SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ea9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
6 / 12 HIS C 201
TYR C 203
ASP C 238
HIS C 420
ASP C 421
ARG C 469
None
1.39A 1dedA-1ea9C:
31.3
1dedA-1ea9C:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
7 / 12 HIS C 201
TYR C 203
ARG C 323
GLU C 354
HIS C 420
ASP C 421
ARG C 469
None
0.81A 1dedB-1ea9C:
32.3
1dedB-1ea9C:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 6 ASN C 328
HIS C 332
ALA C 327
GLY C 353
None
1.06A 1gfzA-1ea9C:
undetectable
1gfzA-1ea9C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
7 / 12 TYR C 203
HIS C 243
PHE C 286
ARG C 323
GLU C 354
HIS C 420
ASP C 421
None
0.98A 1mxdA-1ea9C:
23.3
1mxdA-1ea9C:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 LYS C   1
ILE C  27
THR C  61
None
0.79A 1rx3A-1ea9C:
0.0
1rx3A-1ea9C:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 ASP C 320
PHE C 191
ASN C 187
None
0.80A 1sg9B-1ea9C:
undetectable
1sg9B-1ea9C:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 8 TYR C 134
TRP C 474
LEU C 460
MET C 472
None
1.27A 1uw6G-1ea9C:
2.2
1uw6H-1ea9C:
2.2
1uw6G-1ea9C:
15.99
1uw6H-1ea9C:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 ILE C 136
VAL C 174
VAL C 189
ALA C 188
LEU C 181
None
1.01A 1vptA-1ea9C:
undetectable
1vptA-1ea9C:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 10 ALA C 391
PHE C 507
TYR C 519
PHE C 383
PHE C 384
None
1.22A 1y7iB-1ea9C:
undetectable
1y7iB-1ea9C:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 10 ALA C 391
SER C 395
PHE C 507
TYR C 519
PHE C 384
None
1.20A 1y7iB-1ea9C:
undetectable
1y7iB-1ea9C:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 6 LEU C 559
LEU C 529
LEU C 578
ILE C 528
None
0.96A 1z95A-1ea9C:
undetectable
1z95A-1ea9C:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 9 LEU C 184
LEU C 181
ILE C 233
ARG C 492
ILE C 491
None
1.27A 2f78A-1ea9C:
undetectable
2f78A-1ea9C:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 ARG C 336
GLU C 337
GLN C 367
None
1.01A 2p16A-1ea9C:
0.0
2p16A-1ea9C:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 GLN C 172
ILE C 136
ALA C 142
PHE C 141
LEU C 181
None
1.05A 2qb4A-1ea9C:
undetectable
2qb4A-1ea9C:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 11 GLN C 172
ILE C 136
ALA C 142
PHE C 141
LEU C 181
None
1.01A 2qjuA-1ea9C:
undetectable
2qjuA-1ea9C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 PHE C 338
ALA C 239
ARG C 323
TYR C 350
VAL C 128
None
1.36A 2rctA-1ea9C:
0.0
2rctA-1ea9C:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 8 LEU C 221
LEU C 171
CYH C 228
VAL C 174
ILE C 136
None
1.46A 2uxpA-1ea9C:
undetectable
2uxpA-1ea9C:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 8 ILE C 314
GLY C 321
LEU C 236
PHE C 241
None
0.79A 2vctA-1ea9C:
0.0
2vctA-1ea9C:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 8 ILE C 314
GLY C 321
LEU C 236
PHE C 241
None
0.82A 2vctB-1ea9C:
0.0
2vctB-1ea9C:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 8 ILE C 314
GLY C 321
LEU C 236
PHE C 241
None
0.85A 2vctC-1ea9C:
0.0
2vctC-1ea9C:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
6 / 12 ILE C 136
ALA C 239
ASP C 325
VAL C 189
LEU C 236
LEU C 352
None
1.27A 2yqzB-1ea9C:
undetectable
2yqzB-1ea9C:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 7 LEU C 236
TYR C 190
VAL C 490
ILE C 132
None
1.20A 3ik3A-1ea9C:
undetectable
3ik3A-1ea9C:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 SER C 359
SER C 360
HIS C 332
None
0.85A 3mzeA-1ea9C:
0.1
3mzeA-1ea9C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 5 PHE C 133
MET C 372
ASN C 373
PHE C 191
None
1.27A 3octA-1ea9C:
0.0
3octA-1ea9C:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 6 PHE C 191
LEU C 181
PHE C 141
LEU C 224
None
0.95A 3t3zA-1ea9C:
undetectable
3t3zA-1ea9C:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 LEU C  84
MET C  56
ASP C  66
None
0.73A 3v5wA-1ea9C:
undetectable
3v5wA-1ea9C:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 ASP C 482
LYS C 481
ASP C 480
None
0.60A 4a7tA-1ea9C:
2.5
4a7tA-1ea9C:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 LEU C 541
PHE C 384
VAL C 531
PHE C 383
GLN C 387
None
1.32A 4c9wA-1ea9C:
0.0
4c9wA-1ea9C:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 LYS C   1
ILE C  27
THR C  61
None
0.87A 4gh8A-1ea9C:
undetectable
4gh8A-1ea9C:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 VAL C 189
ALA C 188
TYR C 134
PHE C 141
PHE C 191
None
1.33A 4mm6A-1ea9C:
0.0
4mm6A-1ea9C:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 VAL C 186
ALA C 131
PHE C 444
LEU C 417
VAL C 490
None
1.33A 4nc3A-1ea9C:
undetectable
4nc3A-1ea9C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 GLY C 169
PHE C 191
LEU C 171
GLY C 173
VAL C 174
None
0.92A 4o3fA-1ea9C:
undetectable
4o3fA-1ea9C:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 ASN C 346
ASP C 320
ASP C 226
None
0.84A 4obwD-1ea9C:
undetectable
4obwD-1ea9C:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 ASP C 482
LEU C 483
PHE C 486
None
0.74A 4pthA-1ea9C:
undetectable
4pthA-1ea9C:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 6 SER C 419
GLY C 353
GLU C 354
ASP C 369
None
1.02A 4uckB-1ea9C:
undetectable
4uckB-1ea9C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 MET C 372
ASP C 238
PHE C 191
None
1.04A 4xeyA-1ea9C:
undetectable
4xeyA-1ea9C:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 MET C 372
ASP C 238
PHE C 191
None
1.07A 4xeyB-1ea9C:
0.0
4xeyB-1ea9C:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 10 LEU C 194
LEU C 171
LEU C 224
THR C 317
LEU C 237
None
1.04A 4z91A-1ea9C:
0.0
4z91B-1ea9C:
0.0
4z91C-1ea9C:
0.0
4z91D-1ea9C:
0.0
4z91E-1ea9C:
0.0
4z91A-1ea9C:
21.04
4z91B-1ea9C:
21.04
4z91C-1ea9C:
21.04
4z91D-1ea9C:
21.04
4z91E-1ea9C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
6 / 10 THR C 220
LEU C 171
LEU C 224
THR C 317
LEU C 237
LEU C 194
None
1.33A 4z91A-1ea9C:
0.0
4z91B-1ea9C:
0.0
4z91C-1ea9C:
0.0
4z91D-1ea9C:
0.0
4z91E-1ea9C:
0.0
4z91A-1ea9C:
21.04
4z91B-1ea9C:
21.04
4z91C-1ea9C:
21.04
4z91D-1ea9C:
21.04
4z91E-1ea9C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
3 / 3 VAL C 530
LEU C 425
MET C 436
None
0.85A 5ikrA-1ea9C:
0.0
5ikrA-1ea9C:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
5 / 12 LEU C 221
GLY C 144
GLY C 173
ASN C 148
GLY C 168
None
1.05A 5kb5A-1ea9C:
3.3
5kb5A-1ea9C:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)
1ea9 CYCLOMALTODEXTRINASE
(Bacillus
sp.
(in:
Bacteria))
4 / 7 HIS C 180
LEU C 460
TYR C 134
VAL C 458
None
1.25A 6g2pA-1ea9C:
undetectable
6g2pA-1ea9C:
20.79