SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ebv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.31A 1cqeA-1ebvA:
63.1		 1cqeA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.31A 1cqeB-1ebvA:
63.0		 1cqeB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 9 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
ILE A 523
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
SCL  A 700 (-3.4A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.40A 1eqgA-1ebvA:
63.6		 1eqgA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 11 VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 359
TYR A 385
ILE A 523
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 (-3.4A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 1eqgB-1ebvA:
63.6		 1eqgB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.34A 1eqhA-1ebvA:
63.7		 1eqhA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.35A 1eqhB-1ebvA:
63.7		 1eqhB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 LEU A 177
LEU A 182
ILE A 188
LEU A 491
LEU A 494
 None
 1.15A 1errB-1ebvA:
undetectable		 1errB-1ebvA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 10 VAL A 116
ARG A 120
PHE A 205
VAL A 228
VAL A 344
TYR A 348
VAL A 349
ASN A 375
ILE A 523
LEU A 531
 None
SCL  A 700 (-3.9A)
OAS  A 530 ( 4.7A)
None
None
None
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-3.4A)
OAS  A 530 (-4.1A)
 0.30A 1fe2A-1ebvA:
61.4		 1fe2A-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 10 VAL A 116
ARG A 120
PHE A 209
ILE A 523
LEU A 531
 None
SCL  A 700 (-3.9A)
None
SCL  A 700 (-3.4A)
OAS  A 530 (-4.1A)
 1.19A 1fe2A-1ebvA:
61.4		 1fe2A-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
PHE A 518
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.34A 1fe2A-1ebvA:
61.4		 1fe2A-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 PHE A 210
LEU A 352
TYR A 355
PHE A 381
PHE A 518
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.46A 1fe2A-1ebvA:
61.4		 1fe2A-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 6 TRP A 387
HIS A 386
LEU A 508
PRO A 505
 None
HEM  A 601 (-3.8A)
None
None
 1.27A 1hz4A-1ebvA:
0.0		 1hz4A-1ebvA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 PHE A 205
PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.39A 1igxA-1ebvA:
61.2		 1igxA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 PHE A 210
LEU A 352
TYR A 355
PHE A 381
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.48A 1igxA-1ebvA:
61.2		 1igxA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 8 VAL A 116
ARG A 120
VAL A 344
TYR A 348
VAL A 349
SER A 353
ILE A 523
LEU A 531
 None
SCL  A 700 (-3.9A)
None
None
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-3.4A)
OAS  A 530 (-4.1A)
 0.45A 1igxA-1ebvA:
61.2		 1igxA-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 8 ARG A 467
GLY A 483
GLU A 510
GLU A 520
 None
 0.88A 1pk7B-1ebvA:
undetectable		 1pk7B-1ebvA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 7 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 1pthA-1ebvA:
63.0		 1pthA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 7 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.35A 1pthB-1ebvA:
63.0		 1pthB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 10 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.47A 1pxxA-1ebvA:
31.2		 1pxxA-1ebvA:
63.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 9 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.40A 1pxxB-1ebvA:
58.1		 1pxxB-1ebvA:
63.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.43A 1pxxC-1ebvA:
30.8		 1pxxC-1ebvA:
63.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 10 VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.38A 1pxxD-1ebvA:
31.3		 1pxxD-1ebvA:
63.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 8 ASP A 158
TYR A  39
ASP A 135
THR A 161
 None
 0.97A 1rmtD-1ebvA:
undetectable		 1rmtD-1ebvA:
15.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
PHE A 518
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.40A 2aylA-1ebvA:
