SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 11 CYH A 147
LEU A 290
SER A 221
LEU A 103
ILE A 243
 None
 1.35A 1ee2A-1e7sA:
5.1		 1ee2A-1e7sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 11 CYH A 147
LEU A 290
SER A 221
LEU A 103
ILE A 243
 None
 1.39A 1ee2B-1e7sA:
undetectable		 1ee2B-1e7sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 224
LEU A 290
LEU A 285
HIS A 242
TYR A 111
 None
 1.34A 1kw0A-1e7sA:
undetectable		 1kw0A-1e7sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 224
LEU A 290
LEU A 285
HIS A 242
TYR A 111
 None
 1.47A 1mmkA-1e7sA:
undetectable		 1mmkA-1e7sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  41
HIS A  48
ILE A  91
ILE A  86
TYR A  81
 NAP  A1317 (-3.8A)
None
None
None
None
 1.47A 1ot7B-1e7sA:
0.0		 1ot7B-1e7sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 7 TYR A 309
GLN A 316
PHE A 173
ARG A 186
 None
 1.46A 2qmqA-1e7sA:
1.3		 2qmqA-1e7sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 246
GLY A 248
LEU A 290
ALA A 220
LEU A 212
 None
 0.94A 2yqzA-1e7sA:
undetectable		 2yqzA-1e7sA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 246
GLY A 248
LEU A 290
ALA A 220
LEU A 212
 None
 0.94A 2yqzB-1e7sA:
4.6		 2yqzB-1e7sA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 4 ARG A   5
ASP A  57
LEU A  23
ARG A  34
 None
 1.46A 2ziaB-1e7sA:
3.1		 2ziaB-1e7sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 5 LEU A 301
GLN A 258
LEU A 256
GLU A 255
 None
 0.82A 3h5gA-1e7sA:
undetectable
3h5gB-1e7sA:
undetectable		 3h5gA-1e7sA:
6.31
3h5gB-1e7sA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 8 TRP A 311
ILE A 260
VAL A 263
GLY A 304
 TRS  A1321 (-4.5A)
None
None
None
 0.83A 3hjoB-1e7sA:
0.1		 3hjoB-1e7sA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 245
LEU A 290
LEU A 212
ALA A 219
SER A 221
 None
 1.06A 3nt1A-1e7sA:
undetectable		 3nt1A-1e7sA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 245
LEU A 290
LEU A 212
ALA A 219
SER A 221
 None
 1.06A 3nt1B-1e7sA:
0.0		 3nt1B-1e7sA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 9 ARG A 140
ILE A 110
ALA A 139
LEU A 129
ASN A 133
 None
 1.25A 3o01A-1e7sA:
0.0
3o01B-1e7sA:
0.0		 3o01A-1e7sA:
22.78
3o01B-1e7sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 5 VAL A  47
ILE A  91
MET A 225
ARG A  36
 None
None
None
NAP  A1317 (-3.6A)
 1.33A 3pyyB-1e7sA:
0.1		 3pyyB-1e7sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 245
LEU A 290
LEU A 212
ALA A 219
SER A 221
 None
 1.09A 3rr3C-1e7sA:
undetectable		 3rr3C-1e7sA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 245
LEU A 290
LEU A 212
ALA A 219
SER A 221
 None
 1.10A 3rr3D-1e7sA:
undetectable		 3rr3D-1e7sA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 245
LEU A 290
LEU A 212
ALA A 219
SER A 221
 None
 0.98A 4m11B-1e7sA:
0.0		 4m11B-1e7sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		3 / 3 MET A  14
MET A 162
TYR A 167
 NAP  A1317 (-3.0A)
None
None
 1.19A 4p6xI-1e7sA:
0.0		 4p6xI-1e7sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 6 SER A 221
GLY A 246
MET A 217
ILE A 243
 None
 1.16A 5j4nA-1e7sA:
0.0		 5j4nA-1e7sA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A 260
ALA A 257
PHE A 272
ALA A 261
VAL A 199
 None
 1.06A 5n0oB-1e7sA:
0.0		 5n0oB-1e7sA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 5 HIS A 242
MET A 119
VAL A 287
LEU A 285
 None
 1.33A 5xdhB-1e7sA:
0.0		 5xdhB-1e7sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 5 HIS A 242
MET A 119
VAL A 287
LEU A 285
 None
 1.21A 5xdhD-1e7sA:
undetectable		 5xdhD-1e7sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 1e7s GDP-FUCOSE
SYNTHETASE
(Escherichia
coli) 		4 / 5 GLU A 148
PRO A 238
THR A 236
GLN A 237
 None
SO4  A1320 (-4.4A)
None
None
 1.43A 6fgdA-1e7sA:
3.2		 6fgdA-1e7sA:
23.20