SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 LEU A 106
GLY A 109
ALA B 440
GLY B 443
LEU B 562
 None
 1.11A 1fe2A-1e9yA:
0.0		 1fe2A-1e9yA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FWE_C_HAEC989_1
(UREASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		6 / 6 HIS B 136
HIS B 138
HIS B 221
HIS B 248
HIS B 274
ASP B 362
 NI  B3002 (-3.5A)
NI  B3002 (-3.3A)
KCX  B 219 (-4.0A)
NI  B3001 ( 3.4A)
NI  B3001 ( 3.5A)
HAE  B 800 ( 2.5A)
 0.26A 1fweC-1e9yB:
60.2		 1fweC-1e9yB:
61.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 6 PHE B 334
ILE B 328
ALA B 335
MET B 315
 None
 1.27A 1hk2A-1e9yB:
0.0		 1hk2A-1e9yB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		6 / 12 GLY B 452
ALA B 432
ASP B 433
ILE B  86
GLY B 429
ILE B  88
 None
 1.49A 1hshA-1e9yB:
undetectable		 1hshA-1e9yB:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 7 ARG B  22
VAL A 107
ASP B  27
LYS B 385
 None
 1.20A 1hwiC-1e9yB:
0.0		 1hwiC-1e9yB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 7 ARG B  22
VAL A 107
ASP B  27
LYS B 385
 None
 1.20A 1hwiD-1e9yB:
0.0		 1hwiD-1e9yB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 ARG B  22
VAL A 107
ASP B  27
LYS B 385
 None
 1.23A 1hwkA-1e9yB:
0.0		 1hwkA-1e9yB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 ARG B  22
VAL A 107
ASP B  27
LYS B 385
 None
 1.21A 1hwkC-1e9yB:
0.0		 1hwkC-1e9yB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 ARG B  22
VAL A 107
ASP B  27
LYS B 385
 None
 1.21A 1hwkD-1e9yB:
0.0		 1hwkD-1e9yB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 LEU A 106
GLY A 109
ALA B 440
GLY B 443
LEU B 562
 None
 1.07A 1igxA-1e9yA:
0.0		 1igxA-1e9yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ILE B  88
LEU B  68
GLY B  97
ALA B  73
VAL B 128
 None
 1.11A 1jg2A-1e9yB:
undetectable		 1jg2A-1e9yB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 SER B  58
ASP B 103
GLU B  65
GLU B  64
 None
 1.10A 1knyA-1e9yB:
0.0
1knyB-1e9yB:
0.0		 1knyA-1e9yB:
17.83
1knyB-1e9yB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 6 ASN A 121
ARG A 165
ILE B  38
GLY B  40
 None
 1.07A 1oniA-1e9yA:
0.0
1oniB-1e9yA:
undetectable		 1oniA-1e9yA:
20.19
1oniB-1e9yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 6 ASN A 121
ARG A 165
ILE B  38
GLY B  40
 None
 1.12A 1oniD-1e9yA:
undetectable
1oniF-1e9yA:
0.0		 1oniD-1e9yA:
20.19
1oniF-1e9yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B  71
GLY B  99
GLN B 105
ILE B  69
 None
 0.93A 1rxcB-1e9yB:
undetectable		 1rxcB-1e9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 170
GLY B 159
ILE B 172
PRO B 174
 None
None
KCX  B 219 ( 4.4A)
None
 0.95A 1rxcB-1e9yB:
undetectable		 1rxcB-1e9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B  71
GLY B  99
GLN B 105
ILE B  69
 None
 0.93A 1rxcE-1e9yB:
undetectable		 1rxcE-1e9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 170
GLY B 159
ILE B 172
PRO B 174
 None
None
KCX  B 219 ( 4.4A)
None
 0.97A 1rxcE-1e9yB:
undetectable		 1rxcE-1e9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 170
GLY B 159
ILE B 172
PRO B 174
 None
None
KCX  B 219 ( 4.4A)
None
 0.97A 1rxcI-1e9yB:
undetectable		 1rxcI-1e9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B  71
