SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e6y'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 HIS C3157 HIS C3159 ARG A1421	None	1.33A	1eqbA-1e6yC: undetectable 1eqbB-1e6yC: undetectable	1eqbA-1e6yC: 20.15 1eqbB-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 SER C3160 HIS C3159 ARG A1421	None	1.12A	1eqbA-1e6yC: undetectable 1eqbB-1e6yC: undetectable	1eqbA-1e6yC: 20.15 1eqbB-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 HIS C3157 HIS C3159 ARG A1421	None	1.32A	1eqbA-1e6yC: undetectable 1eqbB-1e6yC: undetectable	1eqbA-1e6yC: 20.15 1eqbB-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 SER C3160 HIS C3159 ARG A1421	None	1.12A	1eqbA-1e6yC: undetectable 1eqbB-1e6yC: undetectable	1eqbA-1e6yC: 20.15 1eqbB-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 HIS C3157 HIS C3159 ARG A1421	None	1.33A	1eqbC-1e6yC: undetectable 1eqbD-1e6yC: undetectable	1eqbC-1e6yC: 20.15 1eqbD-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 SER C3160 HIS C3159 ARG A1421	None	1.12A	1eqbC-1e6yC: undetectable 1eqbD-1e6yC: undetectable	1eqbC-1e6yC: 20.15 1eqbD-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 HIS C3157 HIS C3159 ARG A1421	None	1.33A	1eqbC-1e6yC: undetectable 1eqbD-1e6yC: undetectable	1eqbC-1e6yC: 20.15 1eqbD-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	SER C3119 SER C3160 HIS C3159 ARG A1421	None	1.12A	1eqbC-1e6yC: undetectable 1eqbD-1e6yC: undetectable	1eqbC-1e6yC: 20.15 1eqbD-1e6yC: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHV_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	GLY A1324 GLY A1293 LEU A1295 GLY A1492	None	0.69A	1jhvA-1e6yA: undetectable	1jhvA-1e6yA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7F_A_BCZA801_0 (NEURAMINIDASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	LEU C3029 ASP C3145 ARG C3030 GLU C3208 GLU C3207	None	1.44A	1l7fA-1e6yC: undetectable	1l7fA-1e6yC: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7F_A_BCZA801_1 (NEURAMINIDASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	3 / 3	ARG C3152 ARG A1460 ARG C3176	None	0.97A	1l7fA-1e6yC: 0.0	1l7fA-1e6yC: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7G_A_BCZA801_0 (NEURAMINIDASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	LEU C3029 ASP C3145 ARG C3030 GLU C3208 GLU C3207	None	1.43A	1l7gA-1e6yC: undetectable	1l7gA-1e6yC: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7H_A_BCZA801_0 (NEURAMINIDASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	LEU C3029 ASP C3145 ARG C3030 GLU C3208 GLU C3207	None	1.43A	1l7hA-1e6yC: undetectable	1l7hA-1e6yC: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7H_A_BCZA801_1 (NEURAMINIDASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	3 / 3	ARG C3152 ARG A1460 ARG C3176	None	0.99A	1l7hA-1e6yC: undetectable	1l7hA-1e6yC: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_D_AG2D7015_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 7	LEU A1318 ARG A1546 ASP A1357 GLY A1090	None	0.88A	1n13D-1e6yA: undetectable 1n13E-1e6yA: undetectable	1n13D-1e6yA: 11.42 1n13E-1e6yA: 8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P7L_C_SAMC685_1 (S-ADENOSYLMETHIONINE SYNTHETASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.85A	1p7lD-1e6yB: undetectable	1p7lD-1e6yB: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P7L_C_SAMC885_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.86A	1p7lC-1e6yB: undetectable	1p7lC-1e6yB: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RBP_A_RTLA183_0 (PLASMA RETINOL-BINDING PROTEIN PRECURSOR)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	5 / 12	ALA B2305 PHE B2386 ALA B2304 GLN C3239 HIS B2233	None	1.37A	1rbpA-1e6yB: 0.0	1rbpA-1e6yB: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_A_SAMA385_1 (S-ADENOSYLMETHIONINE SYNTHETASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.84A	1rg9B-1e6yB: undetectable	1rg9B-1e6yB: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_B_SAMB485_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.84A	1rg9A-1e6yB: undetectable	1rg9A-1e6yB: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_C_SAMC585_1 (S-ADENOSYLMETHIONINE SYNTHETASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.84A	1rg9D-1e6yB: undetectable	1rg9D-1e6yB: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_C_SAMC685_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.86A	1rg9C-1e6yB: undetectable	1rg9C-1e6yB: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN5_C_T3C601_1 (TRANSTHYRETIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 6	LYS A1315 GLU A1319 ALA A1314 VAL A1431	None	1.11A	1sn5A-1e6yA: 0.0	1sn5A-1e6yA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQN_A_NDRA1001_0 (PROGESTERONE RECEPTOR)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	LEU A1123 LEU A1274 LEU A1150 MET A1154 TYR A1146	None GOL  A2574 (-4.2A) None None None	1.32A	1sqnA-1e6yA: undetectable	1sqnA-1e6yA: 18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T46_A_STIA3_2 (HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 7	VAL A1160 VAL A1149 TYR A1176 CYH A1175	F43  A2570 (-3.8A) None None None	1.12A	1t46A-1e6yA: undetectable	1t46A-1e6yA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TLS_B_C2FB266_0 (THYMIDYLATE SYNTHASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	SER A1307 ILE A1316 GLY A1518 VAL A1431 ALA A1432	None	1.14A	1tlsB-1e6yA: 0.0	1tlsB-1e6yA: 17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TUV_A_VK3A4558_1 (PROTEIN YGIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 7	TYR A1253 HIS A1127 LEU A1123 ILE A1245	None	1.13A	1tuvA-1e6yA: 3.2	1tuvA-1e6yA: 11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_1 (FATTY ACID-BINDING PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	3 / 3	TYR B2215 ARG B2041 GLN B2112	None	0.65A	1tw4A-1e6yB: 0.0	1tw4A-1e6yB: 13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_1 (FATTY ACID-BINDING PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	3 / 3	TYR A1508 ARG C3240 GLN A1471	None	0.95A	1tw4A-1e6yA: 0.0	1tw4A-1e6yA: 11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	6 / 12	LEU B2054 GLY B2052 ILE B2139 VAL B2076 LEU B2047 GLY B2049	None	1.25A	1uakA-1e6yB: undetectable	1uakA-1e6yB: 20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E5D_A_NCAA1501_0 (NICOTINAMIDE PHOSPHORIBOSYLTRANSF ERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 7	ARG C3177 ASP C3171 ALA C3191 ASP C3174	None	1.04A	2e5dA-1e6yC: 0.4 2e5dB-1e6yC: undetectable	2e5dA-1e6yC: 17.92 2e5dB-1e6yC: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E5D_B_NCAB1502_0 (NICOTINAMIDE PHOSPHORIBOSYLTRANSF ERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 7	ASP C3174 ARG C3177 ASP C3171 ALA C3191	None	1.03A	2e5dA-1e6yC: undetectable 2e5dB-1e6yC: undetectable	2e5dA-1e6yC: 17.92 2e5dB-1e6yC: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E7F_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	ILE B2420 LEU B2110 GLY B2414 SER B2410 ILE B2200	None	1.21A	2e7fA-1e6yB: undetectable	2e7fA-1e6yB: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E7F_B_C2FB4000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	ILE B2420 LEU B2110 GLY B2414 SER B2410 ILE B2200	None	1.17A	2e7fB-1e6yB: undetectable	2e7fB-1e6yB: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_A_GBNA2414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	GLY A1503 THR A1348 ALA A1349 ALA A1350	None	0.47A	2ej3A-1e6yA: undetectable	2ej3A-1e6yA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_C_GBNC1414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	GLY A1503 THR A1348 ALA A1349 ALA A1350	None	0.52A	2ej3C-1e6yA: undetectable	2ej3C-1e6yA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_H_BO2H1400_1 (PROTEASOME COMPONENT PUP1 PROTEASOME COMPONENT PUP3)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 11	SER A1434 ALA A1515 ALA A1394 GLY A1446 ASP A1488	None	1.11A	2f16H-1e6yA: undetectable 2f16I-1e6yA: undetectable	2f16H-1e6yA: 17.83 2f16I-1e6yA: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_V_BO2V1401_1 (PROTEASOME COMPONENT PUP1 PROTEASOME COMPONENT PUP3)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 11	SER A1434 ALA A1515 ALA