SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ecm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 6 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.92A 1mt1A-1ecmA:
undetectable
1mt1F-1ecmA:
undetectable		 1mt1A-1ecmA:
18.52
1mt1F-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 6 ARG A  29
LEU A  79
ASP A  83
LEU A  86
 None
 0.92A 1mt1B-1ecmA:
undetectable
1mt1C-1ecmA:
undetectable		 1mt1B-1ecmA:
19.51
1mt1C-1ecmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 5 ARG A  29
LEU A  79
ASP A  83
LEU A  86
 None
 0.94A 1n13B-1ecmA:
undetectable
1n13C-1ecmA:
undetectable		 1n13B-1ecmA:
19.51
1n13C-1ecmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 7 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.97A 1n13I-1ecmA:
undetectable
1n13L-1ecmA:
undetectable		 1n13I-1ecmA:
18.52
1n13L-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 7 ARG A  29
LEU A  79
ASP A  83
LEU A  86
 None
 0.95A 2qqcB-1ecmA:
undetectable
2qqcC-1ecmA:
undetectable		 2qqcB-1ecmA:
19.51
2qqcC-1ecmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 7 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.94A 2qqcA-1ecmA:
undetectable
2qqcF-1ecmA:
undetectable		 2qqcA-1ecmA:
18.52
2qqcF-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 7 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.92A 2qqcG-1ecmA:
undetectable
2qqcJ-1ecmA:
undetectable		 2qqcG-1ecmA:
18.52
2qqcJ-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 7 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.94A 2qqcI-1ecmA:
undetectable
2qqcL-1ecmA:
undetectable		 2qqcI-1ecmA:
18.52
2qqcL-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		4 / 7 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.97A 2qqdA-1ecmA:
undetectable
2qqdE-1ecmA:
undetectable		 2qqdA-1ecmA:
18.18
2qqdE-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE
(Escherichia
coli) 		3 / 3 LEU A  25
ILE A  80
TYR A  72
 None
 0.65A 5uunB-1ecmA:
undetectable		 5uunB-1ecmA:
16.49