SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ebb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A  97
TRP A  89
PHE A 108
GLU A  90
 None
SO4  A 304 ( 4.8A)
None
None
 1.47A 1nsiA-1ebbA:
0.0
1nsiB-1ebbA:
0.0		 1nsiA-1ebbA:
21.66
1nsiB-1ebbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  97
TRP A  89
PHE A 108
GLU A  90
 None
SO4  A 304 ( 4.8A)
None
None
 1.48A 2nsiA-1ebbA:
0.0
2nsiB-1ebbA:
0.2		 2nsiA-1ebbA:
21.66
2nsiB-1ebbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  89
PHE A 108
GLU A  90
ILE A  97
 SO4  A 304 ( 4.8A)
None
None
None
 1.49A 2nsiA-1ebbA:
0.0
2nsiB-1ebbA:
0.2		 2nsiA-1ebbA:
21.66
2nsiB-1ebbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  97
TRP A  89
PHE A 108
GLU A  90
 None
SO4  A 304 ( 4.8A)
None
None
 1.50A 2nsiC-1ebbA:
0.0
2nsiD-1ebbA:
0.0		 2nsiC-1ebbA:
21.66
2nsiD-1ebbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  97
TRP A  89
PHE A 108
GLU A  90
 None
SO4  A 304 ( 4.8A)
None
None
 1.49A 3e7gA-1ebbA:
0.0
3e7gB-1ebbA:
0.0		 3e7gA-1ebbA:
21.03
3e7gB-1ebbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  89
PHE A 108
GLU A  90
ILE A  97
 SO4  A 304 ( 4.8A)
None
None
None
 1.48A 3e7gA-1ebbA:
0.0
3e7gB-1ebbA:
0.0		 3e7gA-1ebbA:
21.03
3e7gB-1ebbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A   8
VAL A 181
VAL A 134
ILE A 137
THR A   3
 None
 1.48A 3em0A-1ebbA:
0.2		 3em0A-1ebbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 123
PHE A 108
TYR A 115
VAL A 126
 None
 1.30A 3lb3A-1ebbA:
undetectable		 3lb3A-1ebbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 130
LEU A   7
LEU A  81
ASP A  78
ILE A 148
 None
 1.14A 3wdmD-1ebbA:
undetectable		 3wdmD-1ebbA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 7 TRP A  89
PHE A 108
GLU A  90
ILE A  97
 SO4  A 304 ( 4.8A)
None
None
None
 1.44A 4nosA-1ebbA:
0.3
4nosB-1ebbA:
0.0		 4nosA-1ebbA:
20.79
4nosB-1ebbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A  97
TRP A  89
PHE A 108
GLU A  90
 None
SO4  A 304 ( 4.8A)
None
None
 1.49A 4nosC-1ebbA:
0.0
4nosD-1ebbA:
0.2		 4nosC-1ebbA:
20.79
4nosD-1ebbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A  23
GLN A  22
SER A  55
HIS A 151
 GOL  A 402 (-3.7A)
GOL  A 400 ( 3.8A)
None
GOL  A 400 ( 4.6A)
 0.92A 4wryA-1ebbA:
undetectable		 4wryA-1ebbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 1ebb PHOSPHATASE
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 192
ILE A 183
ILE A 184
TYR A   6
 None
None
None
SO4  A 303 (-4.3A)
 1.27A 5dnvA-1ebbA:
undetectable		 5dnvA-1ebbA:
21.51