SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ed3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		3 / 3 ASP A 198
THR A 200
GLU A 229
 None
 0.80A 1pj7A-1ed3A:
undetectable		 1pj7A-1ed3A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		3 / 3 ALA A 187
VAL A 189
TRP A 217
 None
 0.85A 1w5uC-1ed3A:
undetectable
1w5uD-1ed3A:
undetectable		 1w5uC-1ed3A:
4.78
1w5uD-1ed3A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		4 / 6 TYR A   7
TYR A  27
TYR A   9
GLN A  96
 None
 1.47A 2pgzD-1ed3A:
0.0
2pgzE-1ed3A:
2.1		 2pgzD-1ed3A:
19.16
2pgzE-1ed3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		5 / 12 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.22A 2yzqA-1ed3A:
undetectable		 2yzqA-1ed3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.01A 2zm8A-1ed3A:
0.0		 2zm8A-1ed3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.06A 2zmaA-1ed3A:
0.0		 2zmaA-1ed3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		4 / 7 TYR A  74
GLU A  97
TYR A 152
TRP A 133
 None
 1.26A 3cotA-1ed3A:
undetectable		 3cotA-1ed3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		3 / 3 ALA A 187
VAL A 189
TRP A 217
 None
 0.80A 3l8lC-1ed3A:
undetectable
3l8lD-1ed3A:
undetectable		 3l8lC-1ed3A:
4.78
3l8lD-1ed3A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		5 / 9 TYR A 159
TYR A  99
ALA A  67
TYR A   7
TYR A   9
 None
 1.48A 3rodB-1ed3A:
0.0		 3rodB-1ed3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		5 / 10 TYR A 159
TYR A  99
ALA A  67
TYR A   7
TYR A   9
 None
 1.45A 3rodC-1ed3A:
undetectable		 3rodC-1ed3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		4 / 6 ASP A 116
ALA A 139
ASP A 137
THR A 143
 None
 0.93A 3rozA-1ed3A:
undetectable		 3rozA-1ed3A:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.54A 3uprA-1ed3A:
33.9		 3uprA-1ed3A:
74.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.52A 3uprC-1ed3A:
34.2		 3uprC-1ed3A:
74.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		6 / 10 TYR A   9
TYR A  74
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.58A 3vriA-1ed3A:
34.2
3vriC-1ed3A:
undetectable		 3vriA-1ed3A:
74.55
3vriC-1ed3A:
4.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		7 / 12 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.51A 3vrjA-1ed3A:
34.2
3vrjC-1ed3A:
undetectable		 3vrjA-1ed3A:
74.55
3vrjC-1ed3A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		3 / 3 TRP A 217
GLN A 226
THR A 216
 None
 0.65A 4m2xA-1ed3A:
0.4		 4m2xA-1ed3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		4 / 6 ASP A  77
TYR A  99
TYR A 152
LEU A 156
 None
 1.35A 5bmvB-1ed3A:
undetectable		 5bmvB-1ed3A:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.55A 5u98A-1ed3A:
34.3		 5u98A-1ed3A:
74.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA
(Rattus
norvegicus) 		7 / 10 TYR A   9
TYR A  74
ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.56A 5u98D-1ed3A:
34.1		 5u98D-1ed3A:
74.55