GLY B  99
GLN B 105
ILE B  69
 None
 0.97A 1rxcK-1e9yB:
undetectable		 1rxcK-1e9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 170
GLY B 159
ILE B 172
PRO B 174
 None
None
KCX  B 219 ( 4.4A)
None
 0.92A 1rxcK-1e9yB:
undetectable		 1rxcK-1e9yB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 ALA B 346
ILE B 287
ILE B 536
PRO B 284
 None
 0.70A 1sh9A-1e9yB:
0.0		 1sh9A-1e9yB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 ASP B 250
GLY B 279
GLY B 280
PHE B 334
HIS B 322
 None
HAE  B 800 ( 4.5A)
None
None
None
 1.12A 1w76B-1e9yB:
undetectable		 1w76B-1e9yB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ASN B 200
ALA B 230
LEU B 235
MET B 270
THR B 170
 KCX  B 219 ( 4.2A)
None
None
None
None
 1.38A 1ya3A-1e9yB:
undetectable		 1ya3A-1e9yB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 4 GLY A  73
SER A  76
VAL A  70
LEU B 565
 None
 1.25A 1yajB-1e9yA:
undetectable		 1yajB-1e9yA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ASN B 200
ALA B 230
LEU B 235
MET B 270
THR B 170
 KCX  B 219 ( 4.2A)
None
None
None
None
 1.32A 2aa5A-1e9yB:
undetectable		 2aa5A-1e9yB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ASN B 200
ALA B 230
LEU B 235
MET B 270
THR B 170
 KCX  B 219 ( 4.2A)
None
None
None
None
 1.36A 2aa6A-1e9yB:
undetectable		 2aa6A-1e9yB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ASN B 200
ALA B 230
LEU B 235
MET B 270
THR B 170
 KCX  B 219 ( 4.2A)
None
None
None
None
 1.39A 2aa6B-1e9yB:
undetectable		 2aa6B-1e9yB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 ALA B 185
ALA B 186
ASN B 192
PHE B 139
ILE B 216
 None
 1.17A 2aclC-1e9yB:
0.0		 2aclC-1e9yB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ALA B  84
VAL B 128
ILE B  70
GLY B  87
ILE B  75
 None
 0.86A 2avoB-1e9yB:
undetectable		 2avoB-1e9yB:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 ASP B 433
ILE B 145
VAL B 372
 None
 0.56A 2avvD-1e9yB:
undetectable		 2avvD-1e9yB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 THR B 303
PRO B 305
PRO B 302
 None
 0.85A 2d55C-1e9yB:
undetectable		 2d55C-1e9yB:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 THR B 251
ASP B 362
SER B 360
 None
HAE  B 800 ( 2.5A)
None
 0.84A 2nxeA-1e9yB:
undetectable		 2nxeA-1e9yB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 THR B 251
ASP B 362
SER B 360
 None
HAE  B 800 ( 2.5A)
None
 0.78A 2nxeB-1e9yB:
undetectable		 2nxeB-1e9yB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1e9y UREASE SUBUNIT ALPHA
(Helicobacter
pylori) 		3 / 3 VAL A 202
ASP A 203
GLU A 149
 None
 0.62A 2qeuA-1e9yA:
0.4		 2qeuA-1e9yA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1e9y UREASE SUBUNIT ALPHA
(Helicobacter
pylori) 		3 / 3 VAL A 202
ASP A 203
GLU A 149
 None
 0.62A 2qeuC-1e9yA:
0.4		 2qeuC-1e9yA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ALA B  84
VAL B 128
ILE B  70
GLY B  87
ILE B  75
 None
 0.89A 2r5pB-1e9yB:
undetectable		 2r5pB-1e9yB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 TRP B 437
VAL B  76
ILE B 127
LEU B 562
GLY B  24
 None
 1.26A 2xf3B-1e9yB:
0.0		 2xf3B-1e9yB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 TRP B 437
VAL B  76
ILE B 127
LEU B 562
GLY B  24
