SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1edg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		5 / 12 GLY A 269
LEU A 264
ASN A 260
VAL A 311
GLU A 350
 None
 1.40A 1a27A-1edgA:
undetectable		 1a27A-1edgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.74A 1jnoA-1edgA:
undetectable		 1jnoA-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.74A 1jnoB-1edgA:
undetectable		 1jnoB-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.91A 1jo3A-1edgA:
undetectable		 1jo3A-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.91A 1jo3B-1edgA:
undetectable		 1jo3B-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.90A 1jo4A-1edgA:
undetectable		 1jo4A-1edgA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.90A 1jo4B-1edgA:
undetectable		 1jo4B-1edgA:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.78A 1magA-1edgA:
undetectable		 1magA-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.78A 1magB-1edgA:
undetectable		 1magB-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.76A 1ng8A-1edgA:
undetectable		 1ng8A-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.76A 1ng8B-1edgA:
undetectable		 1ng8B-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.85A 1nruA-1edgA:
undetectable		 1nruA-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 ALA A  41
VAL A  82
TRP A  99
 None
 0.84A 1nruB-1edgA:
undetectable		 1nruB-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		4 / 6 PRO A 171
HIS A 123
ASP A 126
TYR A 131
 None
 1.07A 2lh8A-1edgA:
0.0		 2lh8A-1edgA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		5 / 12 ARG A  79
GLU A 166
TYR A 256
ASN A 169
HIS A 122
 None
 1.50A 3bjmB-1edgA:
undetectable		 3bjmB-1edgA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		4 / 8 ASP A 124
TYR A 144
VAL A  82
LEU A 119
 None
 1.11A 3jq7C-1edgA:
2.3		 3jq7C-1edgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		5 / 11 LEU A 119
PHE A 165
ILE A 152
ASP A 124
PHE A 203
 None
 1.32A 3ko0O-1edgA:
undetectable
3ko0P-1edgA:
undetectable
3ko0Q-1edgA:
undetectable
3ko0R-1edgA:
undetectable		 3ko0O-1edgA:
13.94
3ko0P-1edgA:
13.94
3ko0Q-1edgA:
13.94
3ko0R-1edgA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		4 / 8 VAL A 253
TYR A 256
CYH A 257
ILE A 292
 None
 1.01A 4afgD-1edgA:
0.0
4afgE-1edgA:
0.0		 4afgD-1edgA:
20.51
4afgE-1edgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		5 / 12 PRO A  18
GLY A  22
ASN A  24
ILE A 250
ARG A 299
 None
 1.23A 4kosA-1edgA:
0.0		 4kosA-1edgA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 PRO A  81
ASN A 169
HIS A 254
 None
 1.01A 4ma3H-1edgA:
0.0
4ma3L-1edgA:
undetectable		 4ma3H-1edgA:
18.42
4ma3L-1edgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		4 / 6 ILE A 304
ARG A  79
GLY A  32
HIS A 254
 None
 1.07A 4oltA-1edgA:
0.0		 4oltA-1edgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		4 / 6 ILE A 304
ARG A  79
GLY A  32
HIS A 254
 None
 1.05A 4oltB-1edgA:
0.0		 4oltB-1edgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		4 / 5 ILE A  80
PRO A  81
TYR A 144
VAL A 148
 None
 1.24A 4s0vA-1edgA:
undetectable		 4s0vA-1edgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		4 / 8 ILE A 335
TYR A 293
ILE A 304
PHE A 376
 None
 0.87A 4v04A-1edgA:
undetectable		 4v04A-1edgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 PHE A 165
ILE A 152
ASP A 124
 None
 0.76A 5cswA-1edgA:
undetectable		 5cswA-1edgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		5 / 9 VAL A 107
VAL A 103
ILE A 152
PHE A 165
LEU A 163
 None
 1.36A 5e4dA-1edgA:
0.0		 5e4dA-1edgA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 GLU A 170
TRP A 180
HIS A 123
 None
 0.76A 5xipA-1edgA:
0.0		 5xipA-1edgA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1edg ENDOGLUCANASE A
([Clostridium]
cellulolyticum) 		3 / 3 MET A 138
ASP A 202
ARG A 237
 None
 1.21A 5z6jA-1edgA:
0.0		 5z6jA-1edgA:
17.08