A1394 GLY A1446 ASP A1488	None	1.12A	2f16V-1e6yA: undetectable 2f16W-1e6yA: undetectable	2f16V-1e6yA: 17.83 2f16W-1e6yA: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_1 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 7	TYR A1498 GLY A1473 TYR A1495 ASP C3238	None SMC  A1472 ( 2.4A) None None	1.08A	2g72B-1e6yA: undetectable	2g72B-1e6yA: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GLU_B_SAMB302_0 (YCGJ)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	6 / 12	GLY A1322 GLY A1506 ALA A1347 THR A1348 ALA A1323 PHE A1549	None	1.27A	2gluB-1e6yA: undetectable	2gluB-1e6yA: 17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HA4_A_ACHA546_0 (ACETYLCHOLINESTERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 8	TYR C3216 TYR B2289 PHE B2291 GLY C3010	None	1.06A	2ha4A-1e6yC: undetectable	2ha4A-1e6yC: 18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNJ_A_225A501_1 (CYTOCHROME P450 2C8)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 10	ILE B2111 VAL B2086 ALA B2134 VAL B2172 ILE B2050	None	1.02A	2nnjA-1e6yB: 0.7	2nnjA-1e6yB: 20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_B_SAMB201_1 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 5	ALA C3045 ASP C3036 ASP C3199 ASP C3195	None	1.04A	2nyuB-1e6yC: undetectable	2nyuB-1e6yC: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2O7O_A_DXTA222_1 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	ARG A1546 PRO A1545 VAL A1304 ILE A1316 SER A1310	None	1.30A	2o7oA-1e6yA: undetectable	2o7oA-1e6yA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OGY_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	ILE B2420 LEU B2110 GLY B2414 SER B2410 ILE B2200	None	1.21A	2ogyA-1e6yB: undetectable	2ogyA-1e6yB: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OGY_B_C2FB4000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	ILE B2420 LEU B2110 GLY B2414 SER B2410 ILE B2200	None	1.18A	2ogyB-1e6yB: undetectable	2ogyB-1e6yB: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PYN_A_1UNA1001_3 (PROTEASE RETROPEPSIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	3 / 3	ASP A1033 THR A1084 PRO A1085	None	0.63A	2pynB-1e6yA: undetectable	2pynB-1e6yA: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QAK_A_1UNA1001_4 (PROTEASE RETROPEPSIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	3 / 3	ASP A1033 THR A1084 PRO A1085	None	0.67A	2qakB-1e6yA: undetectable	2qakB-1e6yA: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5Q_B_1UNB900_1 (PROTEASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 9	LEU B2249 GLY B2263 ILE B2262 VAL B2253 ILE B2252	None	0.92A	2r5qA-1e6yB: undetectable	2r5qA-1e6yB: 15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5Q_D_1UND900_1 (PROTEASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 9	LEU B2249 GLY B2263 ILE B2262 VAL B2253 ILE B2252	None	0.92A	2r5qC-1e6yB: undetectable	2r5qC-1e6yB: 15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TRT_A_TACA222_1 (TETRACYCLINE REPRESSOR CLASS D)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 11	ARG A1546 PRO A1545 VAL A1304 ILE A1316 SER A1310	None	1.39A	2trtA-1e6yA: 0.9	2trtA-1e6yA: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V57_A_PRLA1188_0 (TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	SER B2177 ASN B2181 ILE B2178 ASP B2166	None	1.04A	2v57A-1e6yB: 0.0	2v57A-1e6yB: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V57_C_PRLC1187_0 (TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	SER B2177 ASN B2181 ILE B2178 ASP B2166	None	1.03A	2v57C-1e6yB: 0.0	2v57C-1e6yB: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VDM_B_AGGB1462_1 (INTEGRIN ALPHA-IIB INTEGRIN BETA-3)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	LEU C3163 SER C3013 ARG C3018 ASN C3017 ALA C3210	None	1.38A	2vdmA-1e6yC: 0.0 2vdmB-1e6yC: undetectable	2vdmA-1e6yC: 19.91 2vdmB-1e6yC: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VKE_A_TACA222_1 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 11	ARG A1546 PRO A1545 VAL A1304 ILE A1316 SER A1310	None	1.39A	2vkeA-1e6yA: 1.5	