SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ecw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_A_SVRA205_1 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	1ecw	GAG POLYPROTEIN (Simian immunodeficiency virus)	4 / 7	ASN A 53 LYS A 54 TYR A 79 PHE A 44	None	1.17A	4yv5A-1ecwA: undetectable	4yv5A-1ecwA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AJQ_A_DB8A800_2 (SERINE/THREONINE-PRO TEIN KINASE 10)	1ecw	GAG POLYPROTEIN (Simian immunodeficiency virus)	4 / 4	VAL A 82 ILE A 88 ASN A 53 VAL A 7	None	1.23A	5ajqA-1ecwA: undetectable	5ajqA-1ecwA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDH_D_DAHD60_1 (PUTATIVE CYTOCHROME C)	1ecw	GAG POLYPROTEIN (Simian immunodeficiency virus)	4 / 5	HIS A 33 ASN A 80 VAL A 84 LEU A 16	None	1.48A	5xdhD-1ecwA: 0.3	5xdhD-1ecwA: 16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CK2_C_IPHC101_0 (INSULIN A CHAIN INSULIN B CHAIN)	1ecw	GAG POLYPROTEIN (Simian immunodeficiency virus)	4 / 4	ILE A 88 LEU A 51 HIS A 33 ALA A 37	None	1.04A	6ck2C-1ecwA: undetectable 6ck2D-1ecwA: undetectable	6ck2C-1ecwA: 13.33 6ck2D-1ecwA: 13.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4YV5_A_SVRA205_1","BASIC PHOSPHOLIPASE A2 HOMOLOG 2","1ecw","GAG POLYPROTEIN","Simian immunodeficiency virus",4,"ASN A  53;LYS A  54;TYR A  79;PHE A  44","None","1.17A","4yv5A-1ecwA:undetectable","4yv5A-1ecwA:21.32"],["5AJQ_A_DB8A800_2","SERINE\/THREONINE-PROTEIN KINASE 10","1ecw","GAG POLYPROTEIN","Simian immunodeficiency virus",4,"VAL A  82;ILE A  88;ASN A  53;VAL A   7","None","1.23A","5ajqA-1ecwA:undetectable","5ajqA-1ecwA:21.72"],["5XDH_D_DAHD60_1","PUTATIVE CYTOCHROME C","1ecw","GAG POLYPROTEIN","Simian immunodeficiency virus",4,"HIS A  33;ASN A  80;VAL A  84;LEU A  16","None","1.48A","5xdhD-1ecwA:0.3","5xdhD-1ecwA:16.18"],["6CK2_C_IPHC101_0","INSULIN A CHAIN;INSULIN B CHAIN","1ecw","GAG POLYPROTEIN","Simian immunodeficiency virus",4,"ILE A  88;LEU A  51;HIS A  33;ALA A  37","None","1.04A","6ck2C-1ecwA:undetectable;6ck2D-1ecwA:undetectable","6ck2C-1ecwA:13.33;6ck2D-1ecwA:13.22"]]