SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ebd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 107
ALA A  29
ILE A 144
VAL A 112
 None
 0.78A 1d4sB-1ebdA:
0.0		 1d4sB-1ebdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 313
ALA A 325
SER A 326
ASP A 314
ILE A 315
 FAD  A 462 (-3.4A)
FAD  A 462 ( 3.7A)
None
FAD  A 462 (-2.8A)
None
 1.16A 1nt2A-1ebdA:
1.7		 1nt2A-1ebdA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.79A 1rxcB-1ebdA:
undetectable		 1rxcB-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 7 GLY A 427
ILE A 423
VAL A 361
PRO A 349
 None
 1.07A 1rxcD-1ebdA:
undetectable		 1rxcD-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.81A 1rxcE-1ebdA:
undetectable		 1rxcE-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.83A 1rxcI-1ebdA:
undetectable		 1rxcI-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.82A 1rxcK-1ebdA:
undetectable		 1rxcK-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 ALA A 208
ILE A 211
GLY A 184
GLY A 183
ILE A 182
 None
 1.22A 1sguA-1ebdA:
undetectable		 1sguA-1ebdA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 ILE A 189
GLY A 184
GLY A 183
ILE A 182
ALA A 169
 None
 1.21A 1sguA-1ebdA:
undetectable		 1sguA-1ebdA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 ILE A 211
GLY A 184
GLY A 183
ILE A 182
ALA A 256
 None
 1.29A 1sguA-1ebdA:
undetectable		 1sguA-1ebdA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 11 LEU A 179
GLY A 188
VAL A 232
ILE A  59
THR A 200
VAL A 202
 None
 1.07A 1t7jA-1ebdA:
undetectable		 1t7jA-1ebdA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 170
GLY A 168
LEU A 191
PRO A 176
 None
 0.85A 1ya4B-1ebdA:
1.9		 1ya4B-1ebdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 ALA A 359
ALA A 453
ALA A 456
GLN A 413
 None
 0.92A 2nyrB-1ebdA:
3.5		 2nyrB-1ebdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 325
GLY A  16
LYS A  40
GLU A 118
LEU A 281
 FAD  A 462 ( 3.7A)
FAD  A 462 (-3.4A)
FAD  A 462 (-4.1A)
None
None
 0.78A 2plwA-1ebdA:
3.2		 2plwA-1ebdA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A 357
PRO A 356
ILE A 415
GLY A 416
 None
 1.19A 2qeuA-1ebdA:
undetectable
2qeuC-1ebdA:
0.1		 2qeuA-1ebdA:
13.41
2qeuC-1ebdA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 427
GLU A 431
ILE A 409
ALA A 412
 None
 0.77A 3aodA-1ebdA:
0.0		 3aodA-1ebdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 ASN A 197
ALA A 194
GLY A 192
TYR A 195
 None
 1.21A 3bcrA-1ebdA:
undetectable		 3bcrA-1ebdA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 457
ALA A 456
ALA A 440
VAL A 361
ILE A 423
 None
 1.01A 3falA-1ebdA:
undetectable		 3falA-1ebdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 304
ASP A 123
VAL A 127
TYR A 120
ASN A 308
 None
 1.48A 3hiiB-1ebdA:
undetectable		 3hiiB-1ebdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 TYR A 138
VAL A 129
VAL A  15
ASN A 131
GLY A 117
 None
 1.27A 3km6A-1ebdA:
undetectable		 3km6A-1ebdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 TYR A 138
VAL A 129
VAL A  15
ASN A 131
GLY A 117
 None
 1.27A 3km6B-1ebdA:
0.0		 3km6B-1ebdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 TYR A 138
VAL A 129
VAL A  15
ASN A 131
GLY A 117
 None
 1.30A 3kmoA-1ebdA:
0.0		 3kmoA-1ebdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 138
VAL A 129
ASN A 131
GLY A 117
 None
 0.97A 3kmoB-1ebdA:
undetectable		 3kmoB-1ebdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 179
VAL A 232
ILE A  59
THR A 200
VAL A 202
 None
 0.95A 3so9B-1ebdA:
undetectable		 3so9B-1ebdA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 ILE A 182
PHE A 157
GLU A 255
THR A 260
VAL A 235
 None
 1.41A 3ua5A-1ebdA:
0.0		 3ua5A-1ebdA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 GLY A 183
GLY A 184
GLY A 192
LEU A 227
VAL A 202
 None
 1.22A 3v1nA-1ebdA:
undetectable		 3v1nA-1ebdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 192
ALA A 194
ASN A 197
ILE A 204
ILE A 211
 None
 0.85A 4ax8A-1ebdA:
4.6		 4ax8A-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 192
ALA A 194
ASN A 197
ILE A 204
ILE A 211
 None
 0.87A 4aztA-1ebdA:
4.1		 4aztA-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 192
ALA A 194
ASN A 197
ILE A 204
ILE A 211
 None
 0.85A 4azvA-1ebdA:
3.7		 4azvA-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A 325
ILE A 312
LYS A 324
ILE A 145
ILE A 315
 FAD  A 462 ( 3.7A)
None
None
None
None
 1.19A 4dtaA-1ebdA:
undetectable		 4dtaA-1ebdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.80A 4e1vA-1ebdA:
undetectable		 4e1vA-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.79A 4e1vC-1ebdA:
undetectable		 4e1vC-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.82A 4e1vD-1ebdA:
undetectable		 4e1vD-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.81A 4e1vE-1ebdA:
undetectable		 4e1vE-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.79A 4e1vG-1ebdA:
undetectable		 4e1vG-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 147
GLY A 313
ILE A 315
VAL A 316
 FAD  A 462 (-4.0A)
FAD  A 462 (-3.4A)
None
None
 0.81A 4e1vH-1ebdA:
undetectable		 4e1vH-1ebdA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 200
PRO A 176
ILE A 182
VAL A 252
ILE A 263
 None
 1.46A 4eb6B-1ebdA:
undetectable
4eb6C-1ebdA:
undetectable		 4eb6B-1ebdA:
21.05
4eb6C-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 278
ILE A 296
VAL A 298
GLY A 313
 None
None
None
FAD  A 462 (-3.4A)
 0.79A 4eq4B-1ebdA:
undetectable		 4eq4B-1ebdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  58
LYS A  56
LEU A 191
GLU A 190
 None
FAD  A 462 (-3.4A)
None
None
 1.19A 4f3tA-1ebdA:
undetectable		 4f3tA-1ebdA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 179
GLY A 188
VAL A 232
ILE A  59
THR A 200
 None
 1.00A 4njtD-1ebdA:
undetectable		 4njtD-1ebdA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A 429
ILE A 376
GLY A 411
ALA A 412
ALA A 456
ILE A 439
 None
 1.36A 4nkxB-1ebdA:
0.0		 4nkxB-1ebdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 103
ILE A  37
GLY A  21
ALA A  17
LEU A  48
 None
 0.97A 4o1zA-1ebdA:
0.0		 4o1zA-1ebdA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 263
VAL A 180
ILE A 182
VAL A 252
 None
 0.70A 4xdtA-1ebdA:
0.0		 4xdtA-1ebdA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 170
PRO A  54
LEU A 191
GLU A 190
 None
 1.07A 4z4fA-1ebdA:
undetectable		 4z4fA-1ebdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 ALA A 146
VAL A  14
GLY A  20
ALA A 325
GLY A 329
 FAD  A 462 (-4.7A)
None
FAD  A 462 (-3.7A)
FAD  A 462 ( 3.7A)
None
 1.28A 4zjzB-1ebdA:
2.2		 4zjzB-1ebdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 281
ALA A 119
VAL A 129
GLU A  39
LYS A  40
 None
FAD  A 462 (-4.0A)
None
FAD  A 462 (-2.5A)
FAD  A 462 (-4.1A)
 1.39A 5dbyA-1ebdA:
undetectable		 5dbyA-1ebdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A  24
GLU A 328
ALA A  17
GLY A  18
ALA A 146
 None
None
None
FAD  A 462 (-3.3A)
FAD  A 462 (-4.7A)
 1.18A 5lf3H-1ebdA:
2.9
5lf3I-1ebdA:
undetectable		 5lf3H-1ebdA:
20.57
5lf3I-1ebdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A 204
ILE A 189
VAL A 202
ASN A 197
GLU A  66
 None
 1.29A 5lg3F-1ebdA:
0.0		 5lg3F-1ebdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A  14
ILE A  37
LEU A 107
GLY A  20
ALA A 146
 None
None
None
FAD  A 462 (-3.7A)
FAD  A 462 (-4.7A)
 1.05A 5mxbA-1ebdA:
undetectable		 5mxbA-1ebdA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 212
GLY A 184
GLY A 183
VAL A 181
CYH A 358
 None
 1.07A 5uc1A-1ebdA:
undetectable		 5uc1A-1ebdA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 212
GLY A 184
GLY A 183
VAL A 181
CYH A 358
 None
 1.06A 5uc1B-1ebdA:
undetectable		 5uc1B-1ebdA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A  15
GLY A  16
GLU A  39
LYS A  40
ALA A 119
 None
FAD  A 462 (-3.4A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.1A)
FAD  A 462 (-4.0A)
 0.67A 5x6yA-1ebdA:
undetectable		 5x6yA-1ebdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 10 VAL A  15
GLY A  16
GLU A  39
LYS A  40
ALA A 119
ASN A 277
 None
FAD  A 462 (-3.4A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.1A)
FAD  A 462 (-4.0A)
None
 0.72A 5x6yB-1ebdA:
2.7		 5x6yB-1ebdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 11 VAL A  15
GLY A  16
GLU A  39
LYS A  40
ALA A 119
ASN A 277
 None
FAD  A 462 (-3.4A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.1A)
FAD  A 462 (-4.0A)
None
 0.86A 5x6yC-1ebdA:
undetectable		 5x6yC-1ebdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 GLY A  16
GLY A  18
GLU A  39
THR A 147
ASN A 277
 FAD  A 462 (-3.4A)
FAD  A 462 (-3.3A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.0A)
None
 0.90A 6exiA-1ebdA:
3.6		 6exiA-1ebdA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 GLY A  16
GLY A  18
GLU A  39
THR A 147
ASN A 277
 FAD  A 462 (-3.4A)
FAD  A 462 (-3.3A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.0A)
None
 0.93A 6exiB-1ebdA:
3.3		 6exiB-1ebdA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  16
GLY A  18
GLU A  39
THR A 147
ASN A 277
 FAD  A 462 (-3.4A)
FAD  A 462 (-3.3A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.0A)
None
 0.93A 6exiC-1ebdA:
4.1
6exiD-1ebdA:
4.5		 6exiC-1ebdA:
11.26
6exiD-1ebdA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  16
GLY A  18
GLU A  39
THR A 147
ASN A 277
 FAD  A 462 (-3.4A)
FAD  A 462 (-3.3A)
FAD  A 462 (-2.5A)
FAD  A 462 (-4.0A)
None
 0.90A 6exiC-1ebdA:
4.1
6exiD-1ebdA:
4.5		 6exiC-1ebdA:
11.26
6exiD-1ebdA:
11.26