2vkeA-1e6yA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_A_GLYA502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 7	SER C3119 HIS C3157 HIS C3159 ARG A1421	None	1.33A	2vmyA-1e6yC: undetectable 2vmyB-1e6yC: undetectable	2vmyA-1e6yC: 19.95 2vmyB-1e6yC: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_B_GLYB502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	5 / 8	SER C3119 HIS C3157 SER C3160 HIS C3159 ARG A1421	None	1.36A	2vmyA-1e6yC: undetectable 2vmyB-1e6yC: undetectable	2vmyA-1e6yC: 19.95 2vmyB-1e6yC: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W8Y_B_NDRB1000_0 (PROGESTERONE RECEPTOR)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	LEU A1123 LEU A1274 LEU A1150 MET A1154 TYR A1146	None GOL  A2574 (-4.2A) None None None	1.31A	2w8yB-1e6yA: undetectable	2w8yB-1e6yA: 18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2I_B_QPSB1060_1 (ALPHA-1,4-GLUCAN LYASE ISOZYME 1)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 10	THR B2401 SER B2326 ASN B2315 ALA B2322 GLN B2402	None	1.44A	2x2iB-1e6yB: 0.0	2x2iB-1e6yB: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	3 / 3	ARG A1230 GLU A1548 SER A1229	None	0.92A	2xkkA-1e6yA: 2.7 2xkkC-1e6yA: 2.7	2xkkA-1e6yA: 20.38 2xkkC-1e6yA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XPW_A_OTCA222_1 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	ARG A1546 PRO A1545 VAL A1304 ILE A1316 SER A1310	None	1.35A	2xpwA-1e6yA: undetectable	2xpwA-1e6yA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRZ_A_ACTA1470_0 (DEOXYRIBODIPYRIMIDIN E PHOTOLYASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 5	ARG A1308 ALA A1534 ASP A1535 GLU A1201	None	1.10A	2xrzA-1e6yA: 0.0	2xrzA-1e6yA: 22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZQ9_A_CLSA11_1 (BETA-LACTAMASE TOHO-1)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 4	GLU A1051 ARG A1048 ASN A1104 ASP A1099	None	1.09A	2zq9A-1e6yA: 0.1	2zq9A-1e6yA: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZW9_A_SAMA801_0 (LEUCINE CARBOXYL METHYLTRANSFERASE 2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	ASN A1290 GLY A1294 GLY A1278 TYR A1336 MET A1337	None None None None AGM  A1285 (-3.9A)	1.23A	2zw9A-1e6yA: undetectable	2zw9A-1e6yA: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A27_A_SAMA250_1 (UNCHARACTERIZED PROTEIN MJ1557)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	3 / 3	MET C3060 GLU B2407 ASN B2195	None	0.99A	3a27A-1e6yC: undetectable	3a27A-1e6yC: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A35_A_RBFA191_1 (LUMAZINE PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	VAL A1094 THR A1087 ASP A1414 ASN A1024 ILE A1083	None	1.04A	3a35A-1e6yA: 0.0	3a35A-1e6yA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A35_B_RBFB191_1 (LUMAZINE PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	VAL A1094 THR A1087 ASP A1414 ASN A1024 ILE A1083	None	1.03A	3a35B-1e6yA: 0.0	3a35B-1e6yA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A3B_A_RBFA191_1 (LUMAZINE PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	VAL A1094 THR A1087 ASP A1414 ASN A1024 ILE A1083	None	1.01A	3a3bA-1e6yA: 0.0	3a3bA-1e6yA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AOB_C_RFPC2002_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	MET A1451 ALA A1428 PHE A1466 ARG A1421 GLY A1401	None	1.10A	3aobC-1e6yA: 3.9	3aobC-1e6yA: 19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BPX_A_SALA257_1 (TRANSCRIPTIONAL REGULATOR)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	SER B2212 ALA B2387 THR B2380 THR B2353	None	0.97A	3bpxA-1e6yB: 0.0 3bpxB-1e6yB: 0.0	3bpxA-1e6yB: 15.94 3bpxB-1e6yB: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D41_A_FCNA4001_1 (FOMA PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	GLY B2170 GLY B2169 GLY B2061 THR B2164	None	0.69A	3d41A-1e6yB: undetectable	3d41A-1e6yB: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D90_A_NOGA1001_1 (PROGESTERONE RECEPTOR)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	LEU A1123 LEU A1274 LEU A1150 MET A1154 TYR A1146	None GOL  A2574 (-4.2A) None None None	1.36A	3d90A-1e6yA: undetectable	