63.4		 2aylA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.35A 2aylB-1ebvA:
63.1		 2aylB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 6 VAL A 568
LEU A 300
PHE A 201
HIS A 204
 None
 1.29A 2f8dA-1ebvA:
0.0		 2f8dA-1ebvA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 11 TYR A 466
LEU A 460
LEU A 458
PRO A 125
LEU A 507
 None
 1.35A 2ft9A-1ebvA:
0.0		 2ft9A-1ebvA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 5 LEU A 534
GLY A 227
ILE A 337
ILE A 341
 OAS  A 530 ( 3.3A)
None
None
None
 0.81A 2q9rA-1ebvA:
0.0		 2q9rA-1ebvA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 7 PHE A 200
PHE A 395
ILE A 444
GLY A 293
 None
None
HEM  A 601 (-4.3A)
None
 1.02A 2v0mC-1ebvA:
0.0		 2v0mC-1ebvA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 9 PHE A 478
PRO A 172
LEU A 177
LEU A 494
PHE A 181
 None
 1.10A 2vcvD-1ebvA:
0.3		 2vcvD-1ebvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 9 PHE A 478
PRO A 172
LEU A 177
LEU A 494
PHE A 181
 None
 1.13A 2vcvE-1ebvA:
0.0		 2vcvE-1ebvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 9 PHE A 478
PRO A 172
LEU A 177
LEU A 494
PHE A 181
 None
 1.16A 2vcvH-1ebvA:
undetectable		 2vcvH-1ebvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 9 PHE A 478
PRO A 172
LEU A 177
LEU A 494
PHE A 181
 None
 1.20A 2vcvI-1ebvA:
undetectable		 2vcvI-1ebvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 7 TYR A 348
LEU A 534
LYS A 531
TYR A 385
 None
OAS  A 530 ( 3.3A)
OAS  A 530 (-3.0A)
None
 1.30A 2w98A-1ebvA:
undetectable
2w98B-1ebvA:
undetectable		 2w98A-1ebvA:
21.90
2w98B-1ebvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 PHE A 209
PHE A 198
LEU A 390
HIS A 386
TYR A 348
 None
None
HEM  A 601 ( 4.7A)
HEM  A 601 (-3.8A)
None
 1.22A 3apvB-1ebvA:
0.0		 3apvB-1ebvA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 7 LEU A 390
ARG A 433
GLY A 519
MET A 522
 HEM  A 601 ( 4.7A)
None
None
None
 1.09A 3hcrB-1ebvA:
undetectable		 3hcrB-1ebvA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 VAL A 116
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 534
 None
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
 0.50A 3hs6A-1ebvA:
57.8		 3hs6A-1ebvA:
63.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 PHE A 209
GLY A 227
TYR A 355
ASN A 375
ILE A 377
PHE A 381
TYR A 385
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 None
None
SCL  A 700 (-4.3A)
None
None
OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.38A 3hs6B-1ebvA:
30.3		 3hs6B-1ebvA:
63.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 (-4.3A)
None
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.34A 3hs6B-1ebvA:
30.3		 3hs6B-1ebvA:
63.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 7 PHE A 205
VAL A 344
VAL A 349
LEU A 352
SER A 353
TRP A 387
 OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
 0.31A 3hs6B-1ebvA:
30.3		 3hs6B-1ebvA:
63.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 GLN A 192
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TRP A 387
SER A 516
PHE A 518
ILE A 523
GLY A 526
ALA A 527
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.51A 3kk6A-1ebvA:
59.7		 3kk6A-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 6 HIS A  90
SER A 353
LEU A 507
ILE A 517
 None
 0.87A 3kk6A-1ebvA:
59.7		 3kk6A-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 6 HIS A  90
VAL A 116
SER A 353
LEU A 384
ILE A 517
LEU A 531
 None
None
None
None
None
OAS  A 530 (-4.1A)
 0.45A 3kk6A-1ebvA:
59.7		 3kk6A-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TRP A 387
SER A 516
PHE A 518
ILE A 523
GLY A 526
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
 0.53A 3kk6B-1ebvA:
59.6		 3kk6B-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 HIS A 513
VAL A 349
LEU A 352
TRP A 387
ILE A 523
GLY A 526
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
 1.46A 3kk6B-1ebvA:
59.6		 3kk6B-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 6 VAL A 116
SER A 353
LEU A 384
ILE A 517
ALA A 527
LEU A 531
 None
None
None
None
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.48A 3kk6B-1ebvA:
