayA-1e6wA:
36.0		 1uayA-1e6wA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		7 / 10 GLY A  17
ALA A  19
SER A  20
ASP A  41
VAL A  65
ALA A  92
VAL A 120
 NAD  A 301 (-3.5A)
NAD  A 301 ( 4.0A)
NAD  A 301 (-2.7A)
NAD  A 301 (-2.7A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.6A)
NAD  A 301 (-4.2A)
 0.45A 1uayB-1e6wA:
36.6		 1uayB-1e6wA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 10 ALA A  37
THR A  36
ALA A  35
ALA A  13
GLY A  55
 None
 0.92A 2f16K-1e6wA:
undetectable
2f16L-1e6wA:
undetectable		 2f16K-1e6wA:
24.25
2f16L-1e6wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 10 ALA A  37
THR A  36
ALA A  35
ALA A  13
GLY A  55
 None
 0.92A 2f16Y-1e6wA:
undetectable
2f16Z-1e6wA:
undetectable		 2f16Y-1e6wA:
24.25
2f16Z-1e6wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 ASN A  90
LEU A 205
TYR A 168
ALA A 197
SER A 155
 None
NAD  A 301 (-3.6A)
NAD  A 301 (-4.5A)
None
NAD  A 301 ( 3.9A)
 1.41A 2iyfB-1e6wA:
6.4		 2iyfB-1e6wA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 ARG A  29
GLY A  23
ILE A 151
VAL A  87
LEU A  30
 None
 1.18A 2zzmA-1e6wA:
6.6		 2zzmA-1e6wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 5 VAL A 135
VAL A 132
PHE A  82
ARG A 192
 None
 1.39A 3bjwB-1e6wA:
0.0		 3bjwB-1e6wA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 VAL A  14
ARG A 130
ILE A 191
THR A  16
 None
 1.41A 3cl9A-1e6wA:
1.4		 3cl9A-1e6wA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 4 LEU A  39
ASP A  86
VAL A  89
THR A  26
 None
 1.27A 3cyxB-1e6wA:
0.0		 3cyxB-1e6wA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 LEU A 253
SER A 155
THR A 153
VAL A  89
 None
NAD  A 301 ( 3.9A)
NAD  A 301 (-4.0A)
None
 0.85A 3d2tA-1e6wA:
0.0		 3d2tA-1e6wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 THR A 179
ILE A 182
ILE A 129
THR A 195
 None
 0.85A 3deuA-1e6wA:
0.0		 3deuA-1e6wA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		6 / 12 ASP A  86
VAL A 135
GLY A 137
ILE A 189
ILE A 182
ILE A 150
 None
 1.37A 3s54B-1e6wA:
undetectable		 3s54B-1e6wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 6 CYH A  58
THR A  36
ASN A  57
GLY A  55
 None
 1.20A 3w9tE-1e6wA:
0.0		 3w9tE-1e6wA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 ALA A  92
GLY A  21
GLY A  18
ILE A  15
 NAD  A 301 (-3.6A)
NAD  A 301 (-3.2A)
None
None
 0.67A 4eatA-1e6wA:
3.5		 4eatA-1e6wA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 SER A 155
GLN A 165
TYR A 168
LEU A 206
 NAD  A 301 ( 3.9A)
None
NAD  A 301 (-4.5A)
NAD  A 301 (-3.9A)
 0.57A 4hxyB-1e6wA:
19.7		 4hxyB-1e6wA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 ARG A 130
GLU A  68
ASN A 127
 None
 0.90A 4imaD-1e6wA:
2.4		 4imaD-1e6wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 ARG A 130
GLU A  68
ASN A 127
 None
 0.87A 4ip7D-1e6wA:
undetectable		 4ip7D-1e6wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 ASP A 142
ARG A 192
PRO A 244
 None
 0.91A 4wanC-1e6wA:
0.0		 4wanC-1e6wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 8 LEU A  24
GLY A  21
ALA A  27
LEU A  54
GLY A  47
 None
NAD  A 301 (-3.2A)
None
None
None
 0.97A 4zauA-1e6wA:
undetectable		 4zauA-1e6wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 ALA A  27
GLY A  17
GLY A  23
GLY A  21
LEU A  40
 None
NAD  A 301 (-3.5A)
None
NAD  A 301 (-3.2A)
None
 0.83A 5c0oH-1e6wA:
6.5		 5c0oH-1e6wA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 12 GLY A 148
ILE A 189
LEU A 186
GLY A 134
GLY A  83
 None
 1.10A 5d4uA-1e6wA:
6.9		 5d4uA-1e6wA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 9 ALA A  37
THR A  36
ALA A  35
ALA A  13
GLY A  55
 None
 0.95A 5l5zK-1e6wA:
undetectable
5l5zL-1e6wA:
undetectable		 5l5zK-1e6wA:
22.99
5l5zL-1e6wA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 9 ALA A  37
THR A  36
ALA A  35
ALA A  13
GLY A  55
 None
 0.95A 5l5zY-1e6wA:
undetectable
5l5zZ-1e6wA:
undetectable		 5l5zY-1e6wA:
22.99
5l5zZ-1e6wA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		3 / 3 ILE A 257
VAL A 221
PRO A 224
 None
 0.69A 5uunA-1e6wA:
0.9		 5uunA-1e6wA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 11 ALA A  37
THR A  36
ALA A  35
ALA A  13
GLY A  55
 None
 0.91A 6hwdK-1e6wA:
undetectable
6hwdL-1e6wA:
undetectable		 6hwdK-1e6wA:
16.73
6hwdL-1e6wA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e6w SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE
(Rattus
norvegicus) 		5 / 11 ALA A  37
THR A  36
ALA A  35
ALA A  13
GLY A  55
 None
 0.91A 6hwdY-1e6wA:
undetectable
6hwdZ-1e6wA:
undetectable		 6hwdY-1e6wA:
16.73
6hwdZ-1e6wA:
26.42