SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ea6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		4 / 8 SER A  46
VAL A  43
LEU A  56
VAL A 214
 ADP  A1366 ( 3.9A)
None
None
None
 1.09A 1fduB-1ea6A:
undetectable		 1fduB-1ea6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 10 GLY A  50
ALA A  51
ASP A  70
VAL A 200
ILE A 198
 None
None
ADP  A1366 (-3.4A)
None
None
 0.97A 1muiA-1ea6A:
undetectable		 1muiA-1ea6A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
 0.58A 1s14A-1ea6A:
15.1		 1s14A-1ea6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 12 GLY A  62
VAL A 159
LEU A  35
SER A  34
LEU A 114
 None
 1.28A 1ya4B-1ea6A:
undetectable		 1ya4B-1ea6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		4 / 6 ALA A 196
SER A 220
ASN A 226
ILE A 227
 None
 0.78A 1yc2A-1ea6A:
undetectable		 1yc2A-1ea6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		4 / 8 VAL A  43
TYR A 191
THR A  37
LEU A 188
 None
 0.97A 1z2bB-1ea6A:
undetectable		 1z2bB-1ea6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 8 VAL A 120
LEU A 114
ILE A 122
VAL A 157
LEU A  42
 None
 1.30A 3kp6A-1ea6A:
undetectable
3kp6B-1ea6A:
undetectable		 3kp6A-1ea6A:
19.09
3kp6B-1ea6A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
 0.53A 3lpsA-1ea6A:
17.0		 3lpsA-1ea6A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		4 / 5 VAL A 187
PHE A 231
ILE A 193
PHE A 320
 None
 1.06A 3owxB-1ea6A:
0.0		 3owxB-1ea6A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		3 / 3 ASP A  55
ARG A 211
LYS A  57
 None
 1.18A 3wipG-1ea6A:
0.0		 3wipG-1ea6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		4 / 7 VAL A 321
VAL A 309
PHE A 363
ILE A 240
 None
 0.93A 3zjqA-1ea6A:
0.0		 3zjqA-1ea6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		4 / 7 VAL A 321
VAL A 309
PHE A 363
ILE A 240
 None
 0.93A 3zjqB-1ea6A:
0.0		 3zjqB-1ea6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 12 ILE A  66
THR A 155
LEU A  42
LEU A  83
LEU A 111
 None
ADP  A1366 ( 4.0A)
None
ADP  A1366 (-4.9A)
ADP  A1366 (-3.9A)
 1.45A 4qynB-1ea6A:
0.0		 4qynB-1ea6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		3 / 3 ARG A 151
GLU A  67
TYR A 149
 None
 1.00A 4r29D-1ea6A:
0.0		 4r29D-1ea6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 11 ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
 0.44A 4urnA-1ea6A:
15.4		 4urnA-1ea6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 11 ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
 0.43A 4urnB-1ea6A:
15.7		 4urnB-1ea6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 11 ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
 0.41A 4urnC-1ea6A:
15.4		 4urnC-1ea6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		3 / 3 GLU A  44
ILE A 292
ALA A 190
 None
 0.60A 4wnwB-1ea6A:
0.0		 4wnwB-1ea6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL6_A_ASDA601_1
(AROMATASE)		 1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens) 		5 / 9 ILE A 198
THR A 217
VAL A 215
MET A 184
LEU A  56
 None
 1.13A 5jl6A-1ea6A:
0.0		 5jl6A-1ea6A:
20.00