 None
 1.27A 2xfsB-1e9yB:
0.0		 2xfsB-1e9yB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 TRP B 437
VAL B  76
ILE B 127
LEU B 562
GLY B  24
 None
 1.26A 2xh9B-1e9yB:
0.0		 2xh9B-1e9yB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 GLY B 279
GLY B 281
PHE B 334
HIS B 322
HIS B 221
 HAE  B 800 ( 4.5A)
None
None
None
KCX  B 219 (-4.0A)
 1.44A 2y7kA-1e9yB:
0.0		 2y7kA-1e9yB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 210
THR B 173
THR B 492
LEU B 507
 None
 1.37A 2zj0A-1e9yB:
undetectable		 2zj0A-1e9yB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 MET B 366
GLU B 222
ASN B 253
 HAE  B 800 ( 4.6A)
None
None
 0.92A 3a27A-1e9yB:
undetectable		 3a27A-1e9yB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 GLY B 159
ALA B 197
PHE B 195
LEU B 183
ARG B 511
 None
 1.35A 3a3yA-1e9yB:
0.0		 3a3yA-1e9yB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 GLY B 160
ALA B 197
PHE B 195
LEU B 183
ARG B 511
 None
 1.37A 3a3yA-1e9yB:
0.0		 3a3yA-1e9yB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 TYR B  39
ASP B  19
SER B   5
TYR B   9
ILE A 118
 None
 1.07A 3b7pC-1e9yB:
undetectable		 3b7pC-1e9yB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 TYR B  39
ASP B  35
SER B   5
TYR B   9
ILE A 118
 None
 1.43A 3b7pC-1e9yB:
undetectable		 3b7pC-1e9yB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 HIS B 282
GLU B 222
HIS B 248
 None
None
NI  B3001 ( 3.4A)
 0.78A 3ba0A-1e9yB:
undetectable		 3ba0A-1e9yB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 PRO B 413
PHE B 529
LYS B 408
 None
 1.26A 3bjwG-1e9yB:
1.2		 3bjwG-1e9yB:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 GLY B  24
ASP B  25
SER B 561
 None
 0.70A 3brfA-1e9yB:
0.0		 3brfA-1e9yB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 210
THR B 173
THR B 492
LEU B 507
 None
 1.35A 3ce6A-1e9yB:
undetectable		 3ce6A-1e9yB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 210
THR B 173
THR B 492
LEU B 507
 None
 1.32A 3ce6C-1e9yB:
2.0		 3ce6C-1e9yB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 4 ILE B 220
GLN B 244
ILE B 172
LEU B 296
 KCX  B 219 ( 3.8A)
None
KCX  B 219 ( 4.4A)
None
 0.98A 3dzyD-1e9yB:
0.0		 3dzyD-1e9yB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ALA B 185
ALA B 186
ASN B 192
PHE B 139
ILE B 216
 None
 1.09A 3e00A-1e9yB:
undetectable		 3e00A-1e9yB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 ASP B 362
ILE B 137
GLY B 159
ILE B 172
ILE B 140
 HAE  B 800 ( 2.5A)
None
None
KCX  B 219 ( 4.4A)
None
 1.27A 3ekyB-1e9yB:
undetectable		 3ekyB-1e9yB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 TYR B  78
LEU B 406
GLY B 354
ILE B 415
 None
 0.80A 3jusB-1e9yB:
undetectable		 3jusB-1e9yB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 ILE B 287
PHE B 356
THR B 349
VAL B 547
VAL B 545
 None
 1.15A 3me6D-1e9yB:
0.0		 3me6D-1e9yB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 LEU B 126
ILE B  93
GLY B  87
ILE B  69
VAL B 128
 None
 0.98A 3so9B-1e9yB:
undetectable		 3so9B-1e9yB:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 471
TYR B 475
LEU A  11
LYS A  10
 None
 1.35A 3sugA-1e9yB:
0.0		 3sugA-1e9yB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.98A 3w9tA-1e9yB:
