SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ecx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 10 LEU A 132
VAL A 136
ILE A 164
GLU A 193
VAL A 174
 None
 1.16A 1cqpA-1ecxA:
2.1
1cqpB-1ecxA:
2.1		 1cqpA-1ecxA:
17.96
1cqpB-1ecxA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ALA A 281
LEU A 366
PHE A 365
LEU A 311
LEU A 307
 None
 1.16A 1dtlA-1ecxA:
undetectable		 1dtlA-1ecxA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A 244
ALA A 247
ALA A 248
ILE A  64
ALA A 201
 None
 0.95A 2aclG-1ecxA:
undetectable		 2aclG-1ecxA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ASP A 160
THR A  95
PRO A  96
 None
 0.60A 2pynB-1ecxA:
undetectable		 2pynB-1ecxA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ASP A 160
THR A  95
PRO A  96
 None
 0.66A 2q64B-1ecxA:
undetectable		 2q64B-1ecxA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ASP A 160
THR A  95
PRO A  96
 None
 0.59A 2qakB-1ecxA:
undetectable		 2qakB-1ecxA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 LEU A  57
ARG A  50
VAL A 210
GLY A 211
 None
 1.08A 2qd5B-1ecxA:
undetectable		 2qd5B-1ecxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ARG A 350
ILE A 155
ALA A 148
VAL A 334
LEU A 335
 CYS  A 502 (-2.4A)
None
None
None
None
 1.26A 3s79A-1ecxA:
undetectable		 3s79A-1ecxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 4 LEU A 224
ILE A  92
TYR A 196
TYR A 108
 None
 0.90A 3vt7A-1ecxA:
0.0		 3vt7A-1ecxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 5 ASN A  43
ARG A  50
MET A  46
HIS A  45
 None
 0.86A 4g5jA-1ecxA:
0.0		 4g5jA-1ecxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 ILE A 185
LEU A 192
ALA A 147
ALA A 148
ILE A 289
 None
 0.80A 4h1nA-1ecxA:
undetectable		 4h1nA-1ecxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ARG A 249
GLU A 252
ALA A 261
GLU A 256
ARG A  16
 None
 1.47A 4i00A-1ecxA:
undetectable		 4i00A-1ecxA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 10 VAL A 152
VAL A 340
GLY A 347
ALA A 348
SER A 298
 None
 1.11A 4ph9A-1ecxA:
0.0		 4ph9A-1ecxA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 10 VAL A 152
VAL A 340
GLY A 347
ALA A 348
SER A 298
 None
 1.10A 4ph9B-1ecxA:
0.0		 4ph9B-1ecxA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A 373
LEU A 307
ILE A 369
ILE A 351
VAL A 297
 None
 0.99A 4y0sA-1ecxA:
undetectable		 4y0sA-1ecxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 8 ALA A   9
HIS A  99
ASN A 150
LYS A 203
ARG A 350
 CYS  A 502 ( 4.2A)
PLP  A 500 ( 3.6A)
CYS  A 502 ( 3.3A)
PLP  A 500 (-2.4A)
CYS  A 502 (-2.4A)
 0.53A 5db5A-1ecxA:
42.7
5db5B-1ecxA:
42.4		 5db5A-1ecxA:
27.38
5db5B-1ecxA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ARG A 350
ILE A 155
ALA A 148
VAL A 334
LEU A 335
 CYS  A 502 (-2.4A)
None
None
None
None
 1.26A 5jkvA-1ecxA:
undetectable		 5jkvA-1ecxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LYS A 203
GLN A 156
ASN A 149
 PLP  A 500 (-2.4A)
None
None
 0.94A 5l2tA-1ecxA:
0.0		 5l2tA-1ecxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A  17
ASP A  14
ALA A 247
GLN A 180
GLY A 183
 None
None
None
PLP  A 500 (-4.0A)
None
 1.00A 5m54E-1ecxA:
undetectable		 5m54E-1ecxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A  17
ASP A  14
ALA A 247
GLN A 180
GLY A 183
 None
None
None
PLP  A 500 (-4.0A)
None
 1.16A 5m5cB-1ecxA:
undetectable		 5m5cB-1ecxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 LEU A 276
PHE A 365
LEU A 307
ILE A 372
 None
 0.88A 5mzjA-1ecxA:
0.0		 5mzjA-1ecxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 10 PHE A 299
GLY A 304
ILE A 349
ILE A 369
ILE A 372
 None
 1.06A 6ebpD-1ecxA:
undetectable		 6ebpD-1ecxA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 PHE A 299
GLY A 304
ILE A 349
ILE A 369
ILE A 372
 None
 1.06A 6ebzA-1ecxA:
undetectable		 6ebzA-1ecxA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 PHE A 299
GLY A 304
ILE A 349
ILE A 369
ILE A 372
 None
 1.05A 6ebzB-1ecxA:
undetectable		 6ebzB-1ecxA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 PHE A 299
GLY A 304
ILE A 349
ILE A 369
ILE A 372
 None
 1.06A 6ebzD-1ecxA:
undetectable		 6ebzD-1ecxA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 PHE A 299
GLY A 304
ILE A 349
ILE A 369
ILE A 372
 None
 1.06A 6gp2A-1ecxA:
undetectable		 6gp2A-1ecxA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1ecx AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 11 PHE A 299
GLY A 304
ILE A 349
ILE A 369
ILE A 372
 None
 0.97A 6gp2B-1ecxA:
undetectable		 6gp2B-1ecxA:
12.92