59.6		 3kk6B-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 HIS A 204
PHE A 198
PHE A 580
 None
 0.64A 3lk0D-1ebvA:
0.0		 3lk0D-1ebvA:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.31A 3ln1A-1ebvA:
58.3		 3ln1A-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 8 ARG A 120
LEU A 352
SER A 353
LEU A 384
TYR A 385
ILE A 517
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
None
None
None
None
 0.46A 3ln1A-1ebvA:
58.3		 3ln1A-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 8 LEU A 352
SER A 353
LEU A 384
TYR A 385
ILE A 517
PHE A 518
 SCL  A 700 ( 4.8A)
None
None
None
None
None
 0.78A 3ln1A-1ebvA:
58.3		 3ln1A-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.29A 3ln1B-1ebvA:
58.3		 3ln1B-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 7 ARG A 120
LEU A 352
SER A 353
LEU A 384
ILE A 517
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
None
None
None
 0.50A 3ln1B-1ebvA:
58.3		 3ln1B-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 7 LEU A 352
SER A 353
LEU A 384
ILE A 517
PHE A 518
 SCL  A 700 ( 4.8A)
None
None
None
None
 0.82A 3ln1B-1ebvA:
58.3		 3ln1B-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 7 LEU A 352
SER A 353
LEU A 507
ILE A 517
PHE A 518
 SCL  A 700 ( 4.8A)
None
None
None
None
 1.14A 3ln1B-1ebvA:
58.3		 3ln1B-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 HIS A  90
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.32A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 7 ARG A 120
GLN A 192
SER A 353
LEU A 384
ILE A 517
 SCL  A 700 (-3.9A)
None
None
None
None
 0.44A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 7 GLN A 192
SER A 353
LEU A 384
ILE A 517
PHE A 518
 None
 0.79A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 7 GLN A 192
SER A 353
LEU A 507
ILE A 517
PHE A 518
 None
 1.21A 3ln1C-1ebvA:
58.3		 3ln1C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 HIS A  90
GLN A 192
VAL A 349
SER A 353
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.30A 3ln1D-1ebvA:
30.7		 3ln1D-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 ASP A 135
SER A 154
ARG A 157
 None
 1.02A 3loqA-1ebvA:
undetectable		 3loqA-1ebvA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.37A 3n8wA-1ebvA:
62.2		 3n8wA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 HIS A  90
ARG A 120
LEU A 352
TYR A 355
TYR A 385
TRP A 387
PHE A 518
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.45A 3n8xA-1ebvA:
61.6		 3n8xA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 HIS A 513
LEU A 352
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
 None
SCL  A 700 ( 4.8A)
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.27A 3n8xA-1ebvA:
61.6		 3n8xA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 VAL A 349
SER A 353
LEU A 359
 SCL  A 700 ( 4.6A)
None
None
 0.25A 3n8xA-1ebvA:
61.6		 3n8xA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 HIS A  90
ARG A 120
LEU A 352
TYR A 355
LEU A 359
TRP A 387
PHE A 518
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.40A 3n8xB-1ebvA:
61.5		 3n8xB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 HIS A 513
LEU A 352
TRP A 387
ILE A 523
GLY A 526
ALA A 527
 None
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.35A 3n8xB-1ebvA:
61.5		 3n8xB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 VAL A 116
VAL A 349
SER A 353
 None
SCL  A 700 ( 4.6A)
None
 0.28A 3n8xB-1ebvA:
61.5		 3n8xB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 11 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.57A 3n8yA-1ebvA:
61.9		 3n8yA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		12 / 12 VAL A 344
VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
LEU A 534
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
OAS  A 530 ( 3.3A)
 0.46A 3n8yB-1ebvA:
61.4		 3n8yB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 5 VAL A 349
LEU A 352
TYR A 355
ILE A 523
ALA A 527
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
SCL  A 700 (-3.4A)
SCL  A 700 (-2.9A)
 0.46A 3n8yB-1ebvA:
61.4		 3n8yB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.35A 3n8zA-1ebvA:
61.5		 3n8zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.37A 3n8zB-1ebvA:
62.0		 3n8zB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.58A 3nt1A-1ebvA:
30.6		 3nt1A-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.58A 3nt1B-1ebvA:
58.6		 3nt1B-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 116
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.42A 3pghA-1ebvA:
23.5		 3pghA-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 11 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
MET A 522
GLY A 526
ALA A 527
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.45A 3pghB-1ebvA:
21.7		 3pghB-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 116
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.42A 3pghC-1ebvA:
25.5		 3pghC-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.45A 3pghD-1ebvA:
23.3		 3pghD-1ebvA:
64.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 8 PHE A 181
ILE A 452
TYR A 495
LEU A 494
 None
 1.02A 3rqwI-1ebvA:
0.0
3rqwJ-1ebvA:
0.0		 3rqwI-1ebvA:
19.20
3rqwJ-1ebvA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.40A 3rr3A-1ebvA:
31.6		 3rr3A-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.40A 3rr3B-1ebvA:
31.2		 3rr3B-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.57A 3rr3C-1ebvA:
58.5		 3rr3C-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.57A 3rr3D-1ebvA:
30.9		 3rr3D-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 9 LEU A 334
GLY A 225
PRO A 538
ILE A 539
ILE A 337
 None
 1.12A 3s56B-1ebvA:
undetectable		 3s56B-1ebvA:
11.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.44A 4coxA-1ebvA:
22.3		 4coxA-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 ARG A 120
VAL A 349
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.69A 4coxA-1ebvA:
22.3		 4coxA-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.70A 4coxB-1ebvA:
57.9		 4coxB-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.43A 4coxB-1ebvA:
57.9		 4coxB-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.44A 4coxC-1ebvA:
14.9		 4coxC-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.70A 4coxD-1ebvA:
30.8		 4coxD-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.43A 4coxD-1ebvA:
30.8		 4coxD-1ebvA:
64.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 PHE A 205
PHE A 209
TYR A 355
ASN A 375
ILE A 377
PHE A 381
TYR A 385
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 OAS  A 530 ( 4.7A)
None
SCL  A 700 (-4.3A)
None
None
OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.33A 4e1gA-1ebvA:
58.5		 4e1gA-1ebvA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 (-4.3A)
None
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.29A 4e1gA-1ebvA:
58.5		 4e1gA-1ebvA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 5 ARG A 120
VAL A 349
LEU A 352
SER A 353
MET A 522
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
 0.38A 4e1gA-1ebvA:
58.5		 4e1gA-1ebvA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 ARG A 120
PHE A 205
PHE A 209
TYR A 355
ILE A 377
PHE A 381
TYR A 385
GLY A 526
ALA A 527
GLY A 533
LEU A 534
 SCL  A 700 (-3.9A)
OAS  A 530 ( 4.7A)
None
SCL  A 700 (-4.3A)
None
OAS  A 530 ( 4.7A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 4.0A)
OAS  A 530 ( 3.3A)
 0.41A 4e1gB-1ebvA:
58.5		 4e1gB-1ebvA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 HEM  A 601 (-4.7A)
SCL  A 700 (-4.3A)
None
OAS  A 530 ( 4.7A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.32A 4e1gB-1ebvA:
58.5		 4e1gB-1ebvA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 7 VAL A 344
TYR A 348
VAL A 349
LEU A 352
ASN A 375
MET A 522
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
 0.31A 4e1gB-1ebvA:
58.5		 4e1gB-1ebvA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 ARG A 120
ILE A 345
LEU A 352
LEU A 359
TRP A 387
MET A 522
ALA A 527
 SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.8A)
None
None
None
SCL  A 700 (-2.9A)
 0.64A 4m11A-1ebvA:
57.9		 4m11A-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 12 MET A 113
ARG A 120