0.0		 3w9tA-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 6 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.97A 3w9tB-1e9yB:
0.0		 3w9tB-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.97A 3w9tC-1e9yB:
0.0		 3w9tC-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.97A 3w9tD-1e9yB:
0.0		 3w9tD-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 6 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.98A 3w9tE-1e9yB:
0.0		 3w9tE-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 6 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.99A 3w9tF-1e9yB:
0.0		 3w9tF-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 ASP B  77
GLY B 424
TYR B  78
GLU B 427
 None
 0.98A 3w9tG-1e9yB:
0.0		 3w9tG-1e9yB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ILE B 419
THR B 492
GLY B 214
ILE B 491
VAL B 513
 None
 1.03A 4c9lA-1e9yB:
undetectable		 4c9lA-1e9yB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ILE B 419
THR B 492
GLY B 214
ILE B 491
VAL B 513
 None
 1.02A 4c9lB-1e9yB:
undetectable		 4c9lB-1e9yB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ILE B 419
THR B 492
GLY B 214
ILE B 491
VAL B 513
 None
 1.06A 4c9oA-1e9yB:
undetectable		 4c9oA-1e9yB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ILE B 419
THR B 492
GLY B 214
ILE B 491
VAL B 513
 None
 1.07A 4c9oB-1e9yB:
undetectable		 4c9oB-1e9yB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B  71
GLY B  99
GLN B 105
ILE B  69
 None
 0.96A 4e1vC-1e9yB:
undetectable		 4e1vC-1e9yB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 170
GLY B 159
ILE B 172
PRO B 174
 None
None
KCX  B 219 ( 4.4A)
None
 0.96A 4e1vC-1e9yB:
undetectable		 4e1vC-1e9yB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 170
GLY B 159
ILE B 172
PRO B 174
 None
None
KCX  B 219 ( 4.4A)
None
 0.98A 4e1vD-1e9yB:
undetectable		 4e1vD-1e9yB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B  71
GLY B  99
GLN B 105
ILE B  69
 None
 0.93A 4e1vE-1e9yB:
undetectable		 4e1vE-1e9yB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 170
GLY B 159
ILE B 172
PRO B 174
 None
None
KCX  B 219 ( 4.4A)
None
 0.93A 4e1vH-1e9yB:
undetectable		 4e1vH-1e9yB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1e9y UREASE SUBUNIT ALPHA
(Helicobacter
pylori) 		5 / 9 GLU A  60
GLY A  61
VAL A  96
PRO A  99
GLU A  34
 None
 1.24A 4fimA-1e9yA:
undetectable		 4fimA-1e9yA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H9M_A_HAEA929_1
(UREASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 5 HIS B 136
HIS B 221
HIS B 248
HIS B 274
ASP B 362
 NI  B3002 (-3.5A)
KCX  B 219 (-4.0A)
NI  B3001 ( 3.4A)
NI  B3001 ( 3.5A)
HAE  B 800 ( 2.5A)
 0.29A 4h9mA-1e9yB:
58.1		 4h9mA-1e9yB:
40.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 7 ILE B  93
LEU B 434
LYS B  83
GLY B 123
 None
 0.74A 4hajA-1e9yB:
undetectable		 4hajA-1e9yB:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 ILE B  93
LEU B 434
LYS B  83
GLY B 123
 None
 0.78A 4hb8A-1e9yB:
undetectable		 4hb8A-1e9yB:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 ILE B  93
GLY B 452
GLY B  91
ILE B 450
ALA B 456
 None
 1.10A 4kicB-1e9yB:
undetectable		 4kicB-1e9yB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 342
