SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ee0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 5 HIS A 308
SER A 196
LEU A 110
GLY A 221
 None
 1.06A 1a4lB-1ee0A:
undetectable		 1a4lB-1ee0A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 VAL A 387
LEU A 375
VAL A 229
ILE A  24
ILE A  27
 None
 0.95A 1epbB-1ee0A:
0.0		 1epbB-1ee0A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 ASP A 352
VAL A 194
ILE A 193
ILE A 241
ILE A  24
 None
 1.06A 1fapA-1ee0A:
undetectable		 1fapA-1ee0A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 ASP A 352
VAL A 194
ILE A 193
ILE A 241
ILE A  24
 None
 1.08A 1fklA-1ee0A:
undetectable		 1fklA-1ee0A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 LEU A 348
GLY A 172
GLY A 173
LEU A 375
ILE A 244
 None
 0.86A 1mx1D-1ee0A:
undetectable		 1mx1D-1ee0A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 9 ALA A 179
GLY A 230
ALA A  22
LEU A 389
LEU A 176
 None
 1.17A 1nr6A-1ee0A:
undetectable		 1nr6A-1ee0A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		3 / 3 VAL A 215
ALA A 216
HIS A 204
 CAA  A 600 (-4.9A)
None
None
 0.68A 1q23G-1ee0A:
0.1		 1q23G-1ee0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		3 / 3 VAL A 215
ALA A 216
HIS A 204
 CAA  A 600 (-4.9A)
None
None
 0.72A 1q23J-1ee0A:
0.0		 1q23J-1ee0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 ILE A 314
HIS A 308
PHE A 220
GLY A 221
LEU A 348
 None
None
CAA  A 600 (-4.6A)
None
None
 0.95A 2nyrB-1ee0A:
undetectable		 2nyrB-1ee0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 VAL A 354
ILE A  24
LEU A 389
ILE A 350
THR A 366
 None
 1.12A 2w3vA-1ee0A:
undetectable		 2w3vA-1ee0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 8 ILE A 228
ALA A 115
LEU A 149
ILE A 129
 None
 0.71A 2w9sE-1ee0A:
undetectable		 2w9sE-1ee0A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 6 THR A 174
VAL A 175
GLU A 197
CYH A 195
 None
 1.16A 3b6rB-1ee0A:
undetectable		 3b6rB-1ee0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 GLY A 168
ILE A 201
LEU A 164
VAL A 140
GLN A 100
 CAA  A 600 (-3.3A)
None
None
None
None
 1.30A 3fzgA-1ee0A:
undetectable		 3fzgA-1ee0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 10 ALA A 171
LEU A 348
VAL A 347
ILE A 244
LEU A 389
 None
 1.05A 3jw5B-1ee0A:
undetectable		 3jw5B-1ee0A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 LEU A 389
ALA A 331
ILE A  24
CYH A 346
GLY A 172
 None
 1.24A 4hfpB-1ee0A:
undetectable		 4hfpB-1ee0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 8 LYS A 112
GLY A 154
LEU A 155
LEU A 192
 None
 0.83A 4po0A-1ee0A:
undetectable		 4po0A-1ee0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		3 / 3 PHE A 220
THR A 383
LEU A 261
 CAA  A 600 (-4.6A)
None
CAA  A 600 (-4.5A)
 0.62A 4qztA-1ee0A:
0.2		 4qztA-1ee0A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 8 THR A  23
GLU A 121
LEU A 235
LEU A 124
GLY A 230
 None
 1.26A 4r3aA-1ee0A:
undetectable		 4r3aA-1ee0A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 7 VAL A 347
ILE A 350
LEU A 324
LEU A 329
 None
 0.92A 4xo7A-1ee0A:
undetectable		 4xo7A-1ee0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 LEU A 322
LYS A 328
SER A 293
LEU A 292
SER A 302
 None
 1.36A 4zbrA-1ee0A:
undetectable		 4zbrA-1ee0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 LEU A 322
LYS A 328
SER A 293
LEU A 292
SER A 302
 None
 1.30A 5dbyA-1ee0A:
undetectable		 5dbyA-1ee0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 8 ILE A 241
ALA A  22
THR A  23
VAL A 229
 None
 0.88A 5ecnD-1ee0A:
0.0		 5ecnD-1ee0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 8 TYR A  44
TYR A  41
GLY A 205
LEU A  82
 None
 0.70A 5esfA-1ee0A:
undetectable		 5esfA-1ee0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 11 ASP A 352
VAL A 194
ILE A 193
ILE A 241
ILE A  24
 None
 1.20A 5hw8D-1ee0A:
undetectable		 5hw8D-1ee0A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 8 ASP A 352
VAL A 194
ILE A 193
ILE A 241
 None
 0.93A 5hw8H-1ee0A:
undetectable		 5hw8H-1ee0A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 9 LEU A 375
ARG A 355
ILE A  24
GLU A 243
VAL A 245
 None
 1.01A 5igzA-1ee0A:
0.0		 5igzA-1ee0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 7 HIS A 308
ILE A 350
VAL A 307
ARG A 333
 None
 1.15A 5kkzC-1ee0A:
0.0
5kkzE-1ee0A:
undetectable		 5kkzC-1ee0A:
18.25
5kkzE-1ee0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 7 HIS A 308
ILE A 350
VAL A 307
ARG A 333
 None
 1.10A 5kkzK-1ee0A:
undetectable
5kkzQ-1ee0A:
0.0		 5kkzK-1ee0A:
21.68
5kkzQ-1ee0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		3 / 3 ARG A 274
PHE A 378
LEU A 219
 CAA  A 600 (-3.1A)
None
CAA  A 600 ( 4.8A)
 0.81A 5veuA-1ee0A:
0.0		 5veuA-1ee0A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		5 / 12 ILE A 251
THR A 250
GLN A 249
THR A 174
VAL A 175
 None
 1.07A 6bzoC-1ee0A:
0.0		 6bzoC-1ee0A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1ee0 2-PYRONE SYNTHASE
(Gerbera
hybrid
cultivar) 		4 / 8 ILE A 251
THR A 250
THR A 174
ARG A 177
 None
 0.95A 6c06C-1ee0A:
0.0		 6c06C-1ee0A:
undetectable