SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 7 ILE A  34
PHE A 100
ALA A  30
ILE A  23
 HEM  A 137 (-4.2A)
HEM  A 137 (-3.5A)
None
None
 0.92A 1oniB-1ecoA:
undetectable
1oniC-1ecoA:
undetectable		 1oniB-1ecoA:
23.03
1oniC-1ecoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 7 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.09A 1v55C-1ecoA:
undetectable
1v55J-1ecoA:
0.0		 1v55C-1ecoA:
20.00
1v55J-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 7 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.08A 2eimC-1ecoA:
undetectable
2eimJ-1ecoA:
0.0		 2eimC-1ecoA:
20.00
2eimJ-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 7 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.05A 2einC-1ecoA:
undetectable
2einJ-1ecoA:
0.0		 2einC-1ecoA:
20.00
2einJ-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.09A 2einP-1ecoA:
undetectable
2einW-1ecoA:
0.0		 2einP-1ecoA:
20.00
2einW-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		5 / 12 ALA A  30
ALA A  26
PHE A  55
GLN A  40
ILE A  49
 None
 1.13A 2jjpA-1ecoA:
undetectable		 2jjpA-1ecoA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.14A 3ablP-1ecoA:
undetectable
3ablW-1ecoA:
0.0		 3ablP-1ecoA:
20.00
3ablW-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 7 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.00A 3ag2P-1ecoA:
undetectable
3ag2W-1ecoA:
0.0		 3ag2P-1ecoA:
20.00
3ag2W-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		3 / 3 PHE A 128
ASP A 126
ARG A 101
 None
 0.88A 4eahF-1ecoA:
undetectable		 4eahF-1ecoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		3 / 3 PHE A 128
ASP A 126
ARG A 101
 None
 0.88A 4eahG-1ecoA:
undetectable		 4eahG-1ecoA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 5 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.94A 5dzkb-1ecoA:
undetectable
5dzkp-1ecoA:
undetectable		 5dzkb-1ecoA:
22.12
5dzkp-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.94A 5dzkB-1ecoA:
undetectable
5dzkP-1ecoA:
undetectable		 5dzkB-1ecoA:
22.12
5dzkP-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 5 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.95A 5dzkc-1ecoA:
undetectable
5dzkq-1ecoA:
undetectable		 5dzkc-1ecoA:
22.12
5dzkq-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 7 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.96A 5dzkD-1ecoA:
undetectable
5dzkR-1ecoA:
undetectable		 5dzkD-1ecoA:
22.12
5dzkR-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 8 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.96A 5dzkd-1ecoA:
undetectable
5dzkr-1ecoA:
undetectable		 5dzkd-1ecoA:
22.12
5dzkr-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 5 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.94A 5dzkf-1ecoA:
undetectable
5dzkt-1ecoA:
undetectable		 5dzkf-1ecoA:
22.12
5dzkt-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 8 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.95A 5dzkF-1ecoA:
undetectable
5dzkT-1ecoA:
undetectable		 5dzkF-1ecoA:
22.12
5dzkT-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 SER A  86
ALA A  85
HIS A  87
MET A 136
 HEM  A 137 ( 3.7A)
None
HEM  A 137 (-3.3A)
None
 0.95A 5dzkg-1ecoA:
undetectable
5dzku-1ecoA:
undetectable		 5dzkg-1ecoA:
22.12
5dzku-1ecoA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 8 PHE A  65
GLY A  64
THR A  82
PHE A 129
 HEM  A 137 (-4.9A)
None
None
None
 0.98A 5flcB-1ecoA:
undetectable		 5flcB-1ecoA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 8 PHE A  65
GLY A  64
THR A  82
PHE A 129
 HEM  A 137 (-4.9A)
None
None
None
 0.97A 5flcF-1ecoA:
undetectable		 5flcF-1ecoA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.08A 5z84P-1ecoA:
undetectable
5z84W-1ecoA:
0.0		 5z84P-1ecoA:
20.00
5z84W-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.02A 5z85P-1ecoA:
undetectable
5z85W-1ecoA:
0.0		 5z85P-1ecoA:
20.00
5z85W-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.06A 5z86C-1ecoA:
undetectable
5z86J-1ecoA:
0.0		 5z86C-1ecoA:
20.00
5z86J-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.06A 5z86P-1ecoA:
undetectable
5z86W-1ecoA:
0.0		 5z86P-1ecoA:
20.00
5z86W-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.09A 5zcpC-1ecoA:
undetectable
5zcpJ-1ecoA:
0.0		 5zcpC-1ecoA:
20.00
5zcpJ-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.08A 5zcpP-1ecoA:
undetectable
5zcpW-1ecoA:
0.0		 5zcpP-1ecoA:
20.00
5zcpW-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1eco ERYTHROCRUORIN
(CARBONMONOXY)
(Chironomus
thummi) 		4 / 6 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 0.92A 6nmpC-1ecoA:
undetectable
6nmpJ-1ecoA:
0.0		 6nmpC-1ecoA:
20.00
6nmpJ-1ecoA:
15.44