THR B 343
THR B 251
LEU B 318
 None
 1.12A 4lvcA-1e9yB:
undetectable		 4lvcA-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 342
THR B 343
THR B 251
LEU B 318
 None
 1.11A 4lvcC-1e9yB:
2.2		 4lvcC-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 VAL B 237
ALA B 238
TYR B 241
SER B 495
GLY B 217
 None
 1.39A 4mmeA-1e9yB:
0.0		 4mmeA-1e9yB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 6 THR B 303
GLU B 347
THR B 300
THR B 251
 None
 1.08A 4pgfA-1e9yB:
undetectable		 4pgfA-1e9yB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.00A 4qvlK-1e9yB:
undetectable
4qvlL-1e9yB:
undetectable		 4qvlK-1e9yB:
17.51
4qvlL-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.99A 4qvlY-1e9yB:
undetectable
4qvlZ-1e9yB:
undetectable		 4qvlY-1e9yB:
17.51
4qvlZ-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.01A 4qvmK-1e9yB:
undetectable
4qvmL-1e9yB:
undetectable		 4qvmK-1e9yB:
16.97
4qvmL-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.48A 4qvmH-1e9yB:
undetectable
4qvmN-1e9yB:
undetectable		 4qvmH-1e9yB:
18.56
4qvmN-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.01A 4qvmY-1e9yB:
undetectable
4qvmZ-1e9yB:
undetectable		 4qvmY-1e9yB:
16.97
4qvmZ-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 4qvpV-1e9yB:
undetectable
4qvpb-1e9yB:
undetectable		 4qvpV-1e9yB:
18.56
4qvpb-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.02A 4qvpK-1e9yB:
undetectable
4qvpL-1e9yB:
undetectable		 4qvpK-1e9yB:
17.15
4qvpL-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 4qvpH-1e9yB:
undetectable
4qvpN-1e9yB:
undetectable		 4qvpH-1e9yB:
18.56
4qvpN-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.01A 4qvpY-1e9yB:
undetectable
4qvpZ-1e9yB:
undetectable		 4qvpY-1e9yB:
17.15
4qvpZ-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 4qvqV-1e9yB:
undetectable
4qvqb-1e9yB:
undetectable		 4qvqV-1e9yB:
18.56
4qvqb-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.48A 4qvqH-1e9yB:
undetectable
4qvqN-1e9yB:
undetectable		 4qvqH-1e9yB:
18.56
4qvqN-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 272
GLY B 281
GLY B 280
ASP B 362
 None
None
None
HAE  B 800 ( 2.5A)
 0.84A 4qvvK-1e9yB:
undetectable
4qvvL-1e9yB:
undetectable		 4qvvK-1e9yB:
17.51
4qvvL-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 THR B 272
GLY B 281
GLY B 280
ASP B 362
 None
None
None
HAE  B 800 ( 2.5A)
 0.84A 4qvvY-1e9yB:
undetectable
4qvvZ-1e9yB:
undetectable		 4qvvY-1e9yB:
17.51
4qvvZ-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.98A 4qvwK-1e9yB:
undetectable
4qvwL-1e9yB:
undetectable		 4qvwK-1e9yB:
17.51
4qvwL-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.98A 4qvwY-1e9yB:
undetectable
4qvwZ-1e9yB:
undetectable		 4qvwY-1e9yB:
17.51
4qvwZ-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 4qw1V-1e9yB:
undetectable
4qw1b-1e9yB:
undetectable		 4qw1V-1e9yB:
18.56
4qw1b-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.01A 4qw1K-1e9yB:
undetectable
4qw1L-1e9yB:
undetectable		 4qw1K-1e9yB:
17.33
4qw1L-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.48A 4qw1H-1e9yB:
undetectable
4qw1N-1e9yB:
undetectable		 4qw1H-1e9yB:
18.56
