SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1edz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.20A 1zzrA-1edzA:
0.0
1zzrB-1edzA:
0.0		 1zzrA-1edzA:
22.37
1zzrB-1edzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.18A 1zzrA-1edzA:
0.0
1zzrB-1edzA:
0.0		 1zzrA-1edzA:
22.37
1zzrB-1edzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.18A 1zzuA-1edzA:
0.4
1zzuB-1edzA:
0.0		 1zzuA-1edzA:
22.37
1zzuB-1edzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.18A 1zzuA-1edzA:
0.4
1zzuB-1edzA:
0.0		 1zzuA-1edzA:
22.37
1zzuB-1edzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 201
ALA A 202
VAL A 248
ILE A 164
VAL A 182
 None
 0.85A 2bpxB-1edzA:
undetectable		 2bpxB-1edzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 201
ALA A 202
VAL A 248
ILE A 164
VAL A 182
 None
 0.96A 2pynB-1edzA:
undetectable		 2pynB-1edzA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 201
ALA A 202
VAL A 248
ILE A 164
VAL A 182
 None
 0.93A 2q63B-1edzA:
undetectable		 2q63B-1edzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 201
ALA A 202
VAL A 248
ILE A 164
VAL A 182
 None
 0.93A 2qakB-1edzA:
undetectable		 2qakB-1edzA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 195
ALA A 194
ALA A 198
GLN A 213
 None
 0.77A 3a2qA-1edzA:
0.0		 3a2qA-1edzA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.19A 3dqrA-1edzA:
0.0
3dqrB-1edzA:
0.0		 3dqrA-1edzA:
22.27
3dqrB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.14A 3dqrA-1edzA:
0.0
3dqrB-1edzA:
0.0		 3dqrA-1edzA:
22.27
3dqrB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.19A 3jx2A-1edzA:
0.0
3jx2B-1edzA:
0.0		 3jx2A-1edzA:
22.27
3jx2B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.19A 3jx2A-1edzA:
0.0
3jx2B-1edzA:
0.0		 3jx2A-1edzA:
22.27
3jx2B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.20A 3jx3A-1edzA:
0.4
3jx3B-1edzA:
0.0		 3jx3A-1edzA:
22.27
3jx3B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.20A 3jx3A-1edzA:
0.4
3jx3B-1edzA:
0.0		 3jx3A-1edzA:
22.27
3jx3B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.19A 3jx4A-1edzA:
0.0
3jx4B-1edzA:
0.7		 3jx4A-1edzA:
22.27
3jx4B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.20A 3jx5A-1edzA:
0.0
3jx5B-1edzA:
0.7		 3jx5A-1edzA:
22.27
3jx5B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.17A 3jx5A-1edzA:
0.0
3jx5B-1edzA:
0.7		 3jx5A-1edzA:
22.27
3jx5B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.16A 3jx6A-1edzA:
0.5
3jx6B-1edzA:
0.4		 3jx6A-1edzA:
22.27
3jx6B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.17A 3jx6A-1edzA:
0.5
3jx6B-1edzA:
0.4		 3jx6A-1edzA:
22.27
3jx6B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.18A 3n61A-1edzA:
0.5
3n61B-1edzA:
0.7		 3n61A-1edzA:
22.27
3n61B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.18A 3n61A-1edzA:
0.5
3n61B-1edzA:
0.7		 3n61A-1edzA:
22.27
3n61B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.18A 3nljA-1edzA:
0.7
3nljB-1edzA:
0.0		 3nljA-1edzA:
22.27
3nljB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.14A 3nljA-1edzA:
0.7
3nljB-1edzA:
0.0		 3nljA-1edzA:
22.27
3nljB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.21A 3nlpA-1edzA:
0.0
3nlpB-1edzA:
0.0		 3nlpA-1edzA:
22.27
3nlpB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.19A 3nlpA-1edzA:
0.0
3nlpB-1edzA:
0.0		 3nlpA-1edzA:
22.27
3nlpB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.20A 3nlqA-1edzA:
0.0
3nlqB-1edzA:
0.0		 3nlqA-1edzA:
22.27
3nlqB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.21A 3nlqA-1edzA:
0.0
3nlqB-1edzA:
0.0		 3nlqA-1edzA:
22.27
3nlqB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.22A 3nlrA-1edzA:
0.0
3nlrB-1edzA:
0.0		 3nlrA-1edzA:
22.27
3nlrB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.17A 3nlrA-1edzA:
0.0
3nlrB-1edzA:
0.0		 3nlrA-1edzA:
22.27
3nlrB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 201
ALA A 202
VAL A 248
ILE A 164
VAL A 182
 None
 0.91A 3oxcA-1edzA:
undetectable		 3oxcA-1edzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 201
ALA A 202
VAL A 248
ILE A 164
VAL A 182
 None
 0.96A 3tkgD-1edzA:
undetectable		 3tkgD-1edzA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.19A 4cx3A-1edzA:
0.6
4cx3B-1edzA:
0.0		 4cx3A-1edzA:
22.27
4cx3B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.20A 4cx3A-1edzA:
0.6
4cx3B-1edzA:
0.0		 4cx3A-1edzA:
22.27
4cx3B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.19A 4cx4A-1edzA:
0.4
4cx4B-1edzA:
0.0		 4cx4A-1edzA:
22.27
4cx4B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.20A 4cx4A-1edzA:
0.4
4cx4B-1edzA:
0.0		 4cx4A-1edzA:
22.27
4cx4B-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 268
ALA A 269
ASP A 247
THR A 262
 None
 0.88A 4eyrB-1edzA:
0.0		 4eyrB-1edzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 246
PHE A 260
PHE A 280
ILE A 183
VAL A 248
 None
 1.37A 4yfbC-1edzA:
0.0		 4yfbC-1edzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 246
PHE A 260
PHE A 280
ILE A 183
VAL A 248
 None
 1.38A 4yfbF-1edzA:
undetectable		 4yfbF-1edzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 246
PHE A 260
PHE A 280
ILE A 183
VAL A 248
 None
 1.35A 4yfbI-1edzA:
0.0		 4yfbI-1edzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 246
PHE A 260
PHE A 280
ILE A 183
VAL A 248
 None
 1.36A 4yfbL-1edzA:
0.0		 4yfbL-1edzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.20A 5addA-1edzA:
0.0
5addB-1edzA:
0.0		 5addA-1edzA:
22.27
5addB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.17A 5adeA-1edzA:
0.0
5adeB-1edzA:
0.0		 5adeA-1edzA:
22.27
5adeB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 120
VAL A 114
PHE A  42
GLU A 121
 None
 1.18A 5g0pA-1edzA:
0.0
5g0pB-1edzA:
0.0		 5g0pA-1edzA:
22.27
5g0pB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  42
GLU A 121
VAL A 120
VAL A 114
 None
 1.16A 5g0pA-1edzA:
0.0
5g0pB-1edzA:
0.0		 5g0pA-1edzA:
22.27
5g0pB-1edzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 100
THR A 151
SER A 186
ILE A 188
VAL A 189
 None
 0.89A 6debB-1edzA:
30.3		 6debB-1edzA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1edz 5,10-METHYLENETETRAH
YDROFOLATE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 100
THR A 151
SER A 186
VAL A 189
THR A 299
 None
 0.82A 6debB-1edzA:
30.3		 6debB-1edzA:
16.17