SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1e8a S100A12
(Homo
sapiens) 		5 / 12 ILE A  44
ILE A  79
ALA A  83
LEU A  40
ILE A  10
 None
 1.12A 1xzxX-1e8aA:
undetectable		 1xzxX-1e8aA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1e8a S100A12
(Homo
sapiens) 		5 / 8 LEU A  35
VAL A  77
LEU A  76
ILE A  10
LEU A  40
 None
 1.29A 3kp6A-1e8aA:
undetectable
3kp6B-1e8aA:
undetectable		 3kp6A-1e8aA:
24.50
3kp6B-1e8aA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1e8a S100A12
(Homo
sapiens) 		4 / 6 ILE A  56
PHE A  57
GLY A  59
ILE A  79
 None
 0.78A 4o8fB-1e8aA:
undetectable		 4o8fB-1e8aA:
15.55