4qw1N-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.01A 4qw1Y-1e9yB:
undetectable
4qw1Z-1e9yB:
undetectable		 4qw1Y-1e9yB:
17.33
4qw1Z-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 4qw3V-1e9yB:
undetectable
4qw3b-1e9yB:
undetectable		 4qw3V-1e9yB:
18.56
4qw3b-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 1.00A 4qw3K-1e9yB:
undetectable
4qw3L-1e9yB:
undetectable		 4qw3K-1e9yB:
17.51
4qw3L-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 4qw3H-1e9yB:
undetectable
4qw3N-1e9yB:
undetectable		 4qw3H-1e9yB:
18.56
4qw3N-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 10 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.99A 4qw3Y-1e9yB:
undetectable
4qw3Z-1e9yB:
undetectable		 4qw3Y-1e9yB:
17.51
4qw3Z-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.45A 4qwuV-1e9yB:
undetectable
4qwub-1e9yB:
undetectable		 4qwuV-1e9yB:
18.56
4qwub-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.46A 4qwuH-1e9yB:
undetectable
4qwuN-1e9yB:
undetectable		 4qwuH-1e9yB:
18.56
4qwuN-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1e9y UREASE SUBUNIT ALPHA
(Helicobacter
pylori) 		4 / 8 LEU A  64
VAL A  70
LEU A  30
GLY A  17
 None
 0.83A 4r3aA-1e9yA:
undetectable		 4r3aA-1e9yA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		6 / 6 HIS B 136
HIS B 138
HIS B 221
HIS B 248
HIS B 274
ASP B 362
 NI  B3002 (-3.5A)
NI  B3002 (-3.3A)
KCX  B 219 (-4.0A)
NI  B3001 ( 3.4A)
NI  B3001 ( 3.5A)
HAE  B 800 ( 2.5A)
 0.27A 4ubpC-1e9yB:
51.0		 4ubpC-1e9yB:
61.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		4 / 5 GLY A 171
THR A 172
HIS A 144
GLY B  40
 None
 1.10A 4v20A-1e9yA:
0.0		 4v20A-1e9yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1e9y UREASE SUBUNIT ALPHA
(Helicobacter
pylori) 		3 / 3 ASP A 157
GLY A 225
ASP A 155
 None
 0.67A 4xdtA-1e9yA:
0.0		 4xdtA-1e9yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.99A 5bxnK-1e9yB:
undetectable
5bxnL-1e9yB:
undetectable		 5bxnK-1e9yB:
17.51
5bxnL-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.98A 5bxnY-1e9yB:
undetectable
5bxnZ-1e9yB:
undetectable		 5bxnY-1e9yB:
17.51
5bxnZ-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.99A 5d0xK-1e9yB:
undetectable
5d0xL-1e9yB:
undetectable		 5d0xK-1e9yB:
17.52
5d0xL-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 THR B 272
ALA B 298
GLY B 281
GLY B 280
ASP B 362
 None
None
None
None
HAE  B 800 ( 2.5A)
 0.99A 5d0xY-1e9yB:
undetectable
5d0xZ-1e9yB:
undetectable		 5d0xY-1e9yB:
17.52
5d0xZ-1e9yB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 ILE A 100
GLY A  73
LEU B 565
ASN A  31
 None
 1.06A 5hwaA-1e9yA:
undetectable		 5hwaA-1e9yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 ALA B 246
ILE B 216
GLY B 158
ILE B 137
PRO B 413
 KCX  B 219 ( 4.3A)
None
None
None
None
 1.28A 5kr2A-1e9yB:
undetectable		 5kr2A-1e9yB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 9 ALA B 246
ILE B 216
GLY B 158
ILE B 137
PRO B 413
 KCX  B 219 ( 4.3A)
None
None
None
None
 1.26A 5kr2C-1e9yB:
undetectable		 5kr2C-1e9yB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 5l5fH-1e9yB:
0.0
5l5fN-1e9yB:
0.0		 5l5fH-1e9yB:
18.56
5l5fN-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 11 SER B 363
THR B 171
THR B 170
