SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eb6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 11 ASN A  79
SER A  13
LEU A  14
ALA A  17
LEU A  18
 None
EDO  A1178 (-3.6A)
None
None
None
 1.26A 1hwkB-1eb6A:
undetectable		 1hwkB-1eb6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 11 ASN A  79
SER A  13
LEU A  14
ALA A  17
LEU A  18
 None
EDO  A1178 (-3.6A)
None
None
None
 1.24A 1hwkA-1eb6A:
undetectable		 1hwkA-1eb6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 11 ASN A  79
SER A  13
LEU A  14
ALA A  17
LEU A  18
 None
EDO  A1178 (-3.6A)
None
None
None
 1.25A 1hwkD-1eb6A:
0.0		 1hwkD-1eb6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 11 ASN A  79
SER A  13
LEU A  14
ALA A  17
LEU A  18
 None
EDO  A1178 (-3.6A)
None
None
None
 1.25A 1hwkC-1eb6A:
undetectable		 1hwkC-1eb6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 12 THR A 125
HIS A 128
GLU A 129
HIS A 132
TYR A 146
 None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
None
 0.59A 1j36A-1eb6A:
3.1		 1j36A-1eb6A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 12 THR A 125
HIS A 128
GLU A 129
HIS A 132
TYR A 146
 None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
None
 0.59A 1j36B-1eb6A:
3.1		 1j36B-1eb6A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 12 ALA A  91
HIS A 128
GLU A 129
HIS A 132
TYR A 146
 None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
None
 0.40A 2c6nA-1eb6A:
3.5		 2c6nA-1eb6A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		4 / 5 ARG A  52
PHE A  40
LEU A  59
ALA A  31
 None
 1.48A 2e1qD-1eb6A:
undetectable		 2e1qD-1eb6A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 9 LEU A  90
THR A 125
HIS A 128
GLU A 129
HIS A 132
 None
None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
 0.47A 2jihA-1eb6A:
4.9		 2jihA-1eb6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 8 LEU A  90
THR A 125
HIS A 128
GLU A 129
HIS A 132
 None
None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
 0.47A 2jihB-1eb6A:
4.6		 2jihB-1eb6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 9 LEU A  90
THR A 125
HIS A 128
GLU A 129
HIS A 132
 None
None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
 0.46A 3hy7A-1eb6A:
5.0		 3hy7A-1eb6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		5 / 9 LEU A  90
THR A 125
HIS A 128
GLU A 129
HIS A 132
 None
None
ZN  A 178 (-3.3A)
ZN  A 178 ( 4.0A)
ZN  A 178 (-3.3A)
 0.44A 3hy7B-1eb6A:
5.2		 3hy7B-1eb6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		3 / 3 ALA A  91
GLN A 122
THR A 125
 None
 0.59A 5n0oA-1eb6A:
0.0		 5n0oA-1eb6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		3 / 3 THR A 126
ALA A  21
LYS A  23
 None
 0.77A 6fgcA-1eb6A:
undetectable		 6fgcA-1eb6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1eb6 NEUTRAL PROTEASE II
(Aspergillus
oryzae) 		3 / 3 THR A 126
ALA A  21
LYS A  23
 None
 0.76A 6fgdA-1eb6A:
undetectable		 6fgdA-1eb6A:
19.15