ILE A 345
VAL A 349
LEU A 359
TRP A 387
MET A 522
ALA A 527
 None
SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.6A)
None
None
None
SCL  A 700 (-2.9A)
 0.51A 4m11A-1ebvA:
57.9		 4m11A-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 MET A 113
LEU A 117
ARG A 120
ILE A 345
LEU A 359
MET A 522
ALA A 527
 None
None
SCL  A 700 (-3.9A)
None
None
None
SCL  A 700 (-2.9A)
 0.66A 4m11A-1ebvA:
57.9		 4m11A-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 MET A 113
VAL A 116
ARG A 120
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
ALA A 527
LEU A 534
 None
None
SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
 0.74A 4m11B-1ebvA:
57.9		 4m11B-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 MET A 113
VAL A 116
ARG A 120
LEU A 352
ALA A 527
LEU A 531
LEU A 534
 None
None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
OAS  A 530 ( 3.3A)
 1.24A 4m11B-1ebvA:
57.9		 4m11B-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 ILE A 345
LEU A 352
LEU A 359
TRP A 387
ALA A 527
LEU A 534
 None
SCL  A 700 ( 4.8A)
None
None
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
 0.64A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 MET A 113
ILE A 345
VAL A 349
LEU A 359
TRP A 387
ALA A 527
LEU A 534
 None
None
SCL  A 700 ( 4.6A)
None
None
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
 0.48A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 MET A 113
VAL A 116
ILE A 345
VAL A 349
LEU A 359
TRP A 387
LEU A 534
 None
None
None
SCL  A 700 ( 4.6A)
None
None
OAS  A 530 ( 3.3A)
 0.62A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 LEU A 117
ARG A 120
MET A 522
 None
SCL  A 700 (-3.9A)
None
 0.68A 4m11C-1ebvA:
33.5		 4m11C-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 ARG A 120
ILE A 345
LEU A 352
LEU A 359
TRP A 387
ALA A 527
 SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.8A)
None
None
SCL  A 700 (-2.9A)
 0.66A 4m11D-1ebvA:
57.9		 4m11D-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 MET A 113
ARG A 120
ILE A 345
VAL A 349
LEU A 359
TRP A 387
ALA A 527
 None
SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.6A)
None
None
SCL  A 700 (-2.9A)
 0.49A 4m11D-1ebvA:
57.9		 4m11D-1ebvA:
64.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 MET A 113
VAL A 116
ILE A 345
VAL A 349
LEU A 359
TRP A 387
ALA A 527
 None
None
None
SCL  A 700 ( 4.6A)
None
None
SCL  A 700 (-2.9A)
 0.62A 4m11D-1ebvA:
57.9		 4m11D-1ebvA:
64.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 5 GLY A 496
ASP A 497
GLU A 502
VAL A 155
 None
 0.96A 4nkvD-1ebvA:
0.0		 4nkvD-1ebvA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 ILE A 345
VAL A 349
LEU A 352
TRP A 387
GLY A 526
ALA A 527
LEU A 117
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
None
 1.29A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 MET A 113
ILE A 345
VAL A 349
LEU A 352
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 534
LEU A 535
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 ( 3.3A)
None
 0.56A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 MET A 113
ILE A 523
GLY A 526
ALA A 527
LEU A 531
LEU A 534
LEU A 535
 None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
OAS  A 530 ( 3.3A)
None
 1.07A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 6 VAL A 116
LEU A 117
ARG A 120
LEU A 359
PHE A 518
MET A 522
 None
None
SCL  A 700 (-3.9A)
None
None
None
 0.49A 4o1zA-1ebvA:
62.2		 4o1zA-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 12 MET A 113
VAL A 116
LEU A 117
ARG A 120
ALA A 527
LEU A 531
 None
None
None
SCL  A 700 (-3.9A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.92A 4o1zB-1ebvA:
62.4		 4o1zB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 MET A 113
VAL A 116
LEU A 117
ARG A 120
ILE A 345
VAL A 349
LEU A 359
TRP A 387
PHE A 518
ALA A 527
 None
None
None
SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.6A)
None
None
None
SCL  A 700 (-2.9A)
 0.57A 4o1zB-1ebvA:
62.4		 4o1zB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.65A 4otyA-1ebvA:
30.7		 4otyA-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.39A 4otyA-1ebvA:
30.7		 4otyA-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.62A 4otyB-1ebvA:
30.6		 4otyB-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.35A 4otyB-1ebvA:
30.6		 4otyB-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 LEU A 534
ASN A 537
GLY A 536
GLN A 208
ILE A 337
 OAS  A 530 ( 3.3A)
None
None
None
None
 1.15A 4p6xI-1ebvA:
undetectable		 4p6xI-1ebvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 ILE A 304
THR A 303
THR A 572
LEU A 300
LEU A 414
 None
 0.89A 4pbhA-1ebvA:
0.0		 4pbhA-1ebvA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 10 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.39A 4ph9A-1ebvA:
58.8		 4ph9A-1ebvA:
64.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 10 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.34A 4ph9B-1ebvA:
58.8		 4ph9B-1ebvA:
64.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.56A 4rrwA-1ebvA:
58.1		 4rrwA-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.55A 4rrwB-1ebvA:
32.7		 4rrwB-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.55A 4rrwC-1ebvA:
58.1		 4rrwC-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 VAL A 349
SER A 353
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.64A 4rrwC-1ebvA:
58.1		 4rrwC-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.79A 4rrwD-1ebvA:
58.1		 4rrwD-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 4rrwD-1ebvA:
58.1		 4rrwD-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 TYR A 348
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.67A 4rrxA-1ebvA:
57.7		 4rrxA-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 TYR A 348
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.67A 4rrxB-1ebvA:
32.4		 4rrxB-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.56A 4rrzA-1ebvA:
58.1		 4rrzA-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.55A 4rrzB-1ebvA:
32.7		 4rrzB-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.55A 4rrzC-1ebvA:
58.1		 4rrzC-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		7 / 12 VAL A 349
SER A 353
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.64A 4rrzC-1ebvA:
58.1		 4rrzC-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.79A 4rrzD-1ebvA:
58.1		 4rrzD-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 4rrzD-1ebvA:
58.1		 4rrzD-1ebvA:
64.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 9 ARG A 120
VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 359
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.38A 4rs0A-1ebvA:
33.8		 4rs0A-1ebvA:
64.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 LEU A 230
ILE A 337
GLY A 338
VAL A 344
LEU A 534
 None
None
None
None
OAS  A 530 ( 3.3A)
 1.10A 4y8wA-1ebvA:
0.0		 4y8wA-1ebvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 5 PHE A 470
ILE A 124
GLY A 526
ILE A 151
 None
None
SCL  A 700 ( 4.0A)
None
 0.92A 5dzkd-1ebvA:
undetectable
5dzkk-1ebvA:
undetectable
5dzky-1ebvA:
undetectable		 5dzkd-1ebvA:
17.11
5dzkk-1ebvA:
16.57
5dzky-1ebvA:
3.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 8 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
GLY A 526
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
None
SCL  A 700 ( 4.0A)
 0.63A 5f1aA-1ebvA:
58.7		 5f1aA-1ebvA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 8 VAL A 349
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 ( 4.6A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.35A 5f1aA-1ebvA:
58.7		 5f1aA-1ebvA:
63.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		6 / 7 VAL A 349
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 ( 4.6A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.26A 5f1aB-1ebvA:
31.9		 5f1aB-1ebvA:
63.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 11 VAL A 349
PHE A 518
SER A 353
GLN A 192
GLY A 193
 SCL  A 700 ( 4.6A)
None
None
None
None
 1.30A 5g6sB-1ebvA:
0.8
5g6sC-1ebvA:
0.0		 5g6sB-1ebvA:
18.78
5g6sC-1ebvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 10 SER A 353
GLN A 192
GLY A 193
VAL A 349
PHE A 518
 None
None
None