THR B 167
THR B 300
 None
KCX  B 219 ( 3.0A)
None
None
None
 1.47A 5l66H-1e9yB:
undetectable
5l66N-1e9yB:
undetectable		 5l66H-1e9yB:
18.56
5l66N-1e9yB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 8 ILE B 286
THR B 343
VAL B 545
HIS B 535
VAL B 538
 None
 1.39A 5l94A-1e9yB:
0.0		 5l94A-1e9yB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		3 / 3 MET B 104
GLN B 105
ARG A 165
 None
 1.07A 5m35B-1e9yB:
undetectable		 5m35B-1e9yB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		3 / 3 MET B 104
GLN B 105
ARG A 165
 None
 1.07A 5m36A-1e9yB:
undetectable		 5m36A-1e9yB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 4 GLN B 210
THR B 173
THR B 492
LEU B 507
 None
 1.48A 5m5kA-1e9yB:
2.2		 5m5kA-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 4 GLN B 342
THR B 343
THR B 251
LEU B 318
 None
 1.16A 5m5kA-1e9yB:
2.2		 5m5kA-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 4 GLN B 210
THR B 173
THR B 492
LEU B 507
 None
 1.48A 5m5kC-1e9yB:
2.3		 5m5kC-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 4 GLN B 342
THR B 343
THR B 251
LEU B 318
 None
 1.16A 5m5kC-1e9yB:
2.3		 5m5kC-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 8 ILE B 358
ALA B 416
ILE B 157
ILE B 133
 None
 0.75A 5mvmA-1e9yB:
undetectable
5mvmB-1e9yB:
undetectable		 5mvmA-1e9yB:
10.42
5mvmB-1e9yB:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 4 ASP B 362
HIS B 274
HIS B 248
HIS B 138
 HAE  B 800 ( 2.5A)
NI  B3001 ( 3.5A)
NI  B3001 ( 3.4A)
NI  B3002 (-3.3A)
 1.49A 5ncdD-1e9yB:
2.2		 5ncdD-1e9yB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 ALA B 213
VAL B 237
TYR B 241
 None
 0.59A 5zmqH-1e9yB:
0.0		 5zmqH-1e9yB:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		5 / 12 PHE B 195
VAL B 369
THR B 171
GLY B 159
GLY B 160
 None
None
KCX  B 219 ( 3.0A)
None
None
 1.01A 6brdB-1e9yB:
undetectable		 6brdB-1e9yB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 THR B 269
ARG B 520
THR B 135
ASP B 362
 None
None
None
HAE  B 800 ( 2.5A)
 1.32A 6ectA-1e9yB:
1.3		 6ectA-1e9yB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 THR B 269
ARG B 520
THR B 135
ASP B 362
 None
None
None
HAE  B 800 ( 2.5A)
 1.40A 6ecxA-1e9yB:
undetectable		 6ecxA-1e9yB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		3 / 3 MET B 104
GLN B 105
ARG A 165
 None
 1.06A 6fn9A-1e9yB:
undetectable		 6fn9A-1e9yB:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		3 / 3 MET B 104
GLN B 105
ARG A 165
 None
 1.08A 6fnaB-1e9yB:
1.2		 6fnaB-1e9yB:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA
(Helicobacter
pylori;
Helicobacter
pylori) 		3 / 3 MET B 104
GLN B 105
ARG A 165
 None
 1.06A 6fnbA-1e9yB:
undetectable		 6fnbA-1e9yB:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 342
THR B 343
THR B 251
LEU B 318
 None
 1.14A 6gbnA-1e9yB:
2.0		 6gbnA-1e9yB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		4 / 5 GLN B 342
THR B 343
THR B 251
LEU B 318
 None
 1.14A 6gbnD-1e9yB:
undetectable		 6gbnD-1e9yB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1e9y UREASE SUBUNIT BETA
(Helicobacter
pylori) 		3 / 3 ARG B 401
PHE B 356
PHE B 387
 None
 0.70A 6nknC-1e9yB:
0.0
6nknJ-1e9yB:
0.0		 6nknC-1e9yB:
17.77
6nknJ-1e9yB:
7.57