SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ece'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 6 TYR A 240
GLY A 284
GLY A 281
SER A 320
 BGC  A 402 ( 4.7A)
None
None
None
 0.98A 1eswA-1eceA:
2.6		 1eswA-1eceA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 4 VAL A 278
TRP A 316
TRP A 267
 None
 0.99A 1gmkC-1eceA:
undetectable
1gmkD-1eceA:
undetectable		 1gmkC-1eceA:
4.04
1gmkD-1eceA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 3 TRP A 316
VAL A 278
TRP A 279
 None
 1.29A 1gmkC-1eceA:
undetectable
1gmkD-1eceA:
undetectable		 1gmkC-1eceA:
4.04
1gmkD-1eceA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 5 ILE A 198
LEU A 196
VAL A 154
ALA A 102
 None
 0.91A 1mz9C-1eceA:
undetectable		 1mz9C-1eceA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 6 ALA A 125
TYR A 128
ILE A 176
PRO A 166
 None
 1.14A 1oniB-1eceA:
1.1
1oniC-1eceA:
0.1		 1oniB-1eceA:
16.67
1oniC-1eceA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 7 ARG A  22
ILE A  23
LEU A 197
GLY A 156
 None
 0.88A 1rtsB-1eceA:
0.0		 1rtsB-1eceA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 3 ARG A 147
ASN A  35
THR A  74
 None
 0.85A 2q63A-1eceA:
0.0		 2q63A-1eceA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		6 / 12 ASN A 161
GLU A 162
HIS A 238
TYR A 240
GLU A 282
TRP A 319
 BGC  A 403 (-3.5A)
BGC  A 402 ( 2.5A)
None
BGC  A 402 ( 4.7A)
BGC  A 403 (-2.8A)
BGC  A 403 ( 4.2A)
 0.73A 2v3dA-1eceA:
6.6		 2v3dA-1eceA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 11 ASN A 161
GLU A 162
TYR A 240
GLU A 282
TRP A 319
 BGC  A 403 (-3.5A)
BGC  A 402 ( 2.5A)
BGC  A 402 ( 4.7A)
BGC  A 403 (-2.8A)
BGC  A 403 ( 4.2A)
 0.83A 2v3dB-1eceA:
11.5		 2v3dB-1eceA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 3 SER A 353
THR A  60
PHE A 283
 None
 0.65A 2x91A-1eceA:
0.0		 2x91A-1eceA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 12 ASN A  59
ALA A 311
GLY A   3
VAL A 234
ILE A  23
 None
 1.07A 3c6gA-1eceA:
0.0		 3c6gA-1eceA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 9 ILE A  23
GLY A  25
ILE A  26
PRO A  64
ILE A 111
 None
 1.14A 3ekqB-1eceA:
undetectable		 3ekqB-1eceA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 6 ARG A 110
ASP A  51
TYR A 103
PRO A 357
 None
 1.38A 3jqaA-1eceA:
2.5		 3jqaA-1eceA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 6 ARG A 110
ASP A  51
TYR A 103
PRO A 357
 None
 1.35A 3jqaD-1eceA:
2.4		 3jqaD-1eceA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 7 TYR A 235
VAL A 203
TRP A 178
GLY A 219
 None
 0.99A 3kmoB-1eceA:
undetectable		 3kmoB-1eceA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 5 GLY A 202
GLU A 201
GLY A 215
PRO A 163
 None
 0.88A 3onnA-1eceA:
undetectable		 3onnA-1eceA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 10 SER A 191
ASN A 187
ILE A 138
ALA A 135
GLU A 134
 None
 1.16A 3u6tA-1eceA:
undetectable		 3u6tA-1eceA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 12 ALA A 143
GLN A 142
PHE A 157
VAL A 101
LEU A  94
 None
 1.16A 3uvvB-1eceA:
undetectable		 3uvvB-1eceA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 3 ASN A  27
TRP A 319
ASP A 158
 None