SCL  A 700 ( 4.6A)
None
 1.27A 5g6sD-1ebvA:
1.5
5g6sF-1ebvA:
0.9		 5g6sD-1ebvA:
18.78
5g6sF-1ebvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 10 SER A 353
GLN A 192
GLY A 193
VAL A 349
PHE A 518
 None
None
None
SCL  A 700 ( 4.6A)
None
 1.29A 5g6sA-1ebvA:
1.5
5g6sG-1ebvA:
0.8		 5g6sA-1ebvA:
18.78
5g6sG-1ebvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_H_RAUH400_1
(IMINE REDUCTASE)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 10 SER A 353
GLN A 192
GLY A 193
VAL A 349
PHE A 518
 None
None
None
SCL  A 700 ( 4.6A)
None
 1.30A 5g6sE-1ebvA:
0.9
5g6sH-1ebvA:
1.5		 5g6sE-1ebvA:
18.78
5g6sH-1ebvA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.46A 5ikqA-1ebvA:
33.9		 5ikqA-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 VAL A 116
SER A 353
MET A 522
 None
 0.38A 5ikqA-1ebvA:
33.9		 5ikqA-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.48A 5ikqB-1ebvA:
33.8		 5ikqB-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.49A 5ikrA-1ebvA:
58.6		 5ikrA-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 VAL A 116
LEU A 384
MET A 522
 None
 0.42A 5ikrA-1ebvA:
58.6		 5ikrA-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.42A 5ikrB-1ebvA:
58.5		 5ikrB-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		3 / 3 SER A 353
LEU A 384
MET A 522
 None
 0.35A 5ikrB-1ebvA:
58.5		 5ikrB-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 384
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.45A 5iktA-1ebvA:
35.0		 5iktA-1ebvA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
SER A 353
LEU A 384
TRP A 387
MET A 522
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.44A 5iktB-1ebvA:
58.8		 5iktB-1ebvA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 ILE A 233
HIS A 232
TYR A 234
ALA A 332
ILE A 343
 None
 1.42A 5iwuA-1ebvA:
undetectable		 5iwuA-1ebvA:
18.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.56A 5jvzA-1ebvA:
58.5		 5jvzA-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.58A 5jvzB-1ebvA:
58.3		 5jvzB-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.32A 5jw1A-1ebvA:
57.4		 5jw1A-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 6 VAL A 116
LEU A 352
SER A 353
ILE A 517
 None
SCL  A 700 ( 4.8A)
None
None
 0.28A 5jw1A-1ebvA:
57.4		 5jw1A-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		8 / 12 ARG A 120
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 (-3.9A)
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.84A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 HIS A  90
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.36A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 6 VAL A 116
VAL A 349
SER A 353
ILE A 517
 None
SCL  A 700 ( 4.6A)
None
None
 0.25A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 6 VAL A 349
SER A 353
ILE A 517
PHE A 518
 SCL  A 700 ( 4.6A)
None
None
None
 0.78A 5jw1B-1ebvA:
57.4		 5jw1B-1ebvA:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.30A 5kirA-1ebvA:
58.4		 5kirA-1ebvA:
63.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		9 / 12 HIS A  90
GLN A 192
VAL A 349
SER A 353
TYR A 355
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
None
SCL  A 700 ( 4.6A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.34A 5kirB-1ebvA:
58.7		 5kirB-1ebvA:
63.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 5 GLY A 225
ARG A 376
ASP A 229
GLN A 330
 None
 1.36A 5ubbA-1ebvA:
undetectable		 5ubbA-1ebvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 5 GLY A 227
ARG A 376
ASP A 229
GLN A 241
 None
 1.42A 5ubbA-1ebvA:
undetectable		 5ubbA-1ebvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 5 GLY A 227
ARG A 376
ASP A 229
GLN A 330
 None
 1.39A 5ubbA-1ebvA:
undetectable		 5ubbA-1ebvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		5 / 12 PHE A 292
ALA A 223
GLY A 231
GLY A 235
LEU A 294
 None
 1.04A 5ul4A-1ebvA:
undetectable		 5ul4A-1ebvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1ebv PROSTAGLANDIN H2
SYNTHASE
(Ovis
aries) 		4 / 7 VAL A 568
LEU A 294
PHE A 292
PHE A 426
 None
 1.07A 6aycA-1ebvA:
0.0		 6aycA-1ebvA:
11.30