SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.02A 1etb1-1eb3A:
undetectable		 1etb1-1eb3A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.07A 1ictB-1eb3A:
undetectable		 1ictB-1eb3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 335
PHE A  43
LEU A  45
GLU A 333
TYR A  74
 None
 1.21A 1kw0A-1eb3A:
undetectable		 1kw0A-1eb3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 335
PHE A  43
LEU A  45
GLU A 333
TYR A  74
 None
 1.08A 1mmkA-1eb3A:
undetectable		 1mmkA-1eb3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 335
PHE A  43
LEU A  45
GLU A 333
TYR A  74
 None
 1.09A 1mmtA-1eb3A:
undetectable		 1mmtA-1eb3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 5 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.13A 1tt6B-1eb3A:
undetectable		 1tt6B-1eb3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 171
ILE A 116
ASP A 106
ILE A 189
LEU A 193
 None
 1.12A 1tw4A-1eb3A:
undetectable		 1tw4A-1eb3A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 171
ILE A 116
ASP A 106
ILE A 189
LEU A 193
 None
 1.01A 2jn3A-1eb3A:
undetectable		 2jn3A-1eb3A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 249
ARG A 246
ALA A 248
ILE A 271
 None
 1.14A 2qhfA-1eb3A:
0.0		 2qhfA-1eb3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 4 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.00A 2roxA-1eb3A:
undetectable		 2roxA-1eb3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  91
PRO A  92
PRO A 111
VAL A 112
 None
 0.97A 2v32C-1eb3A:
undetectable
2v32D-1eb3A:
undetectable		 2v32C-1eb3A:
23.19
2v32D-1eb3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 194
LEU A 193
VAL A 204
GLY A 256
 None
 0.67A 2wd9A-1eb3A:
undetectable		 2wd9A-1eb3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 194
LEU A 193
VAL A 204
GLY A 256
 None
 0.66A 2wd9B-1eb3A:
2.1		 2wd9B-1eb3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.05A 4i89A-1eb3A:
undetectable		 4i89A-1eb3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  81
LEU A  78
ALA A  80
 None
 0.67A 4ikiA-1eb3A:
undetectable		 4ikiA-1eb3A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 249
ASP A 270
GLU A 277
ALA A 323
 None
 0.96A 4nkxA-1eb3A:
0.0		 4nkxA-1eb3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  45
ILE A  47
LEU A  71
TYR A  74
 None
 0.92A 4w5nA-1eb3A:
undetectable		 4w5nA-1eb3A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 185
ASP A 188
ARG A 187
 None
 0.63A 4wq4B-1eb3A:
0.4		 4wq4B-1eb3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 185
ASP A 180
TYR A 207
 None
None
DSB  A1341 ( 4.5A)
 0.94A 4yo9B-1eb3A:
0.0		 4yo9B-1eb3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 326
HIS A 315
LEU A  36
GLY A 317
 None
 1.04A 4z69A-1eb3A:
0.2		 4z69A-1eb3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 5 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.03A 5cr1A-1eb3A:
undetectable		 5cr1A-1eb3A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 314
HIS A 315
LEU A 296
LEU A 307
 None
 1.06A 5dzkd-1eb3A:
1.0
5dzkr-1eb3A:
undetectable		 5dzkd-1eb3A:
22.32
5dzkr-1eb3A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 314
HIS A 315
LEU A 296
LEU A 307
 None
 1.10A 5dzke-1eb3A:
0.8
5dzks-1eb3A:
undetectable		 5dzke-1eb3A:
22.32
5dzks-1eb3A:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 144
CYH A 133
CYH A 135
 None
ZN  A1342 (-2.2A)
ZN  A1342 (-2.2A)
 0.97A 5inzB-1eb3A:
undetectable		 5inzB-1eb3A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  83
ILE A  66
ILE A 128
LEU A  88
PHE A  43
 None
 0.93A 5mugA-1eb3A:
1.6		 5mugA-1eb3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 235
ASP A 149
THR A 151
HIS A 142
GLY A 230
 None
 1.30A 6mb5A-1eb3A:
0.7		 6mb5A-1eb3A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 235
ASP A 149
THR A 151
HIS A 142
GLY A 230
 None
 1.31A 6mb9A-1eb3A:
0.8		 6mb9A-1eb3A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 235
ASP A 149
THR A 151
HIS A 142
GLY A 230
 None
 1.30A 6mb9B-1eb3A:
0.9		 6mb9B-1eb3A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 235
ASP A 149
THR A 151
HIS A 142
GLY A 230
 None
 1.27A 6mb9C-1eb3A:
1.0		 6mb9C-1eb3A:
13.89