3d90A-1e6yA: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCJ_B_THHB401_0 (PROBABLE 5'-PHOSPHORIBOSYLGLY CINAMIDE FORMYLTRANSFERASE PURN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	SER A1517 ILE A1511 THR A1360 GLY A1443	None	0.82A	3dcjB-1e6yA: undetectable	3dcjB-1e6yA: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DDY_A_RBFA187_1 (LUMAZINE PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	VAL A1094 THR A1087 ASP A1414 ASN A1024 ILE A1083	None	1.10A	3ddyA-1e6yA: undetectable	3ddyA-1e6yA: 16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	3 / 3	ASN A1151 HIS A1152 VAL A1159	None None F43  A2570 (-3.7A)	0.90A	3elzB-1e6yA: undetectable	3elzB-1e6yA: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FHX_B_PXLB313_1 (PYRIDOXAL KINASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	SER B2113 VAL B2043 THR B2129 VAL B2172	None	1.14A	3fhxB-1e6yB: undetectable	3fhxB-1e6yB: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_A_ERYA195_1 (REPRESSOR PROTEIN MPHR(A))	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 5	ASN A1494 ARG B2381 ASN B2376 ALA A1283	AGM  A1285 ( 3.7A) None None None	1.13A	3frqA-1e6yA: 0.5	3frqA-1e6yA: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_B_ERYB195_1 (REPRESSOR PROTEIN MPHR(A))	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri; Methanosarcina barkeri)	4 / 7	ASN A1494 ARG B2381 ASN B2376 ALA A1283	AGM  A1285 ( 3.7A) None None None	1.15A	3frqB-1e6yA: 0.4	3frqB-1e6yA: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FSU_A_C2FA995_0 (5,10-METHYLENETETRAH YDROFOLATE REDUCTASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	5 / 12	THR B2328 LEU B2397 SER C3066 ASN C3070 LEU B2313	None None OCS  C3065 ( 4.1A) None None	1.41A	3fsuA-1e6yB: undetectable	3fsuA-1e6yB: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FXR_A_ASCA3001_0 (LYSR TYPE REGULATOR OF TSAMBCD)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	ALA A1082 ILE A1083 ASN A1024 PRO A1097	None	0.91A	3fxrA-1e6yA: 0.0	3fxrA-1e6yA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GVU_A_STIA1001_2 (TYROSINE-PROTEIN KINASE ABL2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 5	VAL A1364 ILE A1393 TYR A1452 MET A1451	None	1.12A	3gvuA-1e6yA: undetectable	3gvuA-1e6yA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H0A_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	6 / 12	ALA B2205 ALA B2393 LEU B2397 ALA B2396 VAL B2265 ILE B2262	OCS  C3065 ( 3.6A) None None None None None	1.44A	3h0aA-1e6yB: undetectable	3h0aA-1e6yB: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_B_SAMB401_0 (O-METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	LEU A1356 GLY A1506 GLY A1507 SER A1296 ALA A1317	None	0.96A	3i5uB-1e6yA: undetectable	3i5uB-1e6yA: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MG0_V_BO2V1401_1 (PROTEASOME COMPONENT PUP1 PROTEASOME COMPONENT PUP3)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 11	SER A1434 ALA A1515 ALA A1394 GLY A1446 ASP A1488	None	1.11A	3mg0V-1e6yA: undetectable 3mg0W-1e6yA: undetectable	3mg0V-1e6yA: 17.83 3mg0W-1e6yA: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MNO_A_DEXA784_1 (GLUCOCORTICOID RECEPTOR)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	GLY C3150 VAL C3040 LEU C3037 THR C3141 ILE C3143	None	1.30A	3mnoA-1e6yC: undetectable	3mnoA-1e6yC: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MNP_A_DEXA784_1 (GLUCOCORTICOID RECEPTOR)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	GLY C3150 VAL C3040 LEU C3037 THR C3141 ILE C3143	None	1.33A	3mnpA-1e6yC: undetectable	3mnpA-1e6yC: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Z_B_FLPB1701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	ARG C3111 LEU C3057 LEU B2397 GLY B2317 ALA B2318	None	1.03A	3n8zB-1e6yC: undetectable	3n8zB-1e6yC: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PS9_A_SAMA670_0 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri; Methanosarcina barkeri)	5 / 12	GLY B2344 ASN B2301 LYS B2338 ILE C3236 GLY B2348	None None None None SMC  A1472 ( 4.9A)	1.22A	3ps9A-1e6yB: 2.0	