BGC  A 403 ( 4.2A)
None
 1.24A 4a7tA-1eceA:
0.0
4a7tF-1eceA:
0.0		 4a7tA-1eceA:
17.78
4a7tF-1eceA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 8 GLY A 202
LEU A 280
VAL A 278
TYR A 235
 None
 0.91A 4fgzA-1eceA:
undetectable		 4fgzA-1eceA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 6 ILE A 111
THR A  60
VAL A  96
ASP A  45
 None
 1.04A 4iaqA-1eceA:
undetectable		 4iaqA-1eceA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 3 HIS A  39
TRP A 319
SER A  78
 None
BGC  A 403 ( 4.2A)
None
 1.10A 4lrhD-1eceA:
0.0		 4lrhD-1eceA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 11 ALA A 143
GLN A 142
PHE A 157
VAL A 101
LEU A  94
 None
 1.18A 4nqaA-1eceA:
undetectable		 4nqaA-1eceA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 7 HIS A 238
TRP A 212
TRP A 213
THR A 328
 None
None
BGC  A 401 ( 3.8A)
BGC  A 403 ( 4.5A)
 1.41A 4tzuB-1eceA:
0.0
4tzuC-1eceA:
0.0		 4tzuB-1eceA:
12.57
4tzuC-1eceA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 7 THR A 328
HIS A 238
TRP A 212
TRP A 213
 BGC  A 403 ( 4.5A)
None
None
BGC  A 401 ( 3.8A)
 1.27A 4tzuB-1eceA:
0.0
4tzuC-1eceA:
0.0		 4tzuB-1eceA:
12.57
4tzuC-1eceA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 11 LEU A  41
LEU A 113
LEU A  63
ILE A 111
LEU A 144
 None
 1.04A 4zowA-1eceA:
undetectable		 4zowA-1eceA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 5 ILE A  61
LEU A 332
HIS A  39
VAL A  38
 None
 1.19A 5jmnB-1eceA:
0.1		 5jmnB-1eceA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 5 ASP A 324
GLY A 330
PRO A 323
TRP A 321
 None
 1.42A 5nn8A-1eceA:
2.3		 5nn8A-1eceA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 9 TYR A 346
ILE A  26
ILE A  61
LEU A  63
 None
 0.77A 5vkqB-1eceA:
0.0
5vkqC-1eceA:
0.0		 5vkqB-1eceA:
12.41
5vkqC-1eceA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 8 HIS A 238
TRP A 212
TRP A 213
THR A 328
 None
None
BGC  A 401 ( 3.8A)
BGC  A 403 ( 4.5A)
 1.33A 5yj1G-1eceA:
0.0
5yj1Y-1eceA:
0.0		 5yj1G-1eceA:
18.28
5yj1Y-1eceA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 8 THR A 328
HIS A 238
TRP A 212
TRP A 213
 BGC  A 403 ( 4.5A)
None
None
BGC  A 401 ( 3.8A)
 1.28A 5yj1k-1eceA:
0.0
5yj1t-1eceA:
0.0		 5yj1k-1eceA:
18.28
5yj1t-1eceA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 10 TYR A 240
HIS A 238
HIS A 116
GLN A 123
ASP A 114
 BGC  A 402 ( 4.7A)
None
BGC  A 403 ( 4.2A)
BGC  A 403 (-3.4A)
None
 1.13A 5zovA-1eceA:
0.0		 5zovA-1eceA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		5 / 12 TYR A 240
HIS A 238
HIS A 116
GLN A 123
ASP A 114
 BGC  A 402 ( 4.7A)
None
BGC  A 403 ( 4.2A)
BGC  A 403 (-3.4A)
None
 1.08A 5zovB-1eceA:
0.0		 5zovB-1eceA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 3 GLU A 183
ASP A 177
PRO A 174
 None
 0.73A 6berA-1eceA:
undetectable		 6berA-1eceA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		3 / 3 LEU A 109
ASP A  15
ILE A  13
 None
 0.42A 6dh0B-1eceA:
undetectable		 6dh0B-1eceA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ece ENDOCELLULASE E1
(Acidothermus
cellulolyticus) 		4 / 6 ASP A 344
GLN A  52
VAL A 339
ALA A  24
 None
 1.06A 6djzB-1eceA:
0.0		 6djzB-1eceA:
20.00