SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 ARG A 341
THR A 154
VAL A 143
 None
 0.99A 1hxbA-1e8cA:
0.0		 1hxbA-1e8cA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 11 LEU A 312
LEU A 329
GLU A 297
LEU A 328
VAL A 308
 None
 1.16A 1ictA-1e8cA:
0.0
1ictC-1e8cA:
undetectable		 1ictA-1e8cA:
13.45
1ictC-1e8cA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 TRP A 248
ALA A 240
VAL A 244
 None
 0.89A 1kqeA-1e8cA:
undetectable
1kqeE-1e8cA:
undetectable		 1kqeA-1e8cA:
3.74
1kqeE-1e8cA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 11 LEU A  86
ILE A  63
LEU A  36
PHE A  37
ARG A  48
 None
None
None
UAG  A1498 ( 4.7A)
None
 1.37A 2bxmA-1e8cA:
0.0		 2bxmA-1e8cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 9 SER A 292
THR A 122
VAL A 258
ILE A 237
VAL A 202
 None
 1.33A 2nnhB-1e8cA:
0.0		 2nnhB-1e8cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 ARG A 341
THR A 154
VAL A 143
 None
 0.89A 2q64A-1e8cA:
0.0		 2q64A-1e8cA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 6 VAL A 113
SER A 309
LEU A 328
ILE A 287
ALA A 314
 None
 1.27A 3kk6B-1e8cA:
0.0		 3kk6B-1e8cA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 7 LEU A 312
SER A 309
LEU A 328
ILE A 287
 None
 0.94A 3ln1B-1e8cA:
0.0		 3ln1B-1e8cA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 9 LEU A 329
LEU A 325
LEU A 312
LEU A 273
SER A 291
 None
 1.44A 3q1eB-1e8cA:
0.0
3q1eD-1e8cA:
0.0		 3q1eB-1e8cA:
12.05
3q1eD-1e8cA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 5 HIS A 214
GLN A 190
GLY A 187
SER A 185
 None
UAG  A1498 (-2.8A)
None
KCX  A 224 ( 4.0A)
 1.17A 4fu8A-1e8cA:
undetectable		 4fu8A-1e8cA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 7 ARG A 341
GLY A 118
GLU A 182
MET A 397
 None
 0.97A 4g0vA-1e8cA:
2.1		 4g0vA-1e8cA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 6 ARG A 341
GLY A 118
GLU A 182
MET A 397
 None
 1.04A 4g0vB-1e8cA:
undetectable		 4g0vB-1e8cA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 6 ARG A 443
GLY A 442
ASP A 413
PRO A 415
 None
None
API  A1499 (-3.6A)
None
 1.05A 4lajA-1e8cA:
0.0
4lajB-1e8cA:
0.0		 4lajA-1e8cA:
19.85
4lajB-1e8cA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 6 THR A 157
GLU A 182
THR A 158
HIS A 214
 UAG  A1498 (-3.9A)
None
UAG  A1498 (-4.3A)
None
 0.98A 4pgfA-1e8cA:
2.4		 4pgfA-1e8cA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 5 THR A 122
THR A 123
HIS A 359
ASN A 205
 None
None
API  A1499 (-3.7A)
None
 1.28A 4pgfB-1e8cA:
2.6		 4pgfB-1e8cA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 7 GLU A 468
THR A 142
THR A 157
HIS A 359
 API  A1499 (-3.1A)
None
UAG  A1498 (-3.9A)
API  A1499 (-3.7A)
 0.91A 4qwpB-1e8cA:
undetectable		 4qwpB-1e8cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 SER A 259
ALA A 257
VAL A 256
 None
 0.63A 4x20C-1e8cA:
undetectable		 4x20C-1e8cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 8 ALA A  60
VAL A  81
GLY A  34
ALA A  33
GLY A  58
 None
 1.32A 4zjzB-1e8cA:
undetectable		 4zjzB-1e8cA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 10 ALA A 454
ALA A 450
VAL A 382
LEU A 490
VAL A 462
 None
 1.41A 5eb5B-1e8cA:
undetectable		 5eb5B-1e8cA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 4 THR A 114
LEU A 188
HIS A 231
GLY A 187
 KCX  A 224 ( 3.9A)
KCX  A 224 ( 4.9A)
None
None
 1.42A 5gwyA-1e8cA:
0.0		 5gwyA-1e8cA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 4 LEU A 329
ARG A 288
ILE A 298
PHE A 289
 None
 1.16A 5kirB-1e8cA:
0.0		 5kirB-1e8cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 GLU A 468
HIS A 467
ARG A 483
 API  A1499 (-3.1A)
None
None
 0.99A 5uunA-1e8cA:
0.5		 5uunA-1e8cA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 8 ARG A  22
ALA A  60
THR A  25
GLY A  58
 None
 1.00A 5v0vA-1e8cA:
0.0		 5v0vA-1e8cA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 THR A 142
THR A 120
ARG A 341
 None
 0.81A 5wm2A-1e8cA:
2.3		 5wm2A-1e8cA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 5 PRO A 104
GLY A  98
TYR A 101
VAL A 164
 None
 1.28A 5x80C-1e8cA:
0.0
5x80D-1e8cA:
0.0		 5x80C-1e8cA:
15.90
5x80D-1e8cA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 12 ALA A 180
THR A 120
GLY A 141
LEU A 321
PHE A 178
 None
 1.18A 5ybbA-1e8cA:
2.4		 5ybbA-1e8cA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 GLN A 453
TRP A 380
VAL A 460
 None
 0.81A 6auuA-1e8cA:
0.0		 6auuA-1e8cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 12 PHE A 383
GLY A 387
VAL A 439
ILE A 424
ASP A 426
 None
 1.19A 6bxmA-1e8cA:
2.3		 6bxmA-1e8cA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		5 / 12 ASN A 205
ASN A 239
ASN A 310
ASP A 356
ASP A 362
 None
 1.37A 6dwnA-1e8cA:
0.0		 6dwnA-1e8cA:
10.41