3ps9A-1e6yB: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QX3_A_EVPA1_1 (DNA TOPOISOMERASE 2-BETA)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 5	GLY A1234 ASP A1233 ARG A1287 GLN A1109	None	1.28A	3qx3A-1e6yA: 1.6	3qx3A-1e6yA: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_B_SAMB300_0 (PUTATIVE METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	ARG B2384 GLY B2385 GLN B2234 SER B2209 ALA B2305	None	1.26A	3t7sB-1e6yB: undetectable	3t7sB-1e6yB: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7S_D_SAMD300_0 (PUTATIVE METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	ARG B2384 GLY B2385 GLN B2234 SER B2209 ALA B2305	None	1.27A	3t7sD-1e6yB: undetectable	3t7sD-1e6yB: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_B_SAMB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	GLY A1446 GLY A1443 ILE A1511 ALA A1394 LEU A1453	None	1.22A	3uj7B-1e6yA: undetectable	3uj7B-1e6yA: 18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_A_SAMA501_0 (MNMC2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	GLY A1430 GLY A1446 LEU A1449 ALA A1514 LEU A1435	None	1.10A	3vywA-1e6yA: undetectable	3vywA-1e6yA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_A_SAMA501_1 (MNMC2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 6	HIS A1223 ASP A1535 ASN A1541 GLU A1544	None	1.33A	3vywA-1e6yA: undetectable	3vywA-1e6yA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_B_SAMB401_0 (MNMC2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	GLY A1430 GLY A1446 LEU A1449 ALA A1514 LEU A1435	None	1.13A	3vywB-1e6yA: undetectable	3vywB-1e6yA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_D_SAMD401_0 (MNMC2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	GLY A1430 GLY A1446 LEU A1449 ALA A1514 LEU A1435	None	1.07A	3vywD-1e6yA: undetectable	3vywD-1e6yA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZOS_A_0LIA1004_1 (EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 11	LEU A1327 GLY A1506 ILE A1303 VAL A1431 GLY A1322	None	1.07A	3zosA-1e6yA: 0.0 3zosB-1e6yA: 0.0	3zosA-1e6yA: 20.67 3zosB-1e6yA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZQT_A_30ZA1920_1 (ANDROGEN RECEPTOR)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 6	PRO A1292 GLY A1293 ASN A1494 LEU A1281	None None AGM  A1285 ( 3.7A) AGM  A1285 ( 3.8A)	0.81A	3zqtA-1e6yA: 0.0	3zqtA-1e6yA: 17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3A_A_TACA222_1 (TETRACYCLINE REPRESSOR PROTEIN CLASS D)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	ARG A1546 PRO A1545 VAL A1304 ILE A1316 SER A1310	None	1.37A	4b3aA-1e6yA: 0.0	4b3aA-1e6yA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_D_D16D301_1 (THYMIDYLATE SYNTHASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	SER A1307 ILE A1316 GLY A1518 VAL A1431 ALA A1432	None	1.15A	4foxD-1e6yA: 0.0	4foxD-1e6yA: 17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUB_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	3 / 3	TYR C3050 ARG C3082 HIS C3043	None	1.12A	4fubA-1e6yC: 0.0	4fubA-1e6yC: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_M_ACTM503_0 (RNA POLYMERASE 3D-POL)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 4	PHE B2417 HIS B2196 GLY B2174 ILE B2175	None	1.49A	4k50M-1e6yB: 1.3	4k50M-1e6yB: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KTT_C_SAMC404_1 (S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.89A	4kttD-1e6yB: 0.0	4kttD-1e6yB: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_D_MXMD606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	ILE A1355 LEU A1318 VAL A1431 ALA A1428 LEU A1425	None	1.46A	4m11D-1e6yA: 1.4	4m11D-1e6yA: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MI4_A_SPMA201_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 6	GLU B2255 GLU B2267 TYR C3003 GLU B2275	None	1.41A	4mi4A-1e6yB: 0.0	4mi4A-1e6yB: 16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMD_A_29EA603_1 (TRANSPORTER)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 10	ASP A1488 ALA A1474 GLY A1507 SER A1445 GLY A1446	None	1.35A	4mmdA-1e6yA: 2.4	4mmdA-1e6yA: 