SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.39A 1os2A-1eakA:
28.4		 1os2A-1eakA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.44A 1y93A-1eakA:
28.0		 1y93A-1eakA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		5 / 9 GLY A 418
LEU A 420
SER A 434
ASP A 436
ASP A 416
 None
 1.37A 2j2pB-1eakA:
0.0
2j2pC-1eakA:
0.0		 2j2pB-1eakA:
17.95
2j2pC-1eakA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.38A 2ow9A-1eakA:
28.0		 2ow9A-1eakA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		3 / 3 HIS A 403
HIS A 407
HIS A 413
 ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.35A 2ozrF-1eakA:
27.5		 2ozrF-1eakA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		5 / 12 PHE A 297
GLY A 318
LYS A 327
ASP A 326
THR A 320
 None
 1.33A 3a25A-1eakA:
undetectable		 3a25A-1eakA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		3 / 3 TYR A 445
GLU A 412
ASP A 106
 None
 0.85A 3bxoB-1eakA:
undetectable		 3bxoB-1eakA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		3 / 3 ASP A 249
LEU A 257
GLN A 219
 None
 0.82A 3g4lA-1eakA:
undetectable		 3g4lA-1eakA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		5 / 10 LEU A 157
GLN A 442
THR A 155
LEU A 411
GLY A 440
 None
 1.23A 3h9uA-1eakA:
undetectable		 3h9uA-1eakA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		5 / 9 LEU A 191
HIS A 403
HIS A 407
HIS A 413
ILE A 424
 None
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
None
 0.90A 3hy7A-1eakA:
10.2		 3hy7A-1eakA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		5 / 9 LEU A 191
HIS A 403
HIS A 407
HIS A 413
ILE A 424
 None
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
None
 0.60A 3hy7B-1eakA:
10.1		 3hy7B-1eakA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.39A 3likA-1eakA:
27.8		 3likA-1eakA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.42A 3lkaA-1eakA:
27.8		 3lkaA-1eakA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 6 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.35A 4a7bA-1eakA:
27.9		 4a7bA-1eakA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 5 GLN A 442
THR A 155
LEU A 420
LEU A 433
 None
 1.00A 4lvcB-1eakA:
undetectable		 4lvcB-1eakA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 7 HIS A 413
GLY A 103
ASN A 104
HIS A 403
 ZN  A 997 (-3.5A)
None
None
ZN  A 997 (-3.5A)
 1.38A 5a5zC-1eakA:
undetectable		 5a5zC-1eakA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 6 PHE A 389
PHE A 184
VAL A  41
ASP A 188
 None
 1.15A 5hesA-1eakA:
undetectable		 5hesA-1eakA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		4 / 4 GLN A 442
THR A 155
LEU A 420
LEU A 433
 None
 0.98A 5m5kB-1eakA:
undetectable		 5m5kB-1eakA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens) 		3 / 3 TYR A 182
HIS A 193
PHE A 195
 None
ZN  A 996 (-3.1A)
None
 0.26A 6esmA-1eakA:
27.6		 6esmA-1eakA:
33.33