22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODO_B_FK5B203_2 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	3 / 3	ALA C3045 GLN C3189 GLY C3153	None	0.65A	4odoC-1e6yC: 0.0	4odoC-1e6yC: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P3R_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	3 / 3	ASP C3130 ARG C3082 THR C3074	None	0.89A	4p3rA-1e6yC: undetectable	4p3rA-1e6yC: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PB1_A_RBVA501_1 (NUPC FAMILY PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	GLY A1510 GLN A1513 ALA A1509 SER A1307 ILE A1316	None	1.35A	4pb1A-1e6yA: undetectable	4pb1A-1e6yA: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVN_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 11	SER B2212 GLN B2217 CYH B2392 GLY B2375 THR B2380	None	1.27A	4qvnH-1e6yB: 0.6 4qvnI-1e6yB: 0.9	4qvnH-1e6yB: 21.21 4qvnI-1e6yB: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RP9_A_ASCA501_0 (ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	GLN C3087 ASP C3090 ALA C3149 ILE C3086 PHE C3088	None	1.34A	4rp9A-1e6yC: 0.0	4rp9A-1e6yC: 18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RUJ_A_VDXA501_1 (VITAMIN D3 RECEPTOR A)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	VAL B2265 SER B2268 ILE B2252 ARG B2272 VAL C3071	None	1.40A	4rujA-1e6yB: 0.8	4rujA-1e6yB: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_A_377A402_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 9	ALA A1426 SER A1450 ALA A1422 ALA A1428 SER A1397	None	1.33A	4twdA-1e6yA: 2.8 4twdB-1e6yA: 2.8 4twdC-1e6yA: 2.7 4twdD-1e6yA: 2.8 4twdE-1e6yA: 2.7	4twdA-1e6yA: 18.85 4twdB-1e6yA: 18.85 4twdC-1e6yA: 18.85 4twdD-1e6yA: 18.85 4twdE-1e6yA: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_A_377A402_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 9	ALA A1428 SER A1397 ALA A1426 SER A1450 ALA A1422	None	1.32A	4twdA-1e6yA: 2.8 4twdB-1e6yA: 2.8 4twdC-1e6yA: 2.7 4twdD-1e6yA: 2.8 4twdE-1e6yA: 2.7	4twdA-1e6yA: 18.85 4twdB-1e6yA: 18.85 4twdC-1e6yA: 18.85 4twdD-1e6yA: 18.85 4twdE-1e6yA: 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_B_AG2B505_1 (HOMOSPERMIDINE SYNTHASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 6	ARG C3129 ARG C3044 ASP C3049 ASP C3081	None	1.19A	4xqeB-1e6yC: undetectable	4xqeB-1e6yC: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YHA_A_MZMA303_1 (ALPHA-CARBONIC ANHYDRASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	5 / 12	HIS C3234 VAL C3233 VAL C3230 THR A1395 ALA A1394	None	1.36A	4yhaA-1e6yC: undetectable	4yhaA-1e6yC: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_A_SVRA205_1 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 7	TYR A1448 TYR A1452 LEU A1453 PHE C3223	None	0.99A	4yv5A-1e6yA: 0.0	4yv5A-1e6yA: 11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_D_SORD1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 6	GLU B2407 GLY B2411 GLY B2414 ASP B2415	None	0.95A	5a06D-1e6yB: undetectable	5a06D-1e6yB: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ALC_L_TIQL1210_2 (ANTI-TICAGRELOR FAB 72, LIGHT CHAIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	TYR A1328 GLY A1324 ILE A1316 GLY A1510	None	0.84A	5alcL-1e6yA: undetectable	5alcL-1e6yA: 17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 5	TYR B2365 GLY A1342 TYR A1346 GLY A1503	TP7  A2571 (-3.9A) None None None	1.06A	5ayfA-1e6yB: undetectable	5ayfA-1e6yB: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_C_ACTC403_0 (D-ALANINE--D-ALANINE LIGASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 4	TYR A1498 GLY A1446 SER A1445 LEU A1444	None	1.46A	5bphC-1e6yA: undetectable	5bphC-1e6yA: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C6P_A_4YHA601_1 (PROTEIN C)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	4 / 6	ALA B2210 SER B2209 SER C3066 ASP B2009	None None OCS  C3065 ( 4.1A) None	1.09A	5c6pA-1e6yB: 0.0	5c6pA-1e6yB: 23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CU6_A_ACTA403_0 (CASEIN KINASE II SUBUNIT ALPHA)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 6	TYR B2292 ILE B2278 VAL B2270 ALA B2273	None	0.83A	5cu6A-1e6yB: undetectable	5cu6A-1e6yB: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWZ_D_010D6_0 (N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE PEDV MAIN PROTEASE)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	3 / 3	MET A1451 HIS A1504 GLY A1462	None	0.80A	5gwzB-1e6yA: 0.0	5gwzB-1e6yA: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KR1_B_017B101_1 (PROTEASE PR5-DRV)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 10	LEU B2249 GLY B2263 ILE B2262 VAL B2253 ILE B2252	None	0.99A	5kr1A-1e6yB: undetectable	5kr1A-1e6yB: 14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	SER A1434 ALA A1429 ASP A1363 SER A1397	None	1.10A	5l5fY-1e6yA: 0.0 5l5fZ-1e6yA: 0.0	5l5fY-1e6yA: 18.52 5l5fZ-1e6yA: 17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	GLN B2112 ALA B2132 GLY B2131 ALA B2127 THR B2129	None	1.34A	5l5zH-1e6yB: 0.7 5l5zI-1e6yB: 0.9	5l5zH-1e6yB: 21.21 5l5zI-1e6yB: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	GLN B2112 ALA B2132 GLY B2131 ALA B2127 THR B2129	None	1.37A	5l5zV-1e6yB: 0.7 5l5zW-1e6yB: 0.8	5l5zV-1e6yB: 21.21 5l5zW-1e6yB: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_A_SAMA501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 12	LEU B2309 THR B2308 ALA B2311 LEU B2313 LEU B2248	None	0.97A	5nfjA-1e6yB: undetectable	5nfjA-1e6yB: 17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_A_SAMA501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	LEU A1399 ALA A1394 ILE A1402 GLY A1401 THR A1360	None	0.85A	5nfjA-1e6yA: undetectable	5nfjA-1e6yA: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_C_SAMC501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	5 / 12	LEU A1399 ALA A1394 ILE A1402 GLY A1401 THR A1360	None	0.90A	5nfjC-1e6yA: undetectable	5nfjC-1e6yA: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NU7_A_RTLA201_0 (RETINOL-BINDING PROTEIN 4)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 8	ALA A1394 MET A1451 TYR A1448 GLN A1469	None	0.97A	5nu7A-1e6yA: 0.0	5nu7A-1e6yA: 16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NUM_A_Z80A201_1 (BETA-LACTOGLOBULIN)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 8	VAL B2153 ILE B2050 LEU B2054 ILE B2075 ILE B2082	None	0.91A	5numA-1e6yB: undetectable	5numA-1e6yB: 12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T8S_B_SAMB402_0 (S-ADENOSYLMETHIONINE SYNTHASE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ALA B2156 ASP B2074 ILE B2075 ILE B2082	None	0.89A	5t8sA-1e6yB: undetectable	5t8sA-1e6yB: 23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_A_CVIA301_1 (REGULATORY PROTEIN TETR)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 8	ARG B2384 VAL B2350 ASP B2346 TYR B2347	None	1.04A	5vlmA-1e6yB: 1.1	5vlmA-1e6yB: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWO_A_SREA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 9	ILE B2200 GLY B2174 PHE B2417 SER B2410 GLY B2414	None	1.34A	6awoA-1e6yB: 0.0	6awoA-1e6yB: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWQ_A_SREA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	5 / 9	ILE B2200 GLY B2174 PHE B2417 SER B2410 GLY B2414	None	1.35A	6awqA-1e6yB: 0.0	6awqA-1e6yB: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB303_1 (BIFUNCTIONAL PROTEIN FOLD)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 5	TYR A1328 GLN A1505 GLY A1234 ILE A1115	None	1.43A	6debB-1e6yA: undetectable	6debB-1e6yA: 9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWD_D_GLYD713_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT GAMMA (Methanosarcina barkeri)	3 / 3	ARG C3044 HIS C3043 ARG C3082	None	1.03A	6dwdD-1e6yC: 0.0	6dwdD-1e6yC: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECE_C_DVAC3010_0 (VLM2 DODECADEPSIPEPTIDE)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	3 / 3	ALA B2302 PHE B2386 GLN B2217	None	0.72A	6eceA-1e6yB: undetectable	6eceA-1e6yB: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FK2_A_SORA302_0 (GALECTIN-3)	1e6y	METHYL-COENZYME M REDUCTASE I BETA SUBUNIT (Methanosarcina barkeri)	4 / 4	ARG B2272 GLU B2255 GLU B2275 ARG B2271	None	1.23A	6fk2A-1e6yB: undetectable	6fk